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AF abnormal frequency; acid-fast; adult female; afebrile; aflatoxin; albumin-free; albumose-free; aldeh...
AFB acid-fast bacillus; aflatoxin B; air fluidized bed; aortofemoral bypass
AFG aflatoxin G; amniotic fluid glucose
AFM aflatoxin M; after fatty meal; American Federation of Musicians
AFQ aflatoxin Q
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AFB1 3H]-aflatoxin B1
AF Aflatoxin
AFB Aflatoxin B1
AFM(1) Aflatoxin M(1
AFQ1 Aflatoxin Q1
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aflatoxin <chemical, microbiology, oncology> A fungal toxin which is a powerful liver carcinogen, found particularly in undeveloped and developing countries.
A group of closely related toxic metabolites that are designated mycotoxins. They are produced by aspergillus flavus and a. Parasiticus. Members of the group include aflatoxin b1, aflatoxin b2, aflatoxin g1, aflatoxin g2, aflatoxin m1, and aflatoxin m2.
Pharmacological action: carcinogens, mutagens, teratogens.
(27 Jun 1999)
aflatoxin b1 <chemical> A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals.
It is found as a contaminant in peanuts, cotton seed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin b1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin m1 and q1.
Pharmacological action: carcinogens, mutagens, teratogens.
Chemical name: Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-
(27 Jun 1999)
aflatoxin B1 aldehyde reductase <enzyme> Catalyses the conversion of the dialdehydic form of aflatoxin b1-dihydrodiol to the dialcohol form
Registry number: EC 1.1.1.-
Synonym: aflatoxin b1-aldehyde reductase, afb1-ar
(26 Jun 1999)
aflatoxin B1 hydroxylase <enzyme> Hydroxylases may be replaced by mixed function oxidases as appropriate
Registry number: EC 1.14.-
Synonym: aflatoxin b1 4-hydroxylase
(26 Jun 1999)
aflatoxin B1 reductase <enzyme> Reduces the cyclopentenone ring of aflatoxin b1 to aflatoxicol; requires NADPH as cofactor
Registry number: EC 1.1.1.-
(26 Jun 1999)
aflatoxin G2a reductase <enzyme> Has broad substrate specificity in cell-free extracts from aspergillus parasiticus; versicolorin a hemiacetal is reduced to versicolorin c; 17-hydroxy-16,17-dihydrosterigmatocystin is reduced to a 14,17-hydrated derivative; aflatoxin g2a is converted to a 13,16-hydrated derivative of afg2
Registry number: EC 1.1.1.-
(26 Jun 1999)
aflatoxin m1 <chemical> Highly toxic 4-hydroxylated metabolite of aflatoxin b1 found in the milk of cows fed toxic meal.
It has mutagenic, carcinogenic, and teratogenic activity. It is formed by the enzymatic hydroxylation of aflatoxin b1 by aflatoxin b1 4-hydroxylase, a cytochrome p-450-dependent enzyme.
Pharmacological action: carcinogens, mutagens, teratogens.
Chemical name: Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-
(27 Jun 1999)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 3 ÆäÀÌÁö: 1
  • Aflatoxin B1 - »õâ A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
    Synonyms : Aflatoxin B, Aflatoxin B1 Dihydrochloride, (6aR-cis)-Isomer, Aflatoxin B1, (6aR-cis)-Isomer, 14C-Labeled, Aflatoxin B1, (6aR-cis)-Isomer, 2H-Labeled, Aflatoxin B1, (6aR-cis)-Isomer, 3H-Labeled, Aflatoxin B1, cis(+, -)-Isomer, HSDB-3453, NSC-529592
  • Aflatoxin M1 - »õâ A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
    Synonyms : 4-Hydroxyaflatoxin B1, Aflatoxin M, Aflatoxin M1, cis(+-)-Isomer, 4 Hydroxyaflatoxin B1
  • Aflatoxins - »õâ Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.
    Synonyms : Aflatoxin
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aflatoxin a potent carcinogen from the fungus Aspergillus; can be produced and stored for use as a bioweapon
Ãâó: wordnet.princeton.edu/perl/webwn
aflatoxin (af
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aflatoxin A harmful substance made by certain types of mold (
Ãâó: www.stjude.org/glossary
aflatoxin Any of several toxins produced by fungi that can cause cancer
Ãâó: www.deh.gov.au/settlements/industry/finance/glossa...
aflatoxin a carcinogenic compound produced by the mould Aspergillus flavus that contaminates some food products such as peanuts.
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