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teniposide <chemical> A cytotoxic semisynthetic derivative of podophyllotoxin that may be effective in cancer chemotherapy. It prevents cells from entering the prophase of mitosis and inhibits DNA synthesis.
Pharmacological action: antineoplastic agent, phytogenic, nucleic acid synthesis inhibitors.
Chemical name: Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
(12 Dec 1998)
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  • Teniposide - »õâ A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
    Synonyms : Bristol-Myers Brand of Teniposide, Bristol-Myers Squibb Brand of Teniposide, NSC-122819, Teniposide, (5a alpha, 9 alpha(S*))-Isomer, VM-26, Vumon, Bristol Myers Brand of Teniposide, Bristol Myers Squibb Brand of Teniposide, NSC 122819, NSC122819, VM 26, VM26
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E00140101 Teniposide
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teniposide An anticancer drug that is a podophyllotoxin derivative and belongs to the family of drugs called mitotic inhibitors.
Ãâó: www.stjude.org/glossary
teniposide A chemotherapy drug that inhibits cancer cell growth by interfering with the formation of DNA.
Ãâó: nydailynews.healthology.com/nydailynews/15836.htm
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