| TPT | Topotecan |
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| topotecan | <drug, oncology> This alkaloid chemotherapy drug is a derivative of the drug camptothecin, which was originally isolated from a Chinese tree, Camptotheca acuminata but has also been found in the nothapodytes tree (Nothapodytes foetida).Topotecan is a DNA topoisomerase I inhibitor and is used to treat advanced ovarian cancer. (09 Oct 1997) |
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Synonyms : 9-Dimethylaminomethyl-10-hydroxycamptothecin, Hycamtamine, Hycamtin, NSC-609699, Nogitecan Hydrochloride, SK&F-104864-A, SKF-104864-A, Topotecan Hydrochloride, Topotecan Monohydrochloride, (S)-Isomer, 9 Dimethylaminomethyl 10 hydroxycamptothecin, NSC 609699
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a cytotoxic inhibitor of DNA topoismerase (type I topoisomerase), which prevents the rejoining of DNA strands following breakage by DNA topoisomerase, leading to double-strand DNA breakage and cell death, used as a secondary agent in the treatment of metastatic ovarian carcinoma and refractory small cell lung carcinoma; administered by intravenous infusion.
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