| MMM | see 3-M [syndrome]; microsome-mediated mutagenesis; myelofibrosis with myeloid metaplasia; myeloscle... |
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| GPC | gastric parietal cell; gel permeation chromatography; giant papillary conjunctivitis; glycophorin C;... |
| HPCA | human progenitor cell antigen |
| PPP | pain perception profile; palatopharyngoplasty; palmoplantar pustulosis; pentose phosphate pathway; p... |
| LAK T cells | Lymphokine Activated Killer T cells |
| BPC | Blood progenitor cells |
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| CPC | Circulating progenitor cells |
| HPC | Haematopoietic progenitor cells |
| HPC | Haemopoietic progenitor cells |
| HSPC | hematopoietic stem-/progenitor cells |
| erythroid progenitor cells | Committed, erythroid stem cells derived from myeloid stem cells. The progenitor cells develop in two phases: erythroid burst-forming units (bfu-e) followed by erythroid colony-forming units (cfu-e). Bfu-e differentiate into cfu-e on stimulation by erythropoietin, and then further differentiate into erythroblasts when stimulated by other factors. (12 Dec 1998) |
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| progenitor | A precursor, ancestor; one who begets. Origin: L. (05 Mar 2000) |
| progenitor cell | <cell biology> In development a parent cell that gives rise to a distinct cell lineage by a series of cell divisions. (18 Nov 1997) |
| progenitor cell transplant | (stem cell transplant, blood cell transplant): The transplantion of parent cells which may give rise to progeny (daughter cells) which erve more specialised functions. Transplants may be from the peripheral blood or bone marrow. The patient himself/herself may be the donor (autologous transplant), a (genetically) compatible relative or individual (allogeneic transplant). (16 Dec 1997) |
| O 2A progenitor | Bipotential progenitor cells in rat optic nerve that give rise initially to oligodendrocytes and then to type 2 astrocytes. Production of type 2 astrocytes from O 2A progenitor cells in vitro is triggered by ciliary neurotrophic factor (CNTF). (18 Nov 1997) |
| acute myeloid leukaemia | <haematology> A rapidly progressing cancer of the blood affecting immature cells of the bone marrow, usually of the white cell population. It is much more common in adults than in children. Symptoms include fatigue, weight loss, fevers, weakness, pallor, bone pains, bleeding gums, nosebleeds, easy bruising, enlarged lymph nodes and joint pains. Treatment includes chemotherapy and/or bone marrow transplant. This leukaemia demonstrates granulocyte differentiation, eosinophilia and Auer rods and is associated with a reciprocal translocation between 8 and 21 (q22;q22), which is the most common translocation in acute myeloid leukaemia and is found more often in younger patients than in older patients. The oncogene involved in this translocation is AML1, which can be detected by Southern blot. Numerical abnormalities, particularly monosomy-7, trisomy-4, trisomy-8, trisomy-21, -Y, monosomy-7 and deletions of the long arms of chromosomes 5 and 7 are quite common in all acute myeloid leukaemia and not restricted to any one FAB classification. Many of these abnormalities are observed at diagnosis and at later stage disease, particularly after chemotherapy. Prognosis is generally more favorable than in FAB-M2 patients showing no translocation, because the latter patients show better remission rates for longer periods of time. Immunophenotyping is useful in diagnosis and expression of one or more of the myeloid antigens CD13, CD14 or CD33 must be detected to make a diagnosis of acute myeloid leukaemia. Acronym: AML Incidence: 2,000 new cases per year in the UK. Origin: Gr. Haima = blood (07 Apr 1998) |
| agnogenic myeloid metaplasia | A progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow in multiple sites outside the bone marrow. Typically, there is enlargement of the spleen and a gradual replacement of the bone marrow elements by fibrosis (scarring), progressive anaemia and variable changes in the number of white blood cells and platelets. Diagnosis is by bone marrow biopsy. There is no definitive treatment for this disorder that has been shown to affect life span favorably. Origin: Gr. Plassein = to form (27 Sep 1997) |
| chronic myeloid leukaemia | <haematology> A leukaemia which is initially slowly-progressing. There are approximately 650 new cases each year in the UK. It is characterised by the presence of large numbers of abnormal mature granulocytes, circulating in the blood. Synonym: chronic granulocytic leukaemia. Acronym: CML Origin: Gr. Haima = blood (12 Jan 1998) |
| myeloid | Collective term for the nonlymphocyte groups of white blood cells. It includes cells from the granulocyte, monocyte and platelet lineages. (13 Nov 1997) |
| myeloid cell | <haematology, pathology> One of the two classes of marrow derived blood cells, includes megakaryocytes, erythrocyte precursors, mononuclear phagocytes and all the polymorphonuclear granulocytes. That all these are ultimately derived from one stem cell lineage is shown by the occurrence of the Philadelphia chromosome in these, but not lymphoid, cells. most authors tend, however, to restrict the term myeloid to mononuclear phagocytes and granulocytes and commonly distinguish a separate erythroid lineage. (12 May 1997) |
| myeloid metaplasia | A progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow in multiple sites outside the bone marrow. Typically, there is enlargement of the spleen and a gradual replacement of the bone marrow elements by fibrosis (scarring), progressive anaemia and variable changes in the number of white blood cells and platelets. Diagnosis is by bone marrow biopsy. There is no definitive treatment for this disorder that has been shown to affect life span favorably. Origin: Gr. Plassein = to form (27 Sep 1997) |
| myeloid sarcoma | <tumour> A malignant tumour of immature myeloid cells, frequently subperiosteal, associated with or preceding granulocytic leukaemia. See: chloroma. Synonym: myeloid sarcoma. (05 Mar 2000) |
| myeloid series | The granulocytic and the erythrocytic series. (05 Mar 2000) |
| myeloid tissue | Bone marrow consisting of the developmental and adult stages of erythrocytes, granulocytes, and megakaryocytes in a stroma of reticular cells and fibres, with sinusoidal vascular channels. (05 Mar 2000) |
| primary myeloid metaplasia | Myeloid metaplasia occurring as the primary condition, often in association with myelofibrosis. Synonym: agnogenic myeloid metaplasia. (05 Mar 2000) |
Synonyms : Cell, Myeloid Progenitor, Cell, Myeloid Stem, Cells, Myeloid Progenitor, Cells, Myeloid Stem, Myeloid Progenitor Cell, Myeloid Stem Cell, Myeloid Stem Cells, Progenitor Cell, Myeloid, Progenitor Cells, Myeloid, Stem Cell, Myeloid
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