| hyoscyamine | <chemical> A chemical with the formula C17H23O3N which is a white powder at room temperature and which melts at 108.5 degrees C. It comes from plants such as henbane and belladona. Hyoscyamine is used medically as the levorotatory isomer of racemic atropine and as an anticholinergic alkaloid. (08 Mar 2000) |
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| hyoscyamine (6S)-dioxygenase | <enzyme> A 2-oxoglutarate-dependent dioxygenase that catalyses hydroxylation of l-hyoscyamine to 6beta-hydroxyhyoscyamine in biosynthetic pathway to scopolamine; requires fe2+ Registry number: EC 1.14.11.11 Synonym: hyoscyamine 6beta-hydroxylase, hyoscyamine 6 beta-hydroxylase (26 Jun 1999) |
| hyoscyamine sulfate | <drug> An antispasmodic, hypnotic, and sedative, also used in parkinsonism to relieve tremor, rigidity, and excessive salivation. (05 Mar 2000) |
| dl-hyoscyamine | <drug> A toxic alkaloid extracted from belladonna and other members of thenightshade family, it is typically used to dilate the eye and to stopmuscular spasms. Pharmacologic action: Parasympatholytic. Competitive blockade of acetylcholine at muscarinic receptors. Increases sinus node automaticity and AV conduction. Uses: Treat bradycardia, asystole, and AV block Dose: 0.5 - 1.0 mg for bradycardia every 3 - 5 min to a total dose of 0.04 mg/kg. Doses smaller than 0.5 mg can cause a paradoxical bradycardia due to sympathomimetic effects Typically 3 mg is adequate to completely block vagal effects Atropine is well absorbed via endotracheal route - administer 1-2 mg diluted in 10 mL sterile water or normal saline. Potential complications: 1. Tachyarrhythmias 2. Exacerbation of myocardial ischemia 3. Low dose may cause paradoxical bradycardia 4. Dry mouth, urinary retention, flushed and hot skin 5. Crosses blood-brain barrier which can cause delirium Note: The denervated heart will not respond to atropine. (15 Mar 2000) |
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| hyoscyamine |
a poisonous crystalline alkaloid (isometric with atropine but more potent); used to treat excess motility of the gastrointestinal tract
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| Hyoscyamine | a poisonous crystalline alkaloid (isometric with atropine but more potent) |
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