| FCRC | Frederick Cancer Research Center |
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| Sanger, Frederick | <person> English biochemist and twice Nobel laureate, *1918. See: Sanger's reagent, Sanger method. (05 Mar 2000) |
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| Sanger Coulson method | The most popular method of DNA sequence determination (c.f. Maxam Gilbert sequencing). Starting with single stranded template DNA, a short complementary primer is annealed and extended by a DNA polymerase. The reaction is split into 4 tubes (called A, C, G or T) each containing a low concentration of the indicated dideoxy nucleotide, in addition to the normal deoxynucleotides. Dideoxynucleotides, once incorporated, block further chain extension and so each tube accumulates a mixture of chains of lengths determined by the template sequence. The 4 reactions are denatured and run out on an acrylamide sequencing gel in neighbouring lanes and the sequence read up the gel according to the order of the bands. (18 Nov 1997) |
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| Sanger method | The method for the sequencing of DNA employing an enzyme that can polymerase DNA and labelled nucleotides. (05 Mar 2000) |
| Sanger's reagent | A reagent used to combine with the free NH2 group of the NH2-terminal amino acid residue in a peptide, thus marking this residue; the combined forms are known as DNP-proteins, Dnp-aminoacyl, etc., the fluorine having been replaced to leave a dinitrophenyl residue (DNP, Dnp, or N2Ph-) attached to the NH2 group. Synonym: Sanger's reagent. Acronym: FDNB (05 Mar 2000) |
| Banting, Frederick | <person> Banting received his medical degree from Toronto and served in the Canadian armed services during the First World War. He practiced orthopaedic surgery following the war, but was not too successful because of his disinterest. He asked the Professor of Physiology at the University of Toronto if he could work on a problem he was interested in, and when he explained his idea relative to the pancreas, the professor poopooed his experiment. Regardless, he was given a dirty little lab in which to work. Banting was 30, and he was assisted by a 23-year-old second-year medical student, Charles H. Best. After eight months, in 1922, these two isolated insulin and published their discovery, which revolutionised the treatment for diabetes mellitus. In 1923, the Nobel Prize for Medicine was given to Banting and the physiology professor who loaned him the dirty lab to work in, J.J.R. Macleod. In 1924, Banting was knighted. Unfortunately, he was killed in an airplane accident in 1944. Lived: 1891-1944. (15 Nov 1997) |
| Gaenslen, Frederick | <person> U.S. Surgeon, 1877-1937. See: Gaenslen's sign. (05 Mar 2000) |
| Verhoeff, Frederick | <person> U.S. Ophthalmologist, 1874-1968. See: Verhoeff's elastic tissue stain. (05 Mar 2000) |
| Pavy, Frederick | <person> English physician, 1829-1911. See: Pavy's disease. (05 Mar 2000) |
| Griffith, Frederick | <person> A bacteriologist who discovered that if he put pathogenic (disease-causing) pneumococcus bacteria which had been killed by heat in with nonpathogenic pneumococcus bacteria which were alive, then the live, nonpathogenic bacteria would become pathogenic. His work became the groundwork for other scientists to discover that DNA was the factor which transformed the bacteria. Lived: 1881-1941. (13 Nov 1997) |
| Ward, Frederick | <person> British osteologist, 1818-1877. See: Ward's triangle. (05 Mar 2000) |
| Weber, Frederick Parkes | <person> English physician, 1863-1962. See: Weber-Christian disease, Weber-Cockayne syndrome, Rendu-Osler-Weber syndrome, Sturge-Kalischer-Weber syndrome, Sturge-Weber disease, Sturge-Weber syndrome, Klippel-Trenaunay-Weber syndrome. (05 Mar 2000) |
| Hopkins, Frederick | <person> An English biochemist and Nobel laureate. Lived: 1861-1947. See: Benedict-Hopkins-Cole reagent. (05 Mar 2000) |
| Novy, Frederick | <person> U.S. Bacteriologist, 1864-1957. See: Novy and MacNeal's blood agar. (05 Mar 2000) |
| Dick, George Frederick | <person> U.S. Internist, 1881-1967. See: Dick method, Dick test, Dick test toxin. (05 Mar 2000) |
| Donnan, Frederick | <person> English physical chemist, 1870-1956. See: Donnan equilibrium, Gibbs-Donnan equilibrium. (05 Mar 2000) |
| Edridge-Green, Frederick | <person> English ophthalmologist, 1863-1953. See: Edridge-Green lamp. (05 Mar 2000) |
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