| S-IgA | secretory immunoglobulin A |
|---|---|
| PSP | pancreatic spasmolytic peptide; paralytic shellfish poisoning; parathyroid secretory protein; period... |
| Ig | Immuno-globulin IgA; Immuno-globulin A; (27)(30)60(100) - (170)(80)(250)380 mg/dL |
| IGA | infantile genetic agranulocytosis |
| IgA | immunoglobulin A |
| S-IgA | Secretory IgA |
|---|---|
| IgA-D | IgA deficiency |
| IgA GN | IgA glomerulonephritis |
| IgA-IC | IgA immune complex |
| IgA NP | IgA nephropathy |
| IgA, secretory | The principle ig found in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. It is composed of two to four molecules of 7s IgA and one molecule each of j chain and secretory component (sc), also called secretory piece. Molecular weight appr. 400,000. (12 Dec 1998) |
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| secretory component of IgA | <immunology, protein> A polypeptide chain of about 60 kD that aids secretion of the IgA, a portion of the IgA receptor on the plasmalemma of the inner side of the epithelial cells lining the gut, which is proteolysed when the IgA receptor complex has travelled through the cell after receptor mediated endocytosis at the inner face, to the outer (luminal) face. (18 Nov 1997) |
|---|---|
| glomerulonephritis, IgA | Chronic form of glomerulonephritis characterised by recurring haematuria with only slight proteinuria and by deposits of IgA immunoglobulin in the mesangial areas of the renal glomeruli. It usually occurs in young males. (12 Dec 1998) |
| IgA | <immunology> Major class of immunoglobulin of external secretions in mammals, also found in serum and body fluids such as tears and saliva and in the respiratory, reproductive, urinary and gastrointestinal tracts. Immunoglobulin A protects the bodys mucosal surfaces from infection and in secretions, it is found as a dimer (400 kD) joined by a short J chain and linked to a secretory portion or transport piece. In serum found as a monomer (170 kD). Immunoglobulin A is the main mechanism for providing local immunity against infections in the gut or respiratory tract and may act by reducing the binding between an immunoglobulin A coated micro organism and a host epithelial cell. Present in human colostrum but not transferred across the placenta. Have heavy chains. (30 Mar 1998) |
| IgA deficiency | A dysgammaglobulinaemia characterised by a deficiency of IgA. (12 Dec 1998) |
| IgA nephropathy | <nephrology, pathology> This is a form of glomerulonephritis that results from the deposition of circulating IgA antibody in the kidney tissues. Inflammation of the glomerulus (glomerulonephritis) is the result. This condition may present as acute glomerulonephritis, chronic glomerulonephritis or rapidly progressive glomerulonephritis. Berger's is usually detected in an individual with one or two bouts of bloody urine (usually begins during or soon after a respiratory infection) and no other symptoms of renal disease. Only rarely, will Berger's disease permanently affect kidney function and progress to chronic renal failure. This renal disorder more commonly affects males in the 16-40 age group. Origin: Gr. Pathos = disease (27 Sep 1997) |
| IgA-specific serine endopeptidase | <enzyme> Extracellular microbial enzymes whose only substrate is human IgA of the iga1 subclass; cleave the immunoglobulin at a specific internal prolyl-threonyl peptide bond in the heavy chain to yield intact faba and fca fragments; consider also EC 3.4.24.13 Registry number: EC 3.4.21.72 Synonym: immunoglobulin a(1) protease, iga1 protease, immunoglobulin a1 protease, IgA protease (26 Jun 1999) |
| linear IgA bullous disease in children | A rare self-limiting bullous disease, chiefly of the trunk, perioral, and pelvic areas, with onset in the first decade, successively less severe recurrences, and total remission at adolescence; linear epidermal basement membrane zone deposit of IgA is found in involved and in normal skin. Synonym: linear IgA bullous disease in children. (05 Mar 2000) |
| androgen-dependent secretory protease | <enzyme> Glycoprotein from dog prostate; hydrolyzes arginine and lysine-containing amide and ester protease substrates Registry number: EC 3.4.99.- Synonym: ads-protease (26 Jun 1999) |
| secretory | <physiology> Secreting; performing, or connected with, the office secretion; secernent; as, secretory vessels, nerves. A secretory vessel; a secernent. Origin: Cf. F. Secretoire. See Secrete. Source: Websters Dictionary (01 Mar 1998) |
| secretory canaliculus | See: intercellular canaliculus, intracellular canaliculus. (05 Mar 2000) |
| secretory carcinoma | <tumour> Carcinoma of the breast with pale-staining cells showing prominent secretory activity, as seen in pregnancy and lactation, but found mostly in children. Synonym: juvenile carcinoma. (05 Mar 2000) |
| secretory cell | <biology> Cells specialised for secretion, usually epithelial. Those that secrete proteins characteristically have well developed rough endoplasmic reticulum, whereas conspicuous smooth endoplasmic reticulum is typical of cells that secrete lipid or lipid derived products (e.g. Steroids). (18 Nov 1997) |
| secretory component | <physiology> A glycoprotein found in a variety of external secretions (tears, bile, colostrum) usually complexed to secreted polymeric immunoglobulins (IgA or, less frequently IgM). It is derived, by proteolytic cleavage, from the polymeric immunoglobulin receptor (receptors, polymeric immunoglobulin) and probably functions to protect the immunoglobulins from proteolysis in the secretions. (12 Dec 1998) |
| secretory cyst | A cyst resulting from some obstruction to the excretory duct of a gland. Synonym: distention cyst, secretory cyst. (05 Mar 2000) |
| secretory duct | A type of intralobular duct found in some salivary glands that modifies the secretory product; it derives its name from extensive infolding of the basal membrane. Synonym: salivary duct, secretory duct. (05 Mar 2000) |
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