| BAT | basic aid training; best available technology; blunt abdominal trauma; brown adipose tissue |
|---|---|
| BBS | Barolet-Biedl syndrome; bashful bladder syndrome; benign breast syndrome; bilateral breath sounds; b... |
| BN | bladder neck; branchial neuritis; bronchial node; brown Norway [rat]; bulimia nervosa |
| Br | breech; bregma; bridge; bromine; bronchitis; brown; Brucella; brucellosis |
| brn | brown |
| BAT | Brown Adipose Tissue |
|---|---|
| B-N | Brown Norway |
| BN | Brown Norway rat |
| BRW | Brown-Robert-Wells |
| CY-BOCS | Children Yale-Brown Obsessive Compulsive Scale |
| Sanger Coulson method | The most popular method of DNA sequence determination (c.f. Maxam Gilbert sequencing). Starting with single stranded template DNA, a short complementary primer is annealed and extended by a DNA polymerase. The reaction is split into 4 tubes (called A, C, G or T) each containing a low concentration of the indicated dideoxy nucleotide, in addition to the normal deoxynucleotides. Dideoxynucleotides, once incorporated, block further chain extension and so each tube accumulates a mixture of chains of lengths determined by the template sequence. The 4 reactions are denatured and run out on an acrylamide sequencing gel in neighbouring lanes and the sequence read up the gel according to the order of the bands. (18 Nov 1997) |
|---|---|
| Sanger, Frederick | <person> English biochemist and twice Nobel laureate, *1918. See: Sanger's reagent, Sanger method. (05 Mar 2000) |
| Sanger method | The method for the sequencing of DNA employing an enzyme that can polymerase DNA and labelled nucleotides. (05 Mar 2000) |
| Sanger's reagent | A reagent used to combine with the free NH2 group of the NH2-terminal amino acid residue in a peptide, thus marking this residue; the combined forms are known as DNP-proteins, Dnp-aminoacyl, etc., the fluorine having been replaced to leave a dinitrophenyl residue (DNP, Dnp, or N2Ph-) attached to the NH2 group. Synonym: Sanger's reagent. Acronym: FDNB (05 Mar 2000) |
| acute ataxia | Generalised ataxia of abrupt onset, most often caused by drug intoxications, poisonings, or vestibular neuronitis. (05 Mar 2000) |
| algae, brown | Predominantly marine algae of the division phaeophyta, having chromatophores containing carotenoid pigments. Genera include ascophyllum, fucus, eisenia, petalonia, ectocarpus. (12 Dec 1998) |
| ataxia | <neurology> Failure of muscular coordination, irregularity of muscular action. Origin: Gr. Taxis = order (16 Dec 1997) |
| ataxia cordis | <cardiology> A condition where there is disorganised electrical conduction in the atria, resulting in ineffective pumping of blood into the ventricle. Acronym: AF (02 Jan 1998) |
| ataxia of calves | A specific cerebellar ataxia in the Jersey breed, probably a recessive genetic trait. (05 Mar 2000) |
| ataxia of lambs | Myelination failure seen in ewes on a copper-deficient diet. (05 Mar 2000) |
| ataxia-telangiectasia | <neurology, oncology> An intriguing autosomal recessive disorder in which a single defective gene produces myriad and protean effects, presents with cerebellar ataxia, telangiectasias in the eyes and skin, immune deficiency and autoimmune phenomena, propensity for lymphoid and other malignancies, excessive sensitivity to ionising radiation, increased serum alpha-fetoprotein concentrations and a tendency for chromosome breakage and translocation. A syndrome characterised by choreoathetosis beginning in childhood, progressive cerebellar ataxia, telangiectasis of conjunctiva and skin, slowly progressive mental deterioration and increasing cerebellar degeneration. There is evidence that heterozygotes show an increased susceptibility to malignancy as well, with breast cancer often cited. The gene was localised by linkage studies to chromosome 11q22-23, and recently cloned, revealing it to be homologous to the PI-3 kinase family so that prenatal diagnosis by RFLP analysis is possible. Other related genes are suspected to exist. Diagnosis in affected patients is made on clinical grounds, by detection of high concentrations of alpha-fetoprotein, and by a specialised cell culture assay for radiosensitivity and atypical radioresistant DNA synthesis. These cell culture methods are also used for prenatal diagnosis. A characteristic autopsy feature of ataxia-telangiectasia is the presence of empty basket cells in the cerebellum which results from degeneration of the previously contained Purkinje cells. Inheritance: autosomal recessive. (16 Dec 1998) |
| ataxia telangiectasia syndrome | ataxia telangiectasia |
| Bismarck brown R | A diazo dye similar to Bismarck brown Y. (05 Mar 2000) |
| Bismarck brown Y | A diazo dye used for staining mucin and cartilage in histologic sections, in the Papanicolaou technique for vaginal smears, and as one of Kasten's Schiff-type reagents in the PAS and Feulgen stains. Synonym: vesuvin. Origin: Ger. Bismarckbraun, after Otto von Bismarck, Ger. Chancellor (05 Mar 2000) |
| Blair-Brown graft | A split-thickness graft of intermediate thickness. (05 Mar 2000) |
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