| genes, myc | Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumourigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8. (12 Dec 1998) |
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| myc | <oncogene> This proto-oncogene causes cancers (carcinomas and sarcomas) and is found in the avian myelocytomatosis virus. It has been identified in several avian tumours, and encodes a nuclear protein with a leucine zipper motif. If translocated, it can cause Burkitt's lymphoma, if amplified, it can cause lung, breast, and cervical carcinomas. It is found in both chickens and has an analogue in humans which is located on the long arm of chromosome 8. (24 Mar 1998) |
| myc proteins | <molecular biology> Family of proteins involved in control of translation, have a C terminal basic helix loop helix zipper domain. Myc Max heterodimers specifically bind the sequence CACGTG with higher affinity than homodimers of either. (18 Nov 1997) |
| proto-oncogene proteins c-myc | Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumourigenesis. (12 Dec 1998) |
| N myc | <oncogene> Oncogene, related to myc, found in neuroblastomas. (18 Nov 1997) |
| oncogene protein p55(v-myc) | Transforming protein coded by myc oncogenes. The v-myc protein has been found in several replication-defective avian retrovirus isolates which induce a broad spectrum of malignancies. (12 Dec 1998) |
| L myc | <oncogene> Relative of the myc proto-oncogene overexpressed in lung carcinoma. (18 Nov 1997) |
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