| 영문 | thyroid hormone | 한글 | 갑상샘호르몬 |
|---|---|---|---|
| 설명 | 광의의 갑상선호르몬은 티록신(thyroxine(T4)), 삼요드티로닌(triiodothyronine (T3)), 티로칼시토닌(thyrocalcitonin)의 3가지중 하나를 말하나 대개의 경우 협의의 뜻으로 사용되며 이 경우 티록신과 삼요드티로닌을 지칭한다. 갑상선 호르몬은 거의 모든 몸세포에서의 바탕질대사에 관여하여 에너지생성을 증가시키고 성장 발육을 촉진한다. 이것은 뇌하수체에서 분비되는 갑상샘 자극호르몬에 의해 합성 및 분비가 촉진된다. 섭취하여 체내에 들어온 요오드가 능동운반에 의해 갑상샘세포내로 들어가 세포내에 있는 단백질인 갑상샘 글로블린과 결합하여 갑상샘호르몬으로 합성된다. 요오드가 3분자 결합한 것을 T3, 4분자 결합한 것을 T4라 부름. 분비되는 갑상선 호르몬중 90%이상이 T4이다. 혈중으로 분비된 갑상샘호르몬은 혈중 단백질과 결합하는데 대부분은 티론신결합글로블린과 결합하며 일부는 알부민과 결합한다. 전반적인 대사율을 촉진시키며 어린이에서는 성장을 촉진시킨다. 특히 어린이에서 몰단백질 합성을 촉진하며 뇌의 발달에 중요한 기능을 함으로써, 선천성 갑상샘저하증(cretinism)을 조기 발견하여 치료하지 못하면 정신지체가 유발된다. 갑상샘과다증의 증상은 체내 대사가 항진되어 식욕이 증가하나 체중이 감소하고 심장박동수가 증가하고 더위를 참지 못하며, 갑상샘기능저하증의 증상은 위와 반대로 식욕이 감소하고 체중이 증가하며 심장박동수가 감소하고 추위를 참지 못하며 피부에 단백질이 축적되어 점액부종이 유발된다. |
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| 영문 | receptor | 한글 | 수용체 |
|---|---|---|---|
| 설명 | 세포질내 또는 세포표면에 존재하는 분자구조로서 특이물질과 선택적으로 결합하며 결합에 의해 특이한 생리적 작용을 나타낸다. 펩티드호르몬, 신경전달물질, 항원, 보체, 면역글로불린에 대한 세포표면 수용체와 스테로이드에 대한 세포질내 수용체가 있다. |
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| 영문 | thyroid gland | 한글 | 갑상샘 |
|---|---|---|---|
| 설명 | 사람의 몸에서 가장 큰 내분비샘으로 목의 앞쪽, 아래쪽에 위치하고 있으며 2엽으로 구성되어 있다. 각 엽은 기관의 양쪽에 있으며 좁은 잘룩에 의해 앞에서 연결되어 있다. 갑상샘호르몬인 티록신(thyroxine)을 분비하고 저장하며, 필요에 따라 방출한다. 또한 갑상샘은 티로칼시토닌(thyrocalcitonin)도 분비한다. 병적인 상태에서 크기가 대개 증가하고, 일부에서는 도리어 위축되며, 통증을 나타내기도 한다. |
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| 영문 | thyroid carcinoma | 한글 | 갑상샘암종 |
|---|---|---|---|
| 설명 | 갑상샘에 생긴 상피세포로 이루어진 악성종양물. 병리조직학적인 형태에 따라 유두상, 소포상, 역형암종 및 수질암종, 림프종 등으로 나눌 수 있다. 다양한 원인이 있으나, 일부에서는 방사선폭로에 의해 발생한다. 치료는 수술, 방사성 옥소, T4 억제요법 등이 사용된다. |
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| 영문 | adrenocorticotropic hormone | 한글 | 부신겉질자극호르몬 |
|---|---|---|---|
| 설명 | 뇌하수체 전엽에서 분비되어 부신겉질을 자극하는 단백성 호르몬. 하수체전염에서 만들어져 분비되는 호르몬이다. 부신겉질자극 작용이 있으며 부신겉질질세포의 경우에 스테로이드호르몬 생합성의 조절단계인 콜레스테롤로부터의 프레그네롤론생성을 촉진한다. 결정글루코코르티코이드에 의해 반대의 되먹임조정을 받는다. 글루코코르티코이드의 하수체전엽에 대한 직접작용과 시상하부의 부신겉질자극호르몬 방출호르몬을 매체로 한 간접작용이 있다. 여러 종류의 정신적 육체적 스트레스에 의해 분비가 자극된다. |
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| HTS | head traumatic syndrome; HeLa tumor suppression; human thyroid-stimulating hormone, human thyroid st... |
|---|---|
| THR | targeted heart rate; threonine; thyroid hormone receptor; total hip replacement; transhepatic resist... |
| THRA | thyroid hormone receptor alpha |
| TSHR | thyroid-stimulating hormone receptor |
| TSH-RH | thyroid-stimulating hormone-releasing hormone |
| T3R | 1-thyroid hormone receptor |
|---|---|
| TRbeta | Thyroid hormone receptor beta |
| TR alpha | thyroid hormone receptor alpha |
| TSHr | thyroid simulating hormone receptor |
| TSH | E--thyroid-stimulating hormone |
| thyroid receptor antibody | A test that measures the amount of an antibody (thyroid stimulating antibody) which is directed against a receptor for TSH on the thyroid gland. This antibody acts like TSH and stimulates the thyroid to produce excessive amounts of thyroid hormone. The presence of this antibody generally indicates Grave's disease (hyperthyroidism). (27 Sep 1997) |
|---|---|
| hormone receptor assay | A diagnostic test to determine whether a breast cancer's growth is influenced by hormones or if it can be treated with hormones. (09 Oct 1997) |
| receptors, thyroid hormone | Proteins, usually found in the nucleus, that specifically bind thyroid hormones and regulate DNA transcription. These proteins, termed c-erba, are activated by hormones and cause differentiation of erythroid progenitor cells which irreversibly lose proliferative potential. Thus c-erba proteins act as growth suppressors. The c-erba proteins are encoded by at least two genes, c-erba alpha and c-erba beta. Each of these has two isoforms. Mutations in the ligand-binding domain of the beta form causes thyroid hormone resistance syndrome. (12 Dec 1998) |
| hormone, thyroid | Chemical substance made by the thyroid gland which is located in the front of the neck. The thyroid gland uses iodine to make thyroid hormones. The two most important thyroid hormones are thyroxine (t4) and triiodothyronine (t3). (12 Dec 1998) |
| hormone, thyroid stimulating | A hormone produced by the pituitary gland (at the base of the brain) that promotes the growth of the thyroid gland (in the neck) and stimulates it to produce its thyroid hormones. Normally, the rate of thyroid hormone production is controlled by the pituitary. When there are insufficient thyroid hormones in the body for normal functioning of the cells, the pituitary releases tsh. Tsh in turn stimulates the thyroid gland to produce more thyroid hormones. In contrast, when there is excessive amount of thyroid hormones, the pituitary gland stops producing tsh. The tsh level then falls and thyroid hormone production is reduced. This mechanism maintains a relatively constant level of thyroid hormones circulating in the blood. This phenomenon is analogous to a thermostat used for temperature regulation in a room: when the temperature rises, the thermostat shuts the heater off and the room temperature falls back to normal. High levels of thyroid hormones cause the tsh level to fall, resulting in no further stimulation of the thyroid gland. In hyperthyroidism, there are continuously elevated levels of the thyroid hormones. Tsh is also known as thyrotropin. (12 Dec 1998) |
| thyroid hormone | <endocrinology> Thyroxine and tri iodothyronine are hormones secreted by the thyroid gland in vertebrates. These iodinated aromatic amino acid compounds influence growth and metabolism and, in amphibia, metamorphosis. The hormone calcitonin which has hypocalcaemic effects is also of thyroid origin but is not usually classed with thyroxine and tri iodothyronine as a thyroid hormone. (18 Nov 1997) |
| thyroid hormone aminotransferase | <enzyme> Chemical name: 3,5-dinitrotyrosine aminotransferase Registry number: EC 2.6.1.26 Synonym: triiodothyrone aminotransferase, triiodothyronine aminotransferase (26 Jun 1999) |
| thyroid hormone resistance syndrome | <syndrome> An inherited syndrome of peripheral resistance to thyroid hormones, transmitted as an autosomal recessive trait, characterised by increased serum concentrations of thyroxine and triiodothyronine, increased thyroid hormone binding ratio, and normal to slightly increased thyroid-stimulating hormone and its response to thyrotropin-releasing hormone. The affected persons are euthyroid to slightly hypothyroid. The absence of hypermetabolism and the presence of possible hypothyroidism indicate the existence of partial resistance to the peripheral action of thyroid hormone. (12 Dec 1998) |
| thyroid releasing hormone | <endocrinology> Thyroid releasing hormone (TRH) is a byproduct of the hypothalamus and serves to stimulate the pituitary gland to produce thyroid stimulating hormone (TSH). TRH is produced by the hypothalamus when thyroid hormone (T3 and T4) blood levels are low. (27 Sep 1997) |
| thyroid stimulating hormone | <endocrinology> Polypeptide hormone (28 kD), secreted by the anterior pituitary gland, that activates cyclic AMP production in thyroid cells leading to production and release of the thyroid hormones (T4 and T3). T4 and T3 blood levels feedback on the pituitary gland and decrease thyroid stimulating hormone production when T3 and T4 levels are high. (27 Sep 1997) |
| thyroid-stimulating hormone | thyroid stimulating hormone |
| thyroid-stimulating hormone-releasing factor | <protein> See thyrotrophic releasing hormone. (18 Nov 1997) |
| thyroid-stimulating hormone stimulation test | TSH stimulating test, a test that measures the uptake of 131I in the thyroid gland before and after administration of thyroid-stimulating hormone; useful in distinguishing primary hyperthyroidism (increased TSH serum concentration) from secondary or tertiary hyperthyroidism (low TSH serum concentrations). (05 Mar 2000) |
| receptors, pituitary hormone-regulating hormone | Cell surface receptors that bind the hypothalamic hormones regulating pituitary cell differentiation, proliferation, and hormone synthesis and release, including the pituitary-releasing and release-inhibiting hormones. The pituitary hormone-regulating hormones are also released by cells other than hypothalamic neurons, and their receptors also occur on non-pituitary cells, especially brain neurons, where their role is less well understood. Receptors for dopamine, which is a prolactin release-inhibiting hormone as well as a common neurotransmitter, are not included here. (12 Dec 1998) |
| growth hormone inhibiting hormone | <protein> Gastrointestinal and hypothalmic peptide hormone (two forms: 14 and 28 residues), found in gastric mucosa, pancreatic islets, nerves of the gastrointestinal tract, in posterior pituitary and in the central nervous system. Inhibits gastric secretion and motility: in hypothalamus/pituitary inhibits somatotropin release. (18 Nov 1997) |
Synonyms : ERBA1 Gene Products, NR1A1 Gene Products, THRA Gene Products, Thyroid Hormone Receptor alpha-1, Thyroid Hormone Receptor alpha-2, c-erb A Protein, c-erb A Proteins, c-erbA Proteins, c-erbA alpha, c-erbA alpha Protein, c-erbA-1 Protein, Gene Products, ERBA1
Synonyms : ERBA2 Gene Products, NR1A2 Gene Products, THRB Gene Products, TR beta, Thyroid Hormone Receptor beta, Thyroid Hormone Receptor beta-1, Thyroid Hormone Receptor beta-2, c-erbA beta, Gene Products, ERBA2, Gene Products, NR1A2, Gene Products, THRB, c erbA beta
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|