| Scatchard plot | A method for analysing data for freely reversible ligand/receptor binding interactions. The graphical plot is: Bound ligand/Free ligand) against (Bound ligand), the slope gives the negative reciprocal of the binding affinity, the intercept on the x axis the number of receptors (Bound/Free becomes zero at infinite ligand concentration). The Scatchard plot is preferable to the Eadie Hoffstee plot for binding data because it is more dependent upon the values at high ligand concentration which will be the most reliable values. A nonlinear Scatchard plot is often taken to indicate heterogeneity of receptors, although this is not the only explanation possible. (18 Nov 1997) |
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| Scatchard, George | <person> U.S. Chemist and biochemist, 1892-1973. See: Scatchard plot. (05 Mar 2000) |
| Scatchard p. |
a graph used in analyzing reversible binding of ligands and receptors, based on the Hill equation where the Hill coefficient is 1.0 (i.e., successive ligands bind independently). The concentration of ligand is varied while that of the receptor is held constant and the ratio of bound to free ligand is plotted as a function of bound ligand.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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| Scatchard plot |
A graph used to find the equilibrium constant for a reaction such as A + B <=> AB. It is a graph of [AB]/[A] versus [AB], or any functions proportional to these quantities. The magnitude of the slope of the graph is the equilibrium constant.
Ãâó: www-analytik.chemie.uni-regensburg.de/Wolfbeis/tw/...
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