| SCPNT | Southern California Postrotary Nystagmus Test |
|---|---|
| SCSIT | Southern California Sensory Integration Test |
| STSA | Southern Thoracic Surgical Association |
| CAS | calcarine sulcus; calcific aortic stenosis; Cancer Attitude Survey; carbohydrate-active steroid; car... |
| CES-D | Center for Epidemiological Studies of Depression [scale] |
| ENSO | El Nino Southern Oscillation |
|---|---|
| SB | Southern Blot |
| SBMV | Southern bean mosaic virus |
| SBH | Southern blot hybridisation |
| SB | Southern blotting |
| africa, southern | The geographical area of africa comprising angola, botswana, lesotho, malawi, mozambique, namibia, south africa, swaziland, zambia, and zimbabwe. It includes what was formerly called south-west africa or german southwest africa but it was terminated in 1966 by a united nations resolution. (12 Dec 1998) |
|---|---|
| blot, southern | A common test for checking for a match between DNA molecules. DNA fragments are separated by agarose gel electrophoresis, transferred (blotted) onto membrane filters, and hybridised with complementary radiolabelled probes. The aim is to detect specific base sequenceswith the probes. Lest all of this sound esoteric, note that in the television series The X Files a Southern blot was done (in this case, to learn if some alien virus genome had been integrated into a person's genome). The Southern blot is named after its inventor, the British biologist M.E. Southern. There is also a Northern blot and a Western blot. (12 Dec 1998) |
| blotting, southern | A method (first developed by e.m. Southern) for detection of DNA that has been electrophoretically separated and immobilised by blotting on nitrocellulose or other type of paper or nylon membrane. (12 Dec 1998) |
| Southern | M.E., 20th century British biologist. See: Southern blot analysis. (05 Mar 2000) |
| southern blot | A technique used for searching for a specific DNA fragment. The process is as follows: 1. separate DNA fragments by gel electrophoresis 2. Change pH of gel to basic, thus allowing disruption of H-bonds 3. blot gel with nitrocellulose paper 4. Heat paper so as to fix DNA fragments 5. probe with labelled messenger RNA or cDNA 6. wash Complementary mRNA/cDNA fragments will have hybridised. (09 Oct 1997) |
| Southern blot analysis | A procedure to separate and identify DNA sequences; DNA fragments are separated by electrophoresis on an agarose gel, transferred (blotted) onto a nitrocellulose or nylon membrane, and hybridised with complementary (labelled) nucleic acid probes. (05 Mar 2000) |
| Southern blotting | <molecular biology, procedure> General term for the transfer of protein, RNA or DNA molecules from a relatively thick acrylamide or agarose gel or to a paper like membrane (usually nylon or nitrocellulose) by capilliarity or an electric field, preserving the spatial arrangment. Once on the membrane, the molecules are immobilised, typically by baking or by ultra violet irradiation and can then be detected at high sensitivity by hybridisation (in the case of DNA & RNA) or antibody labelling (in the case of protein). RNA blots are called Northern blots, DNA blots, Southern, protein blots, Western. (18 Nov 1997) |
| retrospective studies | Studies used to test aetiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. (12 Dec 1998) |
| pharmalogical studies | <pharmacology> Studies to assess the potential harmful or other effects of drugs (16 Dec 1997) |
| clinical studies | <pharmacology> Human studies that are designed to measure the safety, efficacy, and appropriate dosage of a new drug or biological. Clinical studies routinely involve the use of a placebo group that is given an inactive substance that looks like the test product. (14 Nov 1997) |
| cohort studies | Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesised to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics. (12 Dec 1998) |
| combination studies | <pharmacology> Studies in which a new drug is evaluated in combination with existing drugs. (09 Jan 1998) |
| multicenter studies | Controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children. (12 Dec 1998) |
| multivariate studies | The use of statistical techniques for the simultaneous investigations of the influence of several variables. (05 Mar 2000) |
| preclinical studies | <pharmacology> Studies in which a drug is tested on animals and in other non-human test systems. Safety information from such studies are used to support an investigational new drug application. (14 Nov 1997) |
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