| ¿µ¹® | cell-mediated immunity | ÇÑ±Û | ¼¼Æ÷¸Å°³¸é¿ª |
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| ¿µ¹® | gene | ÇÑ±Û | À¯ÀüÀÚ |
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| ¼³¸í | À¯ÀüÀÚ´Â ±æ°Ô ¶ì¸¦ Çü¼ºÇÑ DNAºÐÀÚÀÇ ÀϺκÐÀ¸·Î ÇÑ °¡Áö ¹°ÁúÀ» ¸¸µå´Âµ¥ ÇÊ¿äÇÑ ¸ðµç Á¤º¸¸¦ °®Ãá ±â´ÉÀûÀÎ ´ÜÀ§ÀÌ´Ù. ¿¹¸¦ µé¾î Àν¶¸°À̶ó´Â ¹°ÁúÀÇ À¯ÀüÀÚ¶ó°í ÇÏ¸é »ç¶÷ÀÇ ¼¼Æ÷³»¿¡ ÀÖ´Â ±ä DNA ºÐÀÚ Áß¿¡¼ Àν¶¸°À̶ó´Â ¹°ÁúÀ» ¸¸µå´Âµ¥ ÇÊ¿äÇÑ ¸ðµç Á¤º¸¸¦ °¡Áö°í ÀÖ´Â ÇÑ ºÎºÐÀ» °¡¸®Å°´Â ¸»ÀÌ´Ù. °íÀüÀûÀÎ »ý¹°Çп¡¼´Â À¯ÀüÀÚ°¡ Ç¥ÇöÇüÀ» °áÁ¤Çϰųª ÁöÁ¤ÇÏ´Â ¿°»öüÀÇ ÀϺκÐÀ̶ó°í Á¤ÀǵǾúÁö¸¸, ¿À´Ã³¯¿¡´Â À¯ÀüÀÚ¿¡ ´ëÇØ¼ ºÐÀÚÀû Á¤Àǰ¡ Á¦¾ÈµÇ°í ÀÖÀ¸¸ç ±× Á¤ÀÇ´Â ÇϳªÀÇ À¯ÀüÀÚ´Â ÇϳªÀÇ È¿¼Ò¸¦ °áÁ¤ ¶Ç´Â ¾ÏÈ£ÈÇÏ´Â À¯Àü¹°ÁúÀÇ ÀϺκÐÀ̶ó´Â °³³äÀ¸·Î À̰ÍÀÌ À̸¥¹Ù 1°³ÀÇ À¯ÀüÀÚ 1°³ È¿¼Ò°¡¼³(one gene-one enzyme hypothesis)ÀÌ´Ù. Áï 1°³ÀÇ À¯ÀüÀÚ´Â 1°³ÀÇ È¿¼Ò¸¦ Á¦ÀÛÇϴµ¥ ÇÊ¿äÇÑ À¯ÀüÁ¤º¸¸¦ °¡Áø´Ù´Â °ÍÀÌ´Ù. ÇöÀç ÀÌ °¡¼³ÀÌ ¹Þ¾Æµé¿©Áö°í ÀÖ´Ù. |
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| ¿µ¹® | gene therapy | ÇÑ±Û | À¯ÀüÀÚ¿ä¹ý |
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| ¼³¸í | À¯Àüº´À» Ä¡·áÇÒ ¸ñÀûÀ¸·Î, Á¤»óÀûÀ¸·Î ±â´ÉÇÏ´Â ´ÜÀÏÀ¯ÀüÀÚ È¤Àº º¹¼öÀ¯ÀüÀÚ¸¦ ¾î¶² ±â¿ø¿¡¼ ¾ò¾î³»¾î »ý¼¼Æ÷¿¡ µµÀÔÇÏ´Â °Í. À¯Àü¹°ÁúÀº À¯ÀüÀÚ»ðÀÔ Á¶ÀÛ¿¡ ÀÇÇØ ¼ö¿ë¼¼Æ÷¿¡·Î µµÀԵȴÙ. Áï, À¯ÀüÀÚ¸¦ ³¢¿ö ³ÖÀº »õ·Î¿î ¼¼Æ÷¸¦ »ç¿ëÇÏ´Â Ä¡·á·Î¼ 1980³â ¹Ì±¹ÀÇ ÇÐÀÚ°¡ ÁöÁßÇØºóÇ÷ȯÀÚ¿¡°Ô °ÇàÇÏ¿© ºñÆÇÀ» ¹Þ¾ÒÁö¸¸, ¹Ì±¹ ±¹¸³º¸°Ç¿¬±¸¼Ò´Â 1990³â 9¿ù ¾Æµ¥³ë½Å µ¥¾Æ¹Ì³ª¾ÆÁ¦(adenosine deaminase, ADA) °áÇÌÁõ ȯÀÚÀÇ ¸²ÇÁ±¸¿¡ ADA À¯ÀüÀÚ¸¦ ³¢¿ö ³Ö´Â Ä¡·á¸¦ ½ÃÀÛÇÑ ÀÌ·¡ ÇöÀç´Â ¾ÏÀ» Æ÷ÇÔÇÑ ¸¹Àº Áúº´µéÀ» Ä¡·áÇÏ´Â ¸ñÀûÀ¸·Î ¾²ÀδÙ. |
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| CMGT | chromosome-mediated gene transfer |
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| DMGT | deoxyribonucleic acid-mediated gene transfer |
| CML | carboxymethyl lysine; cell-mediated lymphocytotoxicity; cell-mediated lympholysis; central motor lat... |
| HFR | high-frequency recombination |
| Hfr | heart frequency; high frequency |
| CMGT | Chromosome mediated gene transfer |
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| MMCT | Microcell-mediated chromosome transfer |
| ADCC | Antibody Dependent Cell-Mediated Cytotoxicity |
| ADCC | Antibody-dependent cell-mediated cytolysis |
| CML | Cell Mediated Lympholysis |
| HFR strain | A strain, or clone, in which a conjugative plasmid (such as an F'), integrated in the bacterial genome, is instrumental in the transfer (along with plasmid DNA) of integrated bacterial DNA in a sequential manner to a suitable recipient. Origin: high freguency of recombination (05 Mar 2000) |
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| receptor mediated endocytosis | Endocytosis of molecules by means of a specific receptor protein that normally resides in a coated pit, but may enter this structure after complex formation occurs. The structure then forms a coated vesicle that delivers its contents to the endosome whence it may enter the cytoplasm or the lysosomal compartment. Many bacterial toxins and viruses enter cells by this route. (18 Nov 1997) |
| cell-mediated immunity | <immunology> Immune response that involves effector T lymphocytes and not the production of humoral antibody. Responsible for allograft rejection, delayed hypersensitivity and in defence against viral infection and intracellular protozoan parasites. (26 Mar 1998) |
| cell-mediated reaction | Immunological reaction of the delayed type, involving chiefly T lymphocytes, important in host defense against infection, in autoimmune diseases, and in transplant rejection. See: skin test. (05 Mar 2000) |
| gene transfer | <molecular biology> General tem for the insertion of foreign genes into a cell or organism. Synonymous with transfection. (18 Nov 1997) |
| adoptive transfer | Form of passive immunization where previously sensitised immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (immunotherapy, adoptive). (12 Dec 1998) |
| gamete intra-fallopian transfer | <gynaecology> Gamete intra-fallopian transfer is a technique that involves combining eggs and sperm outside of the body and immediately placing them into the fallopian tubes to achieve fertilization. A technique that came into use in the mid-1980's for assisted conception in infertile women with normal fallopian tubes. The protocol consists of hormonal stimulation of the ovaries, followed by laparoscopic follicular aspiration of oocytes, and then the transfer of sperm and oocytes by catheterization into the fallopian tubes. Acronym: GIFT (12 Dec 1998) |
| gel transfer | Any lab technique used to transfer substances which had been separated using gel electrophoresis from the gel to a membrane for further processing or analysis. For example: any type of blotting. (09 Oct 1997) |
| cavernous transfer of portal vein | <anatomy, vein> Replacement of the portal vein by a number of collateral channels, a consequence of thrombosis. (05 Mar 2000) |
| patient transfer | Interfacility or intrahospital transfer of patients. Intrahospital transfer is usually to obtain a specific kind of care and interfacility transfer is usually for economic reasons as well as type of care provided. (12 Dec 1998) |
| resistance-transfer factor | The transfer gene of the resistance plasmid. (05 Mar 2000) |
| resonance energy transfer | <technique> Transfer of energy from one fluorochrome to another. The emission wavelength of the fluorochrome excited by the incident light must approximately match the excitation wavelength of the second fluorochrome. If light at the second emission wavelength is detected, it implies that the two fluorochromes were physically within a few nanometres. Used as a technique to probe protein or cell interactions. (25 Jun 1999) |
| charge transfer | A complex between two organic molecules in which an electron from one (the donor) is transferred to the other (the acceptor), becoming generally distributed throughout the latter; subsequent transfer of a hydrogen atom completes the reduction of the acceptor; such complex's are generally highly coloured and may be so observed, a network of hydrogen bridges at the catalytic centre of certain proteases. Synonym: charge transfer system. (05 Mar 2000) |
| charge transfer complex | A complex between two organic molecules in which an electron from one (the donor) is transferred to the other (the acceptor), becoming generally distributed throughout the latter; subsequent transfer of a hydrogen atom completes the reduction of the acceptor; such complex's are generally highly coloured and may be so observed, a network of hydrogen bridges at the catalytic centre of certain proteases. Synonym: charge transfer system. (05 Mar 2000) |
| charge transfer system | A complex between two organic molecules in which an electron from one (the donor) is transferred to the other (the acceptor), becoming generally distributed throughout the latter; subsequent transfer of a hydrogen atom completes the reduction of the acceptor; such complex's are generally highly coloured and may be so observed, a network of hydrogen bridges at the catalytic centre of certain proteases. Synonym: charge transfer system. (05 Mar 2000) |
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