| BFL | bird fancier's lung; Borjeson-Forssman-Lehman [syndrome] |
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| BFLS | Borjeson-Forssman-Lehmann syndrome |
| Forssman hapten | A glycolipid from mammalian organs. Compare: Forssman antibody, Forssman antigen. (05 Mar 2000) |
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| conjugated hapten | A hapten that may cause the production of antibodies when it has been covalently linked to protein. Synonym: conjugated antigen. (05 Mar 2000) |
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| half-hapten | A substance that elicits an antigen-antibody reaction, but no precipitation. (05 Mar 2000) |
| hapten | <immunology, molecular biology> Could be considered an isolated epitope: although a hapten (by definition) has an antibody directed against it, the hapten alone will not induce an immune response if injected into an animal, it must be conjugated to a carrier (usually a protein). The hapten constitutes a single antigenic determinant, perhaps the best known example is dinitro phenol (DNP) that can be conjugated to BSA and against which antiDNP antibodies are produced (antibodies to the BSA can be adsorbed out). Because the hapten is monovalent, immune complex formation will be blocked if the soluble hapten is present as well as the hapten carrier conjugate (assuming there is more than one hapten per carrier then an immune precipitate can be formed). Competitive inhibition by the soluble small molecule is sometimes referred to as haptenic inhibition and this term has carried over into lectin mediated haemagglutination where monosaccharides are added to try to block haemagglutination: the blocking sugar defines the specificity of the lectin. (18 Nov 1997) |
| hapten inhibition of precipitation | Inhibition of precipitation that occurs when the precipitin has combined with hapten of the same specificity as the subsequently added antigen. (05 Mar 2000) |
| Borjeson-Forssman-Lehmann syndrome | <syndrome> A condition characterised by mental deficiency, epilepsy, hypogonadism, hypometabolism, obesity, and narrow palpebral fissures; X-linked recessive inheritance. (05 Mar 2000) |
| Forssman antibody | A heterogenetic antibody specific for the Forssman group of heterogenetic antigens. Synonym: heterophil antibody, heterophile antibody. (05 Mar 2000) |
| Forssman antigen | A glycolipid heterophil antigen present on tissue cells of many species. It was first described for sheep red cells and is not present on human, rabbit, rat, porcine or bovine cells. (18 Nov 1997) |
| Forssman antigen-antibody reaction | The combination of Forssman antibody with heterogenetic antigen of the Forssman type, as in the agglutination of sheep erythrocytes (which contain Forssman antigen) by serum from a person with infectious mononucleosis which contains Forssman antibody. Synonym: Forssman reaction. (05 Mar 2000) |
| Forssman, Hans | <person> Swedish physician, *1912. See: Borjeson-Forssman-Lehmann syndrome. (05 Mar 2000) |
| Forssman, John | <person> Swedish bacteriologist and pathologist, 1868-1947. See: Forssman antibody, Forssman antigen, Forssman reaction, Forssman antigen-antibody reaction. (05 Mar 2000) |
| Forssman reaction | The combination of Forssman antibody with heterogenetic antigen of the Forssman type, as in the agglutination of sheep erythrocytes (which contain Forssman antigen) by serum from a person with infectious mononucleosis which contains Forssman antibody. Synonym: Forssman reaction. (05 Mar 2000) |
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