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kernicterus <paediatrics> Disorder due to jaundice in a newborn baby with high blood levels of the pigment bilirubin that is deposited in the brain resulting in damage. The level of bilirubin is monitored in newborns to determine whether treatment is needed to prevent kernicterus. With brain affected, it is also called bilirubin encephalopathy.
(12 Dec 1998)
rh isoimmunization The process by which foetal rh+ erythrocytes enter the circulation of an rh- mother during delivery, causing her to produce IgG antibodies, which can cross the placenta and destroy the erythrocytes of rh- foetuses in subsequent pregnancies.
(12 Dec 1998)
isoimmunization Development of a significant titre of specific antibody as a result of antigenic stimulation with material contained on or in the red blood cells of another individual of the same species; e.g., isoimmunization is likely to occur when an Rh-negative person is treated with a transfusion of Rh-positive blood from another human being, or an Rh-negative woman has a pregnancy in which the foetus inherits Rh-positive red blood cells.
(05 Mar 2000)
due date The estimated calendar date when a baby will be born, the date the baby is due to be born. It is also called the estimated date of confinement (EDC).
(12 Dec 1998)
dystonia, focal, due to blepharospasm The second most common focal dystonia, the involuntary, forcible closure of the eyelids. The first symptoms may be uncontrollable blinking. Only one eye may be affected initially, but eventually both eyes are usually involved. The spasms may leave the eyelids completely closed causing functional blindness even though the eyes and vision are normal.
(12 Dec 1998)
dystonia, focal, due to torticollis Spasmodic torticollis, or torticollis, is the most common of the focal dystonias. In torticollis, the muscles in the neck that control the position of the head are affected, causing the head to twist and turn to one side. In addition, the head may be pulled forward or backward.
(12 Dec 1998)
thrombotic disease due to protein c deficiency Protein C is a protein in plasma that enters into the cascade of biochemical events leading to the formation of a clot. Deficiency of protein c results in thrombotic (clotting) disease and excess platelets with recurrent thrombophlebitis (inflammation of the vein that occurs when a clot forms). The clot can break loose and travel through the blood stream (thromboembolism) to the lungs causing a pulmonary embolism, brain causing a stroke (cerebrovascular accident), heart causing an early heart attack, skin causing what in the newborn is called neonatal purpura fulminans, the adrenal gland causing haemorrhage with abdominal pain, abnormally low blood pressure (hypotension), and salt loss. Protein c deficiency is due to possession of one gene (heterozygosity) in chromosome band 2q13-14. The possession of two such genes (homozygosity) is usually lethal.
(12 Dec 1998)
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