| DNASE, DNAse, | DNase deoxyribonuclease |
|---|
| CAD | Caspase-activated DNase |
|---|---|
| DHS | DNAse I hypersensitive sites |
| DNase | Deoxyribonuclease |
| DNAse I | Deoxyribonuclease I |
| DNase II | Deoxyribonuclease II |
| anti-DNAse B | This is a serologic blood test used to detect antibodies against antideoxyribonuclease B (anti-DNAse B), an antigen that is produced by group A streptococci. This test is used to document a previous streptococcal infection in those who are suspected of having post-streptococcal disease (for example acute glomerulonephritis, rheumatic fever). A normal value is a negative assay. In adults this is less than 85 Todd units /ml. In school-age children this is less than 170 Todd units/ml. In pre-schoolers this is less than 60 Todd units/ml. Anywhere from 70 to 80% of people with rheumatic fever or post-streptococcal acute glomerulonephritis will have elevated anti-DNAse B levels. The test is performed on a venipuncture specimen. (27 Sep 1997) |
|---|---|
| DNAse | <enzyme> An endonuclease with preference for DNA. Pancreatic DNAse I yields di and oligo nucleotide 5_ phosphates, pancreatic DNAse II yields 3_ phosphates. In chromatin, the sensitivity of DNA to digestion by DNAse I depends on its state of organisation, transcriptionally active genes being much more sensitive than inactive genes. Acronym: DNAase (10 Nov 1998) |
| DNAse footprinting | <molecular biology> A lab technique used to find out which segments of a DNA molecule are protected by DNA-binding proteins from attack by endonuclease enzymes, which break down DNA into smaller fragments by cleaving its phosphodiester bonds. The technique does this with gel electrophoresis to find out which parts of the DNA have sites for proteins to attach to them, by comparing DNA which has been in the presence of DNA-binding proteins with DNA that is pure. (09 Oct 1997) |
| DNAse i | A type of endonuclease, or enzyme that breaks down DNA molecules at their phosphodiester bonds. It is found in large quantities in the pancreas. (09 Oct 1997) |
| DNAse i hypersensitivity site | <molecular biology> A site on a DNA molecule that is especially prone to being cut apart by the endonuclease enzyme DNase I, which breaks down DNA into smaller fragments by cleaving phosphodiester bonds. These sites tend to be near active genes, which are regularly transcribed. (09 Oct 1997) |
| DNAse i sensitivity | <molecular biology> The likelihood that a particular DNA segment will be attacked by the endonuclease enzyme DNase I, which breaks down DNA into smaller fragments by cleaving its phosphodiester bonds. DNA segments which contain active genes that are regularly transcribed are more prone to being cut apart by DNase I than inactivated genes, because the inactivated genes are generally within condensed regions of the chromosome, while the active genes are in more open configurations for easy access for transcription. (09 Oct 1997) |
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