| ¿µ¹® | diabetic nephropathy | ÇÑ±Û | ´ç´¢º´ÄáÆÏº´Áõ |
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| AAN | AIDS-associated nephropathy; alpha-amino nitrogen; American Academy of Neurology; American Academy o... |
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| Ig | Immuno-globulin IgA; Immuno-globulin A; (27)(30)60(100) - (170)(80)(250)380 mg/dL |
| IGA | infantile genetic agranulocytosis |
| IgA | immunoglobulin A |
| S-IgA | secretory immunoglobulin A |
| IgA NP | IgA nephropathy |
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| IgA-D | IgA deficiency |
| IgA GN | IgA glomerulonephritis |
| IgA-IC | IgA immune complex |
| IgA RF | IgA rheumatoid factor |
| IgA nephropathy | <nephrology, pathology> This is a form of glomerulonephritis that results from the deposition of circulating IgA antibody in the kidney tissues. Inflammation of the glomerulus (glomerulonephritis) is the result. This condition may present as acute glomerulonephritis, chronic glomerulonephritis or rapidly progressive glomerulonephritis. Berger's is usually detected in an individual with one or two bouts of bloody urine (usually begins during or soon after a respiratory infection) and no other symptoms of renal disease. Only rarely, will Berger's disease permanently affect kidney function and progress to chronic renal failure. This renal disorder more commonly affects males in the 16-40 age group. Origin: Gr. Pathos = disease (27 Sep 1997) |
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| glomerulonephritis, IgA | Chronic form of glomerulonephritis characterised by recurring haematuria with only slight proteinuria and by deposits of IgA immunoglobulin in the mesangial areas of the renal glomeruli. It usually occurs in young males. (12 Dec 1998) |
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| secretory component of IgA | <immunology, protein> A polypeptide chain of about 60 kD that aids secretion of the IgA, a portion of the IgA receptor on the plasmalemma of the inner side of the epithelial cells lining the gut, which is proteolysed when the IgA receptor complex has travelled through the cell after receptor mediated endocytosis at the inner face, to the outer (luminal) face. (18 Nov 1997) |
| IgA | <immunology> Major class of immunoglobulin of external secretions in mammals, also found in serum and body fluids such as tears and saliva and in the respiratory, reproductive, urinary and gastrointestinal tracts. Immunoglobulin A protects the bodys mucosal surfaces from infection and in secretions, it is found as a dimer (400 kD) joined by a short J chain and linked to a secretory portion or transport piece. In serum found as a monomer (170 kD). Immunoglobulin A is the main mechanism for providing local immunity against infections in the gut or respiratory tract and may act by reducing the binding between an immunoglobulin A coated micro organism and a host epithelial cell. Present in human colostrum but not transferred across the placenta. Have heavy chains. (30 Mar 1998) |
| IgA deficiency | A dysgammaglobulinaemia characterised by a deficiency of IgA. (12 Dec 1998) |
| IgA, secretory | The principle ig found in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. It is composed of two to four molecules of 7s IgA and one molecule each of j chain and secretory component (sc), also called secretory piece. Molecular weight appr. 400,000. (12 Dec 1998) |
| IgA-specific serine endopeptidase | <enzyme> Extracellular microbial enzymes whose only substrate is human IgA of the iga1 subclass; cleave the immunoglobulin at a specific internal prolyl-threonyl peptide bond in the heavy chain to yield intact faba and fca fragments; consider also EC 3.4.24.13 Registry number: EC 3.4.21.72 Synonym: immunoglobulin a(1) protease, iga1 protease, immunoglobulin a1 protease, IgA protease (26 Jun 1999) |
| linear IgA bullous disease in children | A rare self-limiting bullous disease, chiefly of the trunk, perioral, and pelvic areas, with onset in the first decade, successively less severe recurrences, and total remission at adolescence; linear epidermal basement membrane zone deposit of IgA is found in involved and in normal skin. Synonym: linear IgA bullous disease in children. (05 Mar 2000) |
| aids-associated nephropathy | Renal syndrome in human immunodeficiency virus-infected patients characterised by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients. (12 Dec 1998) |
| analgesic nephropathy | <nephrology, pathology> A form of kidney damage which can occur from the overexposure to certain analgesics (for example acetaminophen, salicylates and non-steroidal anti-inflammatory agents). In most cases analgesic use is excessive in dosing or chronicity of use. Complications include acute renal failure. See: interstitial nephritis. Origin: Gr. Pathos = disease (27 Sep 1997) |
| balkan nephropathy | A tubulointerstitial disease of unknown aetiology occurring in a limited geographic area including adjacent regions of romania, bulgaria, and yugoslavia. (12 Dec 1998) |
| reflux nephropathy | <nephrology> A condition where the chronic backup of urine into a kidney results in kidney damage. Urine is forced out of the bladder and back toward kidney. This condition occurs most commonly in children who have congenital abnormalities of the urinary tract. Symptoms include back pain, flank, pain, abdominal pain, urinary frequency or urgency and blood in the urine. Other symptoms include nausea, fever and chills, most often indicating a kidney infection has occurred. Diagnosis is frequently confirmed by voiding cystourethrogram. Surgery is often required to correct the reflux of urine. Origin: Gr. Pathos = disease (27 Sep 1997) |
| membranous nephropathy | <pathology> A kidney disease that occurs due to inflammation of the kidney glomerulus and its basement membrane. The exact cause is unknown but it appears to be related to the deposition of immune complexes in the basement membrane leading to thickening of the capillary walls. This disorder is a common cause of nephrotic syndrome an is usually how the disease manifests. Risk factors include primary renal disease, malaria, hepatitis B, lupus, syphilis, cancers and non-Hodgkin's lymphomas. Risks also include exposure to some medications such as gold compounds and penicillamine. Mercury, trimethadione and some skin-lightening creams have also been implicated. Treatment includes systemic corticosteroids and immunosuppressive agents. (26 Mar 1998) |
| hereditary deafness and nephropathy | <nephrology, pathology> An inherited disorder involving damage to the kidneys, haematuria and hearing loss. In some individuals vision may also be affected. This genetic disease is uncommon. Symptoms include loss of hearing, abnormal colour to urine, swelling, cough and decline in vision. Inheritance: sex-linked autosomal dominant. Incidence: 1 in 50,000. Origin: Gr. Pathos = disease (27 Sep 1997) |
| hypokalaemic nephropathy | Vacuolation of the epithelial cytoplasm of renal convoluted tubules in patients seriously depleted of potassium; vacuoles do not contain fat or glycogen, concentrating ability is impaired, polyuria and polydipsia are common, and pyelonephritis may develop. Synonym: vacuolar nephrosis. (05 Mar 2000) |
| nephropathy | <nephrology, urology> Any disease of the kidneys. Origin: Gr. Pathos = disease (18 Nov 1997) |
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