| Parvoviridae | <virology> Class II viruses. The genome of these simple viruses is single stranded DNA and they have an icosahedral nucleocapsid. The autonomous parvoviruses have a negative strand DNA and include viruses of vertebrates and arthropods. The defective Adeno associated viruses cannot replicate in the absence of helper adenoviruses and have both positive and negative stranded genomes, but packaged in separate virions. (18 Nov 1997) |
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| parvoviridae infections | Virus infections caused by the parvoviridae. (12 Dec 1998) |
Synonyms :
Synonyms : Infections, Parvoviridae, Infections, Parvovirus, Infection, Parvoviridae, Infection, Parvovirus, Parvoviridae Infection, Parvovirus Infection
| Parvoviridae |
the parvoviruses: a family of DNA viruses having a nonenveloped virion 1826 nm in diameter composed of 60 copies of the capsid protein with icosahedral symmetry. The genome consists of a single molecule of linear single-stranded DNA (MW 1.52.2 × 106, size 46 kb). Viruses contain 24 major polypeptides, depending on the species, and are resistant to heat, lipid solvents, deoxycholate, and nucleases but sensitive to formalin, β-propiolactone, hydroxylamine, oxidizing agents, and ultraviolet radiation. Replication and assembly occur in the nucleus and require S-phase cellular function in the host cell or the presence of helper virus. Host range is narrow and transmission may be vertical or by mechanical vectors. There are two subclasses: Densovirinae, comprising genera that infect invertebrates, and Parvovirinae, comprising genera that infect vertebrates.
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