| DBH | Dopamine-Beta(¥â)-Hydroxylase |
|---|---|
| AF | abnormal frequency; acid-fast; adult female; afebrile; aflatoxin; albumin-free; albumose-free; aldeh... |
| AFB | acid-fast bacillus; aflatoxin B; air fluidized bed; aortofemoral bypass |
| AFG | aflatoxin G; amniotic fluid glucose |
| AFM | aflatoxin M; after fatty meal; American Federation of Musicians |
| AFB1 | 3H]-aflatoxin B1 |
|---|---|
| AF | Aflatoxin |
| AFB | Aflatoxin B1 |
| AFM(1) | Aflatoxin M(1 |
| AFQ1 | Aflatoxin Q1 |
| aflatoxin B1 hydroxylase | <enzyme> Hydroxylases may be replaced by mixed function oxidases as appropriate Registry number: EC 1.14.- Synonym: aflatoxin b1 4-hydroxylase (26 Jun 1999) |
|---|
| aflatoxin | <chemical, microbiology, oncology> A fungal toxin which is a powerful liver carcinogen, found particularly in undeveloped and developing countries. A group of closely related toxic metabolites that are designated mycotoxins. They are produced by aspergillus flavus and a. Parasiticus. Members of the group include aflatoxin b1, aflatoxin b2, aflatoxin g1, aflatoxin g2, aflatoxin m1, and aflatoxin m2. Pharmacological action: carcinogens, mutagens, teratogens. (27 Jun 1999) |
|---|---|
| aflatoxin b1 | <chemical> A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cotton seed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin b1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin m1 and q1. Pharmacological action: carcinogens, mutagens, teratogens. Chemical name: Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)- (27 Jun 1999) |
| aflatoxin B1 aldehyde reductase | <enzyme> Catalyses the conversion of the dialdehydic form of aflatoxin b1-dihydrodiol to the dialcohol form Registry number: EC 1.1.1.- Synonym: aflatoxin b1-aldehyde reductase, afb1-ar (26 Jun 1999) |
| aflatoxin B1 reductase | <enzyme> Reduces the cyclopentenone ring of aflatoxin b1 to aflatoxicol; requires NADPH as cofactor Registry number: EC 1.1.1.- (26 Jun 1999) |
| aflatoxin G2a reductase | <enzyme> Has broad substrate specificity in cell-free extracts from aspergillus parasiticus; versicolorin a hemiacetal is reduced to versicolorin c; 17-hydroxy-16,17-dihydrosterigmatocystin is reduced to a 14,17-hydrated derivative; aflatoxin g2a is converted to a 13,16-hydrated derivative of afg2 Registry number: EC 1.1.1.- (26 Jun 1999) |
| aflatoxin m1 | <chemical> Highly toxic 4-hydroxylated metabolite of aflatoxin b1 found in the milk of cows fed toxic meal. It has mutagenic, carcinogenic, and teratogenic activity. It is formed by the enzymatic hydroxylation of aflatoxin b1 by aflatoxin b1 4-hydroxylase, a cytochrome p-450-dependent enzyme. Pharmacological action: carcinogens, mutagens, teratogens. Chemical name: Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)- (27 Jun 1999) |
| abscisic acid 8'-hydroxylase | <enzyme> Catalyses conversion of abscisic acid to 8'-hydroxyabscisic acid, which rearranges to phaseic acid Registry number: EC 1.14.99.- Synonym: aba 8'-hydroxylase (26 Jun 1999) |
| aklavinone 11-hydroxylase | <enzyme> A flavin-type bacterial hydroxylase from streptomyces peucetius; 489 amino acid residues, mw 52.3 kD; genbank u09844 Registry number: EC 1.14.14.- Synonym: dnrf protein, dnrf gene product (26 Jun 1999) |
| aniline hydroxylase | <enzyme> A drug-metabolizing, cytochrome p-450 enzyme which catalyses the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. Registry number: EC 1.14.14.- (12 Dec 1998) |
| arachidonic acid 18-hydroxylase | <enzyme> Converts arachidonic acid to 18-hydroxy-5,8,11,14-eicosatetraenoic acid in the presence of NADPH; cytochrome p450 enzyme Registry number: EC 1.14.13.- Synonym: arachidonic acid 18(r)-hydroxylase, arachidonic acid omega 3-hydroxylase (26 Jun 1999) |
| arylamine N-hydroxylase | <enzyme> Cytochrome p-448 dependent Registry number: EC 1.14.13.- Synonym: 2-aminofluorene n-hydroxylase (26 Jun 1999) |
| benzopyrene hydroxylase | <enzyme> A drug-metabolizing, cytochrome p-448 (p-450) enzyme which catalyses the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. Registry number: EC 1.14.14.- (12 Dec 1998) |
| beta-carotene hydroxylase | <enzyme> O2-dependent NADPH-dependent monooxygenase from erwinia herbicola; forms zeaxanthin; amino acid sequence has been determined; genbank m87280 Registry number: EC 1.14.13.- Synonym: beta-carotene monooxygenase, crtz gene product (26 Jun 1999) |
| biphenyl-4-hydroxylase | <enzyme> Mixed function oxidase Registry number: EC 1.14.14.- (26 Jun 1999) |
| bufuralol 1'-hydroxylase | <enzyme> Liver microsomal enzyme utilizing NADPH and cytochrome p-450; competetive inhibition by debrisoquine Registry number: EC 1.14.99.- Synonym: bufuralol 1'-monooxygenase (26 Jun 1999) |
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