| ¿µ¹® | deoxyribonucleic acid (DNA) | ÇÑ±Û | µ¥¿Á½Ã¸®º¸ÇÙ»ê |
|---|---|---|---|
| ¼³¸í | ÇÙ»êÀÇ ÀÏÁ¾À¸·Î DNA¶ó°íµµ ÇÑ´Ù. DeoxyribonucleotideÀÇ ÁßÇÕüÀ̸ç À¯ÀüÀÚÀÇ ÈÇÐÀû º»Ã¼ÀÌ´Ù. RNA¹ÙÀÌ·¯½º ÀÌ¿ÜÀÇ ¸ðµç »ý¹°Àº DNA¸¦ À¯ÀüÀÚ·Î Áö´Ï°í ÀÖ´Ù. µð¿Á½Ã¸®º¸´ºÅ¬·¹¿ÀƼµå(deoxyribonucleotide)´Â ¿°±â¿Í ´ç(2'-deoxy-D-ribose)°ú ÀλêÀ¸·Î ÀÌ·ç¾îÁø´Ù. ¿°±â´Â ¾Æµ¥´Ñ(adenine), ±¸¾Æ´Ñ(guanine), Ƽ¹Î(thymine)¹× ½ÃÅä½Å(cytosine)ÀÇ 4°¡ÁöÀ̸ç, À̰ÍÀº ´ç¿¡ ºÎÂøµÇ¾î ÀÖ´Ù. ÀÎ»ê ¿ª½Ã ´çÀÇ ÇÑ ºÎºÐ¿¡ ºÎÂøµÇ¾î ÀÖ´Ù. ÀÌ deoxyribonucleotideÀÇ ´çÀº ´Ù¸¥ deoxy- ribonucleotideÀÇ ´ç°ú ÀλêÀ» »çÀÌ¿¡ ³õ°í °áÇÕÀ» ÇÏ°Ô µÇ¾î ÇϳªÀÇ ±ä »ç½½À» Çü¼ºÇÏ°Ô µÈ´Ù. Áï ´ç°ú ÀλêÀÌ ÁÖÃàÀÌ µÇ¾î¼ deoxyribonucleotideÀÇ ±ä »ç½½À» ¸¸µç´Ù. ÀÌ deoxyribonucleotideÀÇ »ç½½ µÎ °³´Â °¢°¢ deoxyribonucleotide¿¡ ºÎÂøµÇ¾î ÀÖ´Â ¿°±âµéÀÌ °áÇÕÀ» ÇÏ¿© µÎ °³ÀÇ »ç½½ÀÌ °áÇյǾî ÀÖ´Â ÀÌÁß³ª¼± ±¸Á¶¸¦ ¸¸µé°Ô µÈ´Ù. 4°¡Áö ¿°±â ¾Æµ¥´ÑÀº Ƽ¹Î°ú °áÇÕÀ» Çϰí, ½ÃÅä½Å°ú °áÇÕÀ» ÇÏ°Ô µÈ´Ù. Áï ´ç°ú ÀλêÀº ±ä »ç½½À» ¸¸µå´Â ¿ªÇÒÀ» ÇÏ°í ±ä »ç½½¿¡ ºÎÂøµÈ ¿°±âµéÀÇ °áÇÕ¿¡ ÀÇÇØ¼ µÎ °³ÀÇ ±ä »ç½½Àº ¼·Î ºÙ¾î¼ ÀÌÁß³ª¼± ±¸Á¶¸¦ ¸¸µç´Ù. DNAÀÇ À¯ÀüÁ¤º¸´Â ¿°±â¿¡ ÀúÀåµÈ´Ù. 4°³ÀÇ ¿°±âÀÇ Á¶ÇÕ°ú ¹è¿ÀÌ À¯ÀüÁ¤º¸¸¦ º¸°üÇÏ´Â ÇϳªÀÇ ¾ÏÈ£ ¿ªÇÒÀ» ÇàÇÏ°Ô µÈ´Ù. |
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| ¿µ¹® | DNA | ÇÑ±Û | µð¿Á½Ã¸®º¸ÇÙ»ê, µð¿£¿¡ÀÌ |
|---|---|---|---|
| ¼³¸í | Deoxyribonucleic acidÀÇ ¾à¾î. µ¥¿Á½Ã¸®º¸½º¸¦ ±¸¼º¼ººÐÀ¸·Î ÇÏ´Â ÇÙ»ê. À¯ÀüÀÚÀÇ ÈÇÐÀû º»Å·μ ¿°»öü¿¡ Á¸ÀçÇÑ´Ù. µ¥¿Á½Ã¸®º¸½º¿¡ À¯±â¿°±â¿Í ÀλêÀÌ °áÇÕÇÑ ´ºÅ¬·¹¿ÀƼµå(±¸¼º´ÜÀ§)°¡ Æ÷½ºÆ÷µð¿¡½ºÅ׸£°áÇÕ¿¡ ÀÇÇØ ±ä»ç½½ ÁßÇÕü¸¦ Çü¼ºÇϸç, µÎ °³ÀÇ ±ä»ç½½ÀÌ ¼·Î ºñƲ·Á ²¿ÀÎ ³ª¼±±¸Á¶¸¦ ÃëÇÑ´Ù. µð¿Á½Ã¸®º¸´ºÅ¬·¹¿ÀƼµå(deoxyribonucleotide)´Â ¿°±â¿Í ´ç(2'-deoxy-D-riboe)°ú ÀλêÀ¸·Î ÀÌ·ç¾îÁø´Ù. ¿°±â´Â ¾Æµ¥´Ñ(adenine), ±¸¾Æ´Ñ(guanine), Ƽ¹Î(thymine) ¹× ½ÃÅä½Å(cytosine)ÀÇ ³×°¡ÁöÀ̸ç, À̰ÍÀº ´ç¿¡ ºÎÂøµÇ¾î ÀÖ´Ù. ÀÎ»ê ¿ª½Ã ´çÀÇ ÇÑ ºÎºÐ¿¡ ºÎÂøµÇ¾î ÀÖ´Ù. ÀÌ µð¿Á½Ã¸®º¸´ºÅ¬·¹¿ÀƼµåÀÇ ´çÀº ´Ù¸¥ µð¿Á½Ã¸®º¸´ºÅ¬·¹¿ÀƼµåÀÇ ´ç°ú ÀλêÀ» »çÀÌ¿¡ ³õ°í °áÇÕÇÏ°Ô µÇ¾î ÇϳªÀÇ ±ä »ç½½À» Çü¼ºÇÏ°Ô µÈ´Ù. |
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| AT/GC | adenine-thymine/guanine-cytosine [ratio] |
|---|---|
| TAG | target attaching globulin; technical advisory group; thymine, adenine, and guanine |
| Thy | thymine |
| AAG | 3-alkaladenine deoxyribonucleic acid glycosylase; allergic angiitis and granulomatosis; alpha-1-acid... |
| DGU | uracil deoxyribonucleic acid glycosylase |
| TDG | thymine DNA glycosylase |
|---|---|
| T-T | thymine-thymine |
| MPG | 3-methylpurine-DNA glycosylase |
| FPG | Formamidopyrimidine-DNA glycosylase |
| UDG | Uracil DNA N-glycosylase |
IGF-II : insulin like growth factor-IIÀÇ ¾àÀÚ. ¸¹Àº Àå±â¿Í Á¶Á÷¿¡ ÀÛ¿ëÇÏ¿© ´Ü¹é ÇÕ¼º°ú DNA, RNAÀÇ ÇÕ¼ºÀ» Áõ°¡½ÃÄÑ ¼¼Æ÷ÀÇ ¼ö¿Í ¾çÀ» Áõ°¡
| hydroxymethyluracil DNA glycosylase | <enzyme> Functions to eliminate hydroxymethyluracil from oxidatively damaged DNA Registry number: EC 3.2.2.- Synonym: hmu DNA glycosylase (26 Jun 1999) |
|---|---|
| DNA glycosylase | <enzyme, molecular biology> Class of enzymes involved in DNA repair. They recognise altered bases in DNA and catalyse their removal by cleaving the glycosidic bond between the base and the deoxyribose sugar. at least 20 such enzymes occur in cells. (18 Nov 1997) |
| 5-methylcytosine-DNA glycosylase | <enzyme> Binds equally well to methylated and non-methylated DNA; isolated from developing chicken embryos and mouse fibroblasts; mw 52.5 kD Registry number: EC 3.2.2.- (26 Jun 1999) |
| formamidopyridine-DNA glycosylase | <enzyme> Substrate is the ring-opened form of 7-methylguanine; has been sequenced; genbank af026691 Registry number: EC 3.2.2.23 Synonym: fap-DNA glycosylase, fapy-DNA glycosylase, formamidopyrimidine-DNA glycosylase, 8-oxoguanine DNA glycosylase, 8-hydroxyguanine DNA glycosylase, 8-hydroxyguanine endonuclease, 8-oh-gua endonuclease, fpg protein, E coli, fpg gene product, E coli, mutm protein, oh8 guanine excision repair enzyme, ogg1 gene product (26 Jun 1999) |
| hypoxanthine-aminopterin-thymine medium | A type of agar growth medium (a selective medium) which is used to select for cells that are able to make their nucleic acids out of hypoxanthine and/or thymine. All cells are prevented from making nucleotides by any other means (due to the presence of aminopterin or other drugs in the medium), so cells which are unable to use hypoxanthine and/or thymine to do this will not grow, multiply, and become visible colonies. This leaves the cells which are being selected for. (09 Oct 1997) |
| thymine | <biochemistry> Pyrimidine base found in DNA (in place of uracil of RNA). (18 Nov 1997) |
| thymine, 2-oxoglutarate dioxygenase | <enzyme> 5-hydroxymethyluracil,2-oxoglutarate dioxygenase was formerly EC 1.14.11.5; for this activity, substrate thymine may be replaced by uracil/analogs Chemical name: 5-hydroxymethyluracil,2-oxoglutarate dioxygenase /od/ thymine 7-hydroxylase Registry number: EC 1.14.11.6 Synonym: thymine 7-hydroxylase, alpha-ketoglutarate dioxygenase, thymine (26 Jun 1999) |
| thymine deoxyribonucleoside | <biochemistry> Term that is always used in practice for the nucleoside thymine deoxyriboside, not the riboside which naming of the other nucleosides might lead one to expect. (18 Nov 1997) |
| thymine deoxyribonucleotide | A component of DNA; originally and properly called thymidylic acid, but use of deoxy-is less ambiguous, as ribothymidylic acid is now known to exist. Synonym: thymine deoxyribonucleotide. (05 Mar 2000) |
| thymine dimer | <molecular biology> Dimer that can be formed in DNA by covalent linkage between two adjacent (cis) thymidine residues, in response to ultraviolet irradiation. Occurrence potentially mutagenic, although repair enzymes exist that can excise thymine dimers. See: xeroderma pigmentosum. (18 Nov 1997) |
| thymine nucleotide | A major constituent of DNA. Synonym: thymidine 5'-monophosphate, thymine nucleotide. (05 Mar 2000) |
| thymine nucleotides | Phosphate esters of thymidine in n-glycosidic linkage with ribose or deoxyribose, as occurs in nucleic acids. (12 Dec 1998) |
| DNA-directed DNA polymerase | <enzyme> DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair. Chemical name: Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) Registry number: EC 2.7.7.7 (12 Dec 1998) |
| A-DNA | A form of DNA in which the helix is right-handed and the overall appearance is short and broad. (05 Mar 2000) |
| a-form DNA | <molecular biology> One of several forms that can be assumed by a double helix. A-DNA is stable in dehydrated conditions. This form is less common than the dominant form found under physiological conditions -- beta-DNA. This form is also assumed by DNA-RNA hybrid helices and by regions of double-stranded RNA. It is a right-handed helix and is a more compact form than beta-DNA. (09 Oct 1997) |
Synonyms : G-T Mismatch-Specific Thymine DNA Glycosylase, Thymine Glycol DNA Glycosylase, Thymine Glycol Glycosylase, DNA Glycosylase, Thymine, G T Mismatch Specific Thymine DNA Glycosylase, Glycol Glycosylase, Thymine, Glycosylase, Thymine DNA
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