| NP | nasopharynx, nasopharyngeal; near point; necrotizing pancreatitis; neonatal-perinatal; neuritic plag... |
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| NPD | narcissistic personality disorder; natriuretic plasma dialysate; negative pressure device; Niemann-P... |
| PGS | peristent gross splenomegaly; Pettigrew syndrome; plant growth substance; postsurgical gastroparesis... |
| TSS | toxic shock syndrome; tropical splenomegaly syndrome |
| TSS | Tropical Splenomegaly Syndrome |
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| NPC | NIEMANN: Pick disease type C |
| NPD | Niemann Pick disease |
| NP-C | Niemann-Pick Type C |
| Niemann's splenomegaly | Enlargement of spleen occurring in Niemann-Pick disease. (05 Mar 2000) |
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| Niemann, Albert | <person> German physician, 1880-1921. See: Niemann-Pick cell, Niemann-Pick disease, Niemann disease, Niemann's splenomegaly. (05 Mar 2000) |
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| Niemann disease | <disease> A family of severe lysosomal storage diseases resulting in an accumulation of sphingomyelin and other phospholipids in the reticuloendothelial system. The best studied forms are due to deficiency of sphingomyelinase and it is more common in Ashkenazi Jews than other groups. Clinical signs include foam cells in the blood and marrow, hepatosplenomegaly and neurologic degeneration. Diagnosis is confirmed by enzyme assay on leukocytes or fibroblasts and specific mutations in the gene are now recognised. (29 Dec 1997) |
| Niemann-Pick cell | A relatively large, rounded or polygonal, mononuclear cell, with indistinctly or palely staining, foamlike cytoplasm that contains numerous droplets of a phosphatide, sphingomyelin; such cell's are widely distributed in the spleen and other tissues, especially those rich in reticuloendothelial components, in patients with Niemann-Pick disease. Synonym: Niemann-Pick cell. (05 Mar 2000) |
| Niemann-Pick disease | <disease> A family of severe lysosomal storage diseases resulting in an accumulation of sphingomyelin and other phospholipids in the reticuloendothelial system. The best studied forms are due to deficiency of sphingomyelinase and it is more common in Ashkenazi Jews than other groups. Clinical signs include foam cells in the blood and marrow, hepatosplenomegaly and neurologic degeneration. Diagnosis is confirmed by enzyme assay on leukocytes or fibroblasts and specific mutations in the gene are now recognised. (29 Dec 1997) |
| massive splenomegaly | <radiology> Malaria, CML, myelofibrosis and myeloid metaplasia, Kala azar, schistosomiasis, storage diseases: Gaucher, Niemann-Pick, thalassaemia major (Cooley's anaemia), some spleen cysts (12 Dec 1998) |
| congestive splenomegaly | Enlargement of the spleen due to passive congestion; sometimes used as a synonym for Banti's syndrome. (05 Mar 2000) |
| haemolytic splenomegaly | Splenomegaly associated with congenital haemolytic jaundice. (05 Mar 2000) |
| hyperreactive malarious splenomegaly | A syndrome characterised by persistent splenomegaly, exceptionally high serum IgM and malaria antibody levels, and hepatic sinusoidal lymphocytosis; believed to be a disturbance in the T-lymphocyte control of the humoral response to recurrent malaria. Synonym: tropical splenomegaly syndrome. (05 Mar 2000) |
| splenomegaly | <clinical sign> Enlargement of the spleen. Origin: Gr. Megas = large (18 Nov 1997) |
| Egyptian splenomegaly | Term sometimes used as a synonym for schistosomiasis mansoni, although hepatomegaly and fibrosis are more consistently found than is an enlarged spleen. (05 Mar 2000) |
| tropical splenomegaly | A chronic disease, occurring in India, Assam, China, the area formerly known as the Mediterranean littoral areas, the Middle East, India, Pakistan, China, South and Central America, Asia, Africa caused by Leishmania donovani and transmitted by the bite of an appropriate species of sandfly of the genus Phlebotomus or Lutzomyia; the organisms grow and multiply in macrophages, eventually causing them to burst and liberate amastigote parasites which then invade other macrophages; proliferation of macrophages in the bone marrow causes crowding out of erythroid and myeloid elements, resulting in leukopenia, and anaemia, splenomegaly, and hepatomegaly which are characteristic, along with enlargement of lymph nodes; fever, fatigue, malaise, and secondary infections also occur; different strains of leishmaniasis donovani occur; leishmaniasis infantum in Eurasia, leishmaniasis chagasi in Latin America. Synonym: Assam fever, black sickness, Burdwan fever, cachectic fever, Dumdum fever, kala azar, tropical splenomegaly. (05 Mar 2000) |
| tropical splenomegaly syndrome | A syndrome characterised by persistent splenomegaly, exceptionally high serum IgM and malaria antibody levels, and hepatic sinusoidal lymphocytosis; believed to be a disturbance in the T-lymphocyte control of the humoral response to recurrent malaria. Synonym: tropical splenomegaly syndrome. (05 Mar 2000) |
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