| 영문 | gene | 한글 | 유전자 |
|---|---|---|---|
| 설명 | 유전자는 길게 띠를 형성한 DNA분자의 일부분으로 한 가지 물질을 만드는데 필요한 모든 정보를 갖춘 기능적인 단위이다. 예를 들어 인슐린이라는 물질의 유전자라고 하면 사람의 세포내에 있는 긴 DNA 분자 중에서 인슐린이라는 물질을 만드는데 필요한 모든 정보를 가지고 있는 한 부분을 가리키는 말이다. 고전적인 생물학에서는 유전자가 표현형을 결정하거나 지정하는 염색체의 일부분이라고 정의되었지만, 오늘날에는 유전자에 대해서 분자적 정의가 제안되고 있으며 그 정의는 하나의 유전자는 하나의 효소를 결정 또는 암호화하는 유전물질의 일부분이라는 개념으로 이것이 이른바 1개의 유전자 1개 효소가설(one gene-one enzyme hypothesis)이다. 즉 1개의 유전자는 1개의 효소를 제작하는데 필요한 유전정보를 가진다는 것이다. 현재 이 가설이 받아들여지고 있다. |
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| 영문 | gene therapy | 한글 | 유전자요법 |
|---|---|---|---|
| 설명 | 유전병을 치료할 목적으로, 정상적으로 기능하는 단일유전자 혹은 복수유전자를 어떤 기원에서 얻어내어 생세포에 도입하는 것. 유전물질은 유전자삽입 조작에 의해 수용세포에로 도입된다. 즉, 유전자를 끼워 넣은 새로운 세포를 사용하는 치료로서 1980년 미국의 학자가 지중해빈혈환자에게 강행하여 비판을 받았지만, 미국 국립보건연구소는 1990년 9월 아데노신 데아미나아제(adenosine deaminase, ADA) 결핍증 환자의 림프구에 ADA 유전자를 끼워 넣는 치료를 시작한 이래 현재는 암을 포함한 많은 질병들을 치료하는 목적으로 쓰인다. |
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| Gm | an allotype marker on the heavy chains of immunoglobins |
|---|---|
| mar | margin; marker [chromosome] |
| mar(X) | marker X [chromosome] |
| MOMX | macroorchidism-marker X chromosome [syndrome] |
| OMP | olfactory marker protein; ornithine monophosphate; outer membrane protein |
| MAS | Marker Assisted Selection |
|---|---|
| OMP | Olfactory Marker Protein |
| SMP 30 | Senescence marker protein 30 |
| SMC | Supernumerary Marker Chromosome |
| Lin | lineage marker |
| marker gene | Gene that confers some readily detectable phenotype on cells carrying the gene, either in culture or in transgenic or chimeric organisms. Gene could be an enzymic reporter gene, a selectable marker conferring antibiotic resistance or a cell membrane protein with a characteristic epitope. (18 Nov 1997) |
|---|---|
| allotypic marker | Synonym: allotype. (05 Mar 2000) |
| genetic marker | A gene which has an easily identifiable phenotype so that one can tell apart cells or individuals which have the gene and those which do not have it. Such a gene can also be used as a probe to mark cell nuclei or chromosomes so that they can easily be isolated or identified from other nuclei or chromosomes later. (09 Oct 1997) |
| marker | An identifiable physical location on a chromosome (for example, restriction enzyme cuttingsite, gene) whose inheritance can bemonitored. Markers can beexpressed regions of DNA (genes) or some segment of DNA with no knowncoding function but whose pattern of inheritance can be determined. See: restriction fragment length polymorphism. (09 Oct 1997) |
| marker chromosome | An abnormal chromosome that is distinctive in appearance but not fully identified. For example, the fragile x chromosome was once called the marker x. (12 Dec 1998) |
| marker enzyme | <enzyme> An enzyme that is used to identify a specific cell type, cell organelle, or cell component. (05 Mar 2000) |
| marker locus | A locus on a chromosome or in a stretch of DNA that can be identified (e.g., a restriction fragment length polymorphism) and can serve in linkage analysis and in the isolation of a disease gene. See: linkage marker. (05 Mar 2000) |
| marker, object | <microscopy> A small abrasive stylus, set in a rotating holder mounted on the lower end of the drawtube. The desired part of the specimen is placed in the centre of the field, and the abrasive point is pressed against the slide or cover, and rotated. It describes a tiny circle around the desired object field. (05 Aug 1998) |
| marker trait | A trait that may be of little importance in itself but which by association, linkage, or other means facilitates the detection, anticipation, or understanding of a disease or (for genetic diseases) the localization of the causative gene on the karyotype. (05 Mar 2000) |
| cell marker | <cell biology> Biochemical or genetic characteristics which distinguish and discriminate between different cell types. (26 Mar 1998) |
| cell surface marker | <cell biology> Any molecule characteristic of the plasma membrane of a cell or in some cases of a specific cell type. 5' nucleotidase and Na/K ATPase are often used as plasma membrane markers. (26 Mar 1998) |
| selectable marker | <molecular biology> A gene whose expression allows one to identify cells that have been transforrned or transfected with a vector containing the marker gene. (09 Oct 1997) |
| hypoxanthine-guanine phosphoribosyl tranferase marker | The gene which codes for the enzyme hypoxanthine-guanine phosphoribosyl transferase. It is a selectable marker because cells which have a defective version of this gene are resistant to poisoning by toxic purine derivatives which result from the metabolic pathway that the HGPRT enzyme catalyses. (The purine derivatives are toxic because they incorporate into DNA as a result of the HGPRT enzyme's actions). Because the defective gene cannot produce the enzyme, no toxic purine derivatives are produced, the gene can therefore be selected for. (09 Oct 1997) |
| surrogate marker | <biology> A laboratory measurement of biological activity within the body that indirectly indicates the effect of treatment on disease state. CD4 cell counts and viral load are examples of surrogate markers in HIV infection. (19 Jan 1998) |
| oncofetal marker | A tumour marker produced by tumour tissue and by foetal tissue of the same type as the tumour, but not by normal adult tissue from which the tumour arises. (05 Mar 2000) |
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|