| TRS | testicular regression syndrome; total reducing sugars; tubuloreticular structure |
|---|---|
| SSC | single-strand conformational [analysis]; sister strand crossover; somatosensory cortex; standard sal... |
| SSCP | single-stranded conformational polymorphism |
| cAMP | cyclic Adenosine Mono-Phosphate |
| cGMP | cyclic Guanosine Mono-Phosphate |
| cyclic AMP | 3',5'-cyclic adenosine monophosphate |
|---|---|
| cyclic AMP | 3',5'-cyclic monophosphate |
| cyclic GMP | 3',5'-cyclic monophosphate |
| cyclic AMP | Cyclic 3',5' adenosine monophosphate |
| cyclic GMP | Cyclic guanosine 3',5' monophosphate |
| Haworth conformational formula | <biochemistry> Of cyclic sugars, for the pyranoses, these depict those shapes (conformations) on which none, one, or two ring-atoms lie outside the plane of the ring. If there are two such atoms para to each other, they can lie 1) on opposite sides of the plane (trans), giving chair forms, or 2) on the same side of the plane (cis), giving boat forms. For beta-d-ribopyranose, the two chair forms (4C1 and 1C4) are depicted. Similarly, there are six boat conformations. If the two (trans) exoplanar atoms are meta to each other, the conformation is a skew form; if the two atoms are ortho to each other, the conformation is a half-chair form. For the furanoses, the envelope conformations have one ring-atom exoplanar. If there are three adjacent, coplanar ring-atoms (the two exoplanar ring-atoms on opposite sides of the plane), the conformations are twist forms. (05 Mar 2000) |
|---|---|
| Haworth perspective formula | <biochemistry> Of cyclic sugars, perspective representations of furanose or pyranose structures as pentagons or hexagons, respectively, with the connecting bonds so shaded as to make them appear as though the plane of the ring is at an angle of 30 |
| Haworth, Sir Walter Norman | <person> British chemist and Nobel laureate, 1883-1950. See: Haworth conformational formulas of cyclic sugars, Haworth perspective formulas of cyclic sugars. (05 Mar 2000) |
| conformational change | <cell biology> Alteration in the shape usually the tertiary structure of a protein as a result of alteration in the environment pH, temperature, ionic strength) or the binding of a ligand (to a receptor) or binding of substrate (to an enzyme). (18 Nov 1997) |
| conformational map | A graphical representation in which the dihedral angle of rotation about the alpha-carbon to carbonyl-carbon bond in polypeptides is plotted against the dihedral angle of rotation about the alpha-carbon to nitrogen bond. Synonym: conformational map. (05 Mar 2000) |
| polymorphism, single-stranded conformational | Variation occurring within a species in the conformation of denatured DNA fragments. These single-stranded DNA fragments are allowed to partially renature in a way that prevents the formation of double-stranded DNA. The fragments are run on polyacrylamide gels under various conditions to detect subtle changes in migration due to altered secondary structure. The resulting bands will align themselves if the fragments are the same, but will misalign if any point mutations are present. Sscps have been used in detecting mutations in various genes, such as oncogenes, tumour suppressor genes, and genes responsible for genetic diseases. (12 Dec 1998) |
| single stranded conformational polymorphism | Technique for detecting point mutations in genes by amplifying a region of genomic DNA (using asymmetric PCR) and running the resulting product on a high quality gel. Single base substitutions can alter the secondary structure of the fragment in the gel, producing a visible shift in its mobility. (18 Nov 1997) |
| adenosine diphosphate sugars | Esters formed between the aldehydic carbon of sugars and the terminal phosphate of adenosine diphosphate. (12 Dec 1998) |
| amino sugars | Sugar's in which a hydroxyl group has been replaced with an amino group; e.g., d-glucosamine. (05 Mar 2000) |
| guanosine diphosphate sugars | Esters formed between the aldehydic carbon of sugars and the terminal phosphate of guanosine diphosphate. (12 Dec 1998) |
| polyisoprenyl phosphate sugars | Compounds functioning as activated glycosyl carriers in the biosynthesis of glycoproteins and glycophospholipids. They include the polyisoprenyl pyrophosphates. (12 Dec 1998) |
| sugars | Those carbohydrates (saccharides) having the general composition (CH2O)n and simple derivatives thereof. Although the simple monomeric sugars (glycoses) are often written as polyhydroxy aldehydes or ketones, e.g., HOCH2-(CHOH)4-CHO for aldohexoses (e.g., glucose) or HOCH2-(CHOH)3-CO-CH2OH for 2-ketoses (e.g., fructose), cyclization can give rise to varied structures as described below. Sugars are generally identifiable by the ending -ose or, if in combination with a nonsugar (aglycon), -oside or -osyl. Sugars especially d-glucose, are the chief source of energy, by oxidation, in nature, and they and their derivatives (e.g., d-glucosamine, d-glucuronic acid), in polymeric form, are major constituents of mucoproteins, bacterial cell walls, and plant structural material (e.g., cellulose). Sugars are often found in combination with steroids (steroid glycosides) and other aglycons. (05 Mar 2000) |
| nucleoside-diphosphate sugars | Nucleoside diphosphates linked through the 5'-diphosphoric group with simple or complex carbohydrates; e.g., GDP-mannose, UDP-glucose (UDPG), dTDP-glucosamine. (05 Mar 2000) |
| dTDP-sugars | Sugars or sugar derivatives bonded to dTDP. (05 Mar 2000) |
| adenosine 3',5'-cyclic monophosphate | An activator of phosphorylase kinase and an effector of other enzymes, formed in muscle from ATP by adenylate cyclase and broken down to 5'-AMP by a phosphodiesterase; sometimes referred to as the "second messenger." A related compound (2',3') is also known. Synonym: cyclic adenylic acid, cyclic AMP, cyclic phosphate. Acronym: cAMP (05 Mar 2000) |
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