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  • Immunoglobulins
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FAB fast atom bombardment; formalin ammonium bromide; fragment, antigen-binding [of immunoglobulins]; Fr...
Fab fragment, antigen-binding [of immunoglobulins]
F(ab')2 fragment, antigen-binding [of immunoglobulins]
Fabc fragment, antigen and complement binding [of immunoglobulins]
GAME immunoglobulins G, A, M, and E
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SIgA Secretory immunoglobulins A
SmIg Surface membrane immunoglobulins
TSI Thyroid Stimulating Immunoglobulins
TBII Thyrotrophin binding inhibiting immunoglobulins
CancerWEB ¿µ¿µ ÀÇÇлçÀü ¸ÂÃã °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
immunoglobulins Any of the structurally related glycoproteins that function as antibodies. They are divided into five classes (IgA, IgD, IgE, IgG, IgM) on the basis of structure and biological activity.
(12 Dec 1998)
immunoglobulins, alpha-chain Heavy chains found in the fab and fc fragments of IgA and having a molecular weight of approximately 58 kD. They contain about 470 amino acid residues arranged in four domains and an oligosaccharide component bound covalently to the fc fragment.
(12 Dec 1998)
immunoglobulins, delta-chain Heavy chains found in the fab and fc fragments of IgD and having a molecular weight of approximately 64 kD. They contain about 500 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the fc fragment.
(12 Dec 1998)
immunoglobulins, epsilon-chain Heavy chains found in the fab and fc fragments of IgE and having a molecular weight of approximately 72 kD. They contain about 550 amino acid residues arranged in five domains and about three times more carbohydrate than the heavy chains of IgA, IgD, and IgG.
(12 Dec 1998)
immunoglobulins, fab Antigen-binding fragments composed of one entire light chain and about half of one of the heavy chains, linked to each other by disulfide bonds. Fab contains the antigen binding site which is part of the variable region of the immunoglobulin molecule.
(12 Dec 1998)
immunoglobulins, fc Crystallizable fragments composed of the carboxy-terminal halves of both heavy chains linked to each other by disulfide bonds. Fc fragments are responsible for the effector functions of antibodies (complement fixation, binding to cell membranes, and placental transport).
(12 Dec 1998)
immunoglobulins, gamma-chain Heavy chains found in the fab and fc fragments of IgG and having a molecular weight of approximately 51 kD. They contain about 450 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the fc fragment. The gamma chains of the four IgG subgroups are not identical, but resemble each other more closely than the heavy chains of a different immunoglobulin.
(12 Dec 1998)
immunoglobulins, heavy-chain Major components of immunoglobulin molecules. They are the larger of the two types of polypeptide chains responsible for the biological and immunological properties of the different immunoglobulins. They differ according to the class of ig from which they were isolated, contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kD. One ig molecule comprises two heavy and two light chains.
(12 Dec 1998)
immunoglobulins, intravenous Immunoglobulin preparations used in intravenous infusion, containing primarily IgG. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including paediatric aids, primary hypergammaglobulinaemia, scid, cytomegalovirus infections in transplant recipients, chronic lymphocytic leukaemia, kawasaki syndrome, infection in neonates, and idiopathic thrombocytopenic purpura.
(12 Dec 1998)
immunoglobulins, j-chain The immunoglobulin fragments found in the light chain fractions of secretory IgA and polymeric IgM in a ratio of one j chain per one IgA dimer or one IgM pentamer. It is a polypeptide with a molecular weight of about 17 kD and probably serves either to bind the components of the globulins together or to transfer the globulins across membranes.
(12 Dec 1998)
immunoglobulins, kappa-chain One of the light chains of the immunoglobulins with a molecular weight of approximately 22 kD. They constitute about 60% of all light chains and can be recognised serologically as well as by their specific amino acid sequence.
(12 Dec 1998)
immunoglobulins, lambda-chain One of the light chains of the immunoglobulins with a molecular weight of approximately 22 kD. They constitute about 40% of all light chains and can be recognised serologically as well as by their specific amino acid sequence.
(12 Dec 1998)
immunoglobulins, light-chain Polypeptide chains, consisting of 211 to 217 amino acid residues, isolated from immunoglobulins and having a molecular weight of approximately 22 kD. There are two major types of light chains, kappa and lambda. In man they are found in a ratio of 60% to 40%, respectively. Both chains consist of linear repeating, similar, but not identical, segments of about 110 amino acid residues. In each segment a disulfide bond establishes a tightly folded approximately 60-membered loop or domain. Adjacent domains are linked by less tightly folded regions. Both light chains contain two such domains. Two light and two heavy chains make one immunoglobulin molecule, but both light chains in one ig are of the same type.
(12 Dec 1998)
immunoglobulins, mu-chain Heavy chains found in the fab and fc fragments of IgM and having a molecular weight of approximately 72 kD. They contain about 57 amino acid residues arranged in five domains and have more oligosaccharide branches and a higher carbohydrate content than the heavy chains of IgG.
(12 Dec 1998)
immunoglobulins, surface Immunoglobulins bound to the surface of lymphocytes.
(12 Dec 1998)
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thyroid-stimulating immunoglobulins In Graves' disease, the antibodies to TSH receptors in the thyroid gland. These antibodies are produced by B-lymphocytes and stimulate the receptors, causing hyperthyroidism. Formerly known as LATS (long-acting thyroid stimulator).
(05 Mar 2000)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 3 ÆäÀÌÁö: 1
  • Immunoglobulins - »õâ Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
    Synonyms : Immunoglobulin
  • Immunoglobulins, Intravenous - »õâ Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.
    Synonyms : Alphaglobin, Endobulin, Gamimmune, Gamimmune N, Gamimune, Gamimune N, Gammagard, Gammonativ, Globulin-N, IV Immunoglobulins, Immune Globulin, Intravenous, Intraglobin, Intraglobin F, Intravenous IG, Iveegam, Modified Immune Globulin (Anti-Echovirus Antibody)
  • Immunoglobulins, Thyroid-Stimulating - »õâ Autoantibodies that bind to the thyroid-stimulating hormone (TSH) receptor (RECEPTORS, THYROTROPIN) on thyroid epithelial cells. The autoantibodies mimic TSH causing an unregulated production of thyroid hormones characteristic of GRAVES DISEASE.
    Synonyms : Immunoglobulin, Thyroid-Stimulating, Thyroid Stimulating Antibody, Thyroid-Stimulating Immunoglobulin, Antibody, Thyroid Stimulating, Immunoglobulin, Thyroid Stimulating, Stimulating Antibody, Thyroid, Thyroid Stimulating Antibodies
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