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| GCL | globoid cell leukodystrophy |
|---|---|
| GLD | globoid leukodystrophy; glutamate dehydrogenase |
| MLD | manual lymph drainage; median lethal dose; metachromatic leukodystrophy; minimal lesion disease; min... |
| OLD | obstructive lung disease; orthochromatic leukodystrophy |
| PML | peripheral motor latency; polymorphonuclear leukocyte; posterior mitral leaflet; progressive multifo... |
| GLD | Globoid cell leukodystrophy |
|---|---|
| MLD | Metachromatic Leukodystrophy |
| AA | Adrenal androgen |
| AHC | Adrenal hypoplasia congenita |
| AI | Adrenal insufficiency |
| adrenal leukodystrophy | Sudanophilic leukodystrophy with bronzing of skin and adrenal atrophy. A metabolic disorder of young males, characterised by widespread myelin degeneration and associated adrenal insufficiency. The myelin degeneration is massive in various portions of the brain and sometimes the spinal cord, with the accumulation of degradation products of myelin in macrophages: sudanophilic demyelination; atrophy is present in the adrenal glands and testes, and markedly increased amounts of very long-chain fatty acid are present in both the brain and adrenal glands. Symptoms include bronzing of the skin, dysarthria, cortical blindness, bilateral hemiplegia, pseudobulbar paralysis, and progressive dementia. Probably sex-linked recessive inheritance. (05 Mar 2000) |
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| globoid cell leukodystrophy | <radiology> Dysmyelinating disease, autosomal recessive, usually presents by 1 yr, specific enzyme deficiency identified, rapid spontaneous nystagmus, poikilothermia Synonym: Krabbe leukodystrophy (12 Dec 1998) |
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| metachromatic leukodystrophy | <radiology> Dysmyelinating disease, autosomal recessive, aryl sulfatase A -- absent from urine and serum, most present by 2 yrs, die at 3-4 yrs, may arise at any age, CT: decreased density of white matter, primarily in centrum semiovale, with or without focal gall bladder defects (!) (12 Dec 1998) |
| leukodystrophy | <radiology> Type of dysmyelinating disease, hereditary, peripheral nervous system unaffected in some disorders Specific diseases: adrenoleukodystrophy, metachromatic leukodystrophy, spongy degeneration (Canavan), globoid cell (Krabbe) leukodystrophy, Alexander disease, Pelizaeus-Merzbacher disease, Cockayne syndrome (12 Dec 1998) |
| leukodystrophy, globoid cell | An inherited metabolic disorder of the nervous system, particularly the white matter. It is characterised histologically by a paucity of myelin and oligodendroglia, severe astrocytic gliosis, and massive infiltration with unique multinucleated globoid cells which are enriched in galactosylceramide. The primary genetic defect is a deficiency of galactosylceramidase. (12 Dec 1998) |
| leukodystrophy, metachromatic | A sphingolipidosis where there is defective desulfation of galactosyl-3-sulfate ceramide due to a defective enzyme cerebroside sulfatase (arylsulfatase a). The result is an accumulation of sulfatide in neural and non-neural tissues which manifests as mental deterioration and severe disturbances of the central nervous system. (12 Dec 1998) |
| leukodystrophy with diffuse Rosenthal fibre formation | A metabolic disorder whose onset can be in infancy, adolescence, or adulthood; characterised pathologically by widespread cerebral demyelination with astrocyte and primitive oligodendroglial cell proliferation; refractile Rosenthal fibres result from the degeneration of these proliferating cells; aetiology unknown, but possibly due to a metabolic defect of astrocytes; sex-linked recessive disorder. (05 Mar 2000) |
| accessory adrenal | An island of cortical tissue separate from the adrenal gland, usually found in the retroperitoneal tissues, kidney, or genital organs. Synonym: adrenal rest. (05 Mar 2000) |
| acute adrenal crisis | <endocrinology> An abrupt life-threatening state which is caused by insufficient production of cortisol by the adrenal gland. A typical finding in Addison's disease. Individuals who have been taking corticosteroids (glucocorticoids) for a prolonged period of time (weeks to months) are at risk for acute adrenal crisis if the medication is stopped abruptly. For this reason, corticosteroid medication are withdrawn slowly on a diminishing dosing schedule. Symptoms include low blood pressure (shock), weakness, headache, vomiting, fever chills, tachycardia and sweating. Treatment includes blood pressure support and intravenous hydrocortisone. (27 Sep 1997) |
| adenoma, adrenal cortical | A benign neoplasm of adrenal cortical cells resembling normal adrenal cells histologically but possessing functional autonomy. In general it does not exceed 5 cm in its largest dimension, although benign tumours exceeding 20 cm have been reported. Adrenal cortical adenomas produce hypercortisolism and hyperaldosteronism, but seldom produce adrenogenital syndromes. For the most part the prognosis after surgery is reasonably favourable. (12 Dec 1998) |
| adrenal | <anatomy> Suprarenal. Origin: Pref. Ad- + renal. Source: Websters Dictionary (01 Mar 1998) |
| adrenal adenoma | <radiology> Benign adrenal tumour, hyperfunctioning adenoma can cause, primary hyperaldosteronism, Cushing syndrome, nonfunctional adenoma seen in 2-8% of population, differentiate from metastasis, MRI: metastasis bright on T2, biopsy, follow see: adrenal mass (12 Dec 1998) |
| adrenal androgen | Any androgenic hormone of adrenocortical origin; e.g., dehydroepiandrosterone (and its sulfate), androstenedione, 11b-hydroxyandrostenedione. (05 Mar 2000) |
| adrenal androgen-stimulating hormone | A putative pituitary hormone that may be responsible for increased secretion of adrenal androgens at the time of puberty. (05 Mar 2000) |
| adrenal angiography | <radiology> Adrenal arteriography, 3 arteries: superior - inferior phrenic a., middle - aorta, inferior - renal a., difficult to inject all 3; arteriography usually not attempted adrenal venography, venous sampling, may define anatomy, may rupture capsule and ablate function (12 Dec 1998) |
| adrenal apoplexy | Haemorrhage into the adrenal glands or thrombosis of the adrenal veins, followed by acute adrenal insufficiency, occurring in the Waterhouse-Friderichsen syndrome. (05 Mar 2000) |
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