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FAS fatty acid synthetase; Federation of American Scientists; fetal alcohol syndrome
CLD chloride diarrhea; chronic liver disease; chronic lung disease; congenital limb deficiency; crystal ...
MLC minimum lethal concentration; mixed leukocyte culture; mixed ligand chelate; mixed lymphocyte concen...
MLCT metal-to-ligand charge transfer
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FAS-L FAS/FAS ligand
Fas-L Fas and Fas ligand
FAS-L FAS ligand
Fas-L Fas and its ligand
sFas-L soluble Fas ligand
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Fas-activated serine-threonine kinase <enzyme> Phosphorylates tia-1 during fas-mediated apoptosis; contains proline-rich sh3-binding domains; mw 60-63 kD; genbank x86779
Registry number: EC 2.7.10.-
Synonym: fast kinase
(26 Jun 1999)
Fas antigen <protein> Cell surface transmembrane protein (35 kD) that mediates apoptosis.
Has structural homology with TNF receptor and NGF receptor. May play a part in negative selection of autoreactive T-cells in the thymus.
(18 Nov 1997)
ambident ligand <chemistry> A ligand that can donate electrons through two or more atoms on their molecule.
(05 Feb 1998)
cyanocobalamin beta-ligand transferase <enzyme> Cytosolic enzyme utilizing fad, NADPH and reduced glutathione; forms glutathionylcobalamin from cyanocobalamin
Registry number: EC 2.5.1.-
Synonym: ccbl transferase
(26 Jun 1999)
ELAM-1 ligand fucosyltransferase <enzyme> Directs the expression of an elam-1 ligand; an alpha(1,3) fucosyltransferase
Registry number: EC 2.4.1.-
Synonym: elft protein, elft gene product
(26 Jun 1999)
ligand <chemistry, immunology> Any molecule that binds to another, in normal usage a soluble molecule such as a hormone or neurotransmitter, that binds to a receptor. The decision as to which is the ligand and which the receptor is often a little arbitrary when the broader sense of receptor is used (where there is no implication of transduction of signal). In these cases it is probably a good rule to consider the ligand to be the smaller of the two thus in a lectin sugar interaction, the sugar would be the ligand (even though it is attached to a much larger molecule, recognition is of the saccharide).
(18 Nov 1997)
ligand binding site The site on a protein's surface that binds a ligand; equivalent to the active site if the ligand is the substrate of an enzyme.
(05 Mar 2000)
ligand-gated channel A class of ion channel's whose ionic permeability is regulated by cell membrane receptors that respond to specific extracellular chemical signals.
(05 Mar 2000)
ligand gated ion channel A transmembrane ion channel whose permeability is increased by the binding of a specific ligand, typically a neurotransmitter at a chemical synapse. The permeability change is often drastic, such channels let through effectively no ions when shut, but allow passage at up to 10exp7 ions sexp 1 when a ligand is bound. Recently, the receptors for both acetylcholine and GABA have been found to share considerable sequence homology, implying that there may be a family of structurally related ligand gated ion channels.
(18 Nov 1997)
ligand induced endocytosis The formation of coated pits and then coated vesicles as a consequence of the interaction of ligand with receptors, which then interact with clathrin and associated proteins (coatomers) on the cytoplasmic face of the plasma membrane and come together to form a pit. Not all coated vesicle uptake of receptors requires receptor occupancy.
(18 Nov 1997)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 1 ÆäÀÌÁö: 1
  • Fas Ligand Protein - »õâ A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.
    Synonyms : CD178 Antigen, CD95 Antigen Ligand, CD95 Ligand, CD95L, Fas Ligand, Fas Ligand (FasL), FasL Protein, TNF Superfamily, Member 6, Antigen, CD178
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fas ligand A cell surface molecule belonging to the tumor necrosis factor family, which binds to its receptor Fas, inducing apoptosis. Various cells express Fas, whereas Fas ligand is expressed predominantly on natural killer cells and activated T-cells. Fas and Fas ligand are involved in antiviral immune responses, elimination of tumor cells, and regulation of lymphocyte development.
Ãâó: www.amfar.org/cgi-bin/iowa/bridge.html
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