| HTLF | human T-cell leukemia virus enhancer factor |
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| TEF | thermic effect of food; thyrotroph embryonic factor; tracheoesophageal fistula; transcriptional enha... |
| TFE | polytetrafluoroethylene; transcription factor for immunoglobulin heavy chain enhancer |
| HIV | Human Immunodeficiency Virus |
| CD4 | HIV helper cell count |
| HIV AN | HIV associated nephropathy |
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| HIV- | HIV negative |
| HIV+ | HIV positive |
| HIV Pr | HIV protease |
| HIV- | HIV sero-negative |
| HIV enhancer | Cis-acting regulatory sequences in the HIV long terminal repeat (ltr) which play a major role in induction or augmentation of HIV gene expression in response to environmental stimuli such as mitogens, phorbol esters, or other viruses. The HIV enhancer is the binding site for many cellular transcription factors including the nuclear factor nf-kappa b. (12 Dec 1998) |
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| enhancer element | <molecular biology> A DNA sequence, present in the genomes of higher eukaryotes and of various animal viruses, which can increase the transcription of genes into messenger RNA. These control element frequently found 5' to the start site of a gene, when bound by a specific transcription factor, enhance the levels of expression of the gene, but are not sufficient alone to cause expression. Distinguished from a promoter, that is alone sufficient to cause expression of the gene when bound, in practice, the two terms merge. Enhancers usually can function in either orientation and at various distances from a promoter. Compare: promoter. (03 Jul 1999) |
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| enhancer sequence | <molecular biology> A nucleotide sequence, located as many as several thousand base pairs away in either direction from the target gene, which enhances transcription of that gene. (14 Nov 1997) |
| enhancer trap | <molecular biology, technique> Technique for mapping gene expression patterns, classically in Drosophila. A transposon element carrying a reporter gene (usually _ galactosidase), linked to a very weak promoter, is induced to jump within the genome. If the P element re inserts within the sphere of influence of promoters and enhancers of some (random) gene, then reporter gene is also expressed in a similar tissue specific manner. Usually, many lines of flies carrying such random insertions are studied, if a line shows interesting patterns of expression, it can be possible to clone the gene of interest. (18 Nov 1997) |
| anti-HIV agents | Agents used to treat aids and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with aids. (12 Dec 1998) |
| receptors, HIV | Cellular receptors that bind the human immunodeficiency virus that causes aids. Included are CD4 antigens, found on t4 lymphocytes, and monocytes/macrophages, which bind to the HIV envelope protein gp120. (12 Dec 1998) |
| chronic symptomatic HIV infection | This refers to an HIV infection that is characterised by signs and symptoms of HIV that are not life-threatening. Examples include oral thrush, gingivitis, seborrheic dermatitis, molluscum contangiosum, fevers, fatigue, lymph node swelling, malaise and weight loss. This stage can be a signal for the conversion from asymptomatic HIV disease to HIV disease (moe pronouced symptoms include joint pains). AIDS is diagnosed after HIV disease has started to manifest life-threatening oppotunistic infections (for example pneumocystis, cryptosporidium, toxoplasmosis, etc). (27 Sep 1997) |
| middle stage HIV disease | <disease> This refers to an HIV infection that is characterised by signs and symptoms of HIV that are not life-threatening. Examples include oral thrush, gingivitis, seborrheic dermatitis, molluscum contangiosum, fevers, fatigue, lymph node swelling, malaise and weight loss. This stage can be a signal for the conversion from asymptomatic HIV disease to HIV disease (moe pronouced symptoms include joint pains). AIDS is diagnosed after HIV disease has started to manifest life-threatening oppotunistic infections (for example pneumocystis, cryptosporidium, toxoplasmosis, etc). (27 Sep 1997) |
| primary HIV infection | <infectious disease> The flu-like syndrome that oc immediately after a person contracts HIV. This mini infection precedes seroconversion and is characterised fever, sore throat, headache, skin rash and swollen glands. (06 Mar 1998) |
| HIV | <virology> A type of retrovirus (human immunodeficiency virus) that is responsible for the fatal illness acquired immunodeficiency syndrome. Two strains have been identified. Type 1: the retrovirus recognised as the agent that induces AIDS. Type 2: a virus closely related to HIV-1 that also leads to immune suppression. HIV-2 is not as virulent as HIV-1 and is epidemic only in West Africa. Acronym: HIV (11 Nov 1997) |
| HIV-1 | The type species of lentivirus and widely recognised as the aetiologic agent of acquired immunodeficiency syndrome (aids). It is characterised by its cytopathic effect and affinity for the t4-lymphocyte. (12 Dec 1998) |
| HIV-1 reverse transcriptase | <enzyme> HIV-1 enzyme responsible for the synthesis of DNA from genomic RNA of the virus. It is encoded by the pol gene of HIV-1. Registry number: EC 2.7.7.- (12 Dec 1998) |
| HIV-2 | An HIV species related to HIV-1 but carrying different antigenic components and with differing nucleic acid composition. It shares serologic reactivity and sequence homology with the simian lentivirus siv and infects only t4-lymphocytes expressing the CD4 phenotypic marker. (12 Dec 1998) |
| HIV-2 protease | <enzyme> Processes hiv-1pr53(gag) and analogous junction peptides in vitro; less than 60% amino acid identity to hiv-1 protease Registry number: EC 3.4.23.- Synonym: hiv2 protease (26 Jun 1999) |
| HIV-2 reverse transcriptase | <enzyme> Responsible for synthesis of double-stranded DNA from the genomic RNA of the virus; has rnase h and DNA-dependent DNA polymerase activities; was indexed as reverse transcriptase (87-91) Registry number: EC 2.7.7.- (26 Jun 1999) |
| HIV antibodies | Antibodies reactive with human immunodeficiency virus (HIV, previously called HTLV-III/lav) antigens of aids. This includes HIV-1 antibodies and HIV-2 antibodies. (12 Dec 1998) |
Synonyms : HIV-1 Enhancer, NF-kB Binding Site, HIV, NF-kB-Binding Site, HIV, Enhancer, HIV, Enhancer, HIV-1, Enhancers, HIV, Enhancers, HIV-1, HIV 1 Enhancer, HIV Enhancers, HIV NF kappa B Binding Site, HIV NF-kB-Binding Site, HIV NF-kB-Binding Sites, HIV-1 Enhancers
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