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  • Donath-Landsteiner antibody
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  • Donath-Landsteiner autoantibody
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  • Donath-Landsteiner test
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  • donath-landsteiner antibody
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  • donath-landsteiner antibody
    Donath-Landsteiner antibody
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  • donath-landsteiner antibody
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  • Donath-Landsteiner test
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Donath-landsteiner <investigation> A serologic blood test used to detect antibody in serum in cases of suspected paroxysmal cold haemoglobinuria.
The antibody is directed toward the P-antigen complex which is located on the surface of red blood cells. In some way, cold temperatures trigger the antibody to bind to this site.
(15 Nov 1997)
Donath-Landsteiner cold autoantibody An autoantibody of the IgG class responsible for paroxysmal cold haemoglobinuria; it is adsorbed to red cells only at temperatures of 20°C or lower, causing the red cells to lyse in the presence of complement at higher temperatures; it has only slight agglutinating properties in spite of its marked lytic activity, and has a specificity within the blood group P; it is also occasionally present for short periods of time following measles and other infections, and formerly was frequently associated with syphilis.
Synonym: cold haemolysin.
(05 Mar 2000)
Donath-Landsteiner phenomenon The haemolysis which results in a sample of blood of a subject of paroxysmal haemoglobinuria when the sample is cooled to around 5°C and then warmed again.
(05 Mar 2000)
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Donath-Landsteiner antibody var. Donath-Landsteiner test. [Julius Donath, Austrian physician, 1870?1950; Karl L. Landsteiner, Austrian-born U.S. biologist, 1868?1943] A test for paroxysmal hemoglobinuria. Blood from the patient is
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Donath-Landsteiner a. an IgG antibody directed against the P blood group antigen; it binds to red cells at low temperatures and induces complement-mediated lysis on warming, and is responsible for hemolysis in paroxysmal cold hemoglobinuria.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
Donath-Landsteiner antibody, test see under antibody and test.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
Donath-Landsteiner t. (for paroxysmal cold hemoglobinuria): a test based on the fact that the blood of patients with this disease contains complement-dependent iso- and autohemolysin (Donath-Landsteiner antibody) which unites with red cells only at low temperatures (2° to 10°C), hemolysis occurring only after warming to 37°C.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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