| Tabs | tablets |
|---|---|
| MDIPT | Multicenter Diltiazem Postinfarction Trial |
| PREDICT | Prospective Randomized Evaluation of Diltiazem CD Trial |
| D | Diltiazem |
|---|---|
| DIL | Diltiazem |
| DTZ | Diltiazem |
| DZ | Diltiazem |
| diltiazem | <chemical> A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic. Pharmacological action: antihypertensive agents, calcium channel blockers, cardiovascular agents, teratogens, vasodilator agents. Direct, potent negative chronotrope with only mild negative inotropic effect; slows conduction in AV node; coronary vasodilation with less systemic vasodilation than verpamil. Chemical name: 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)- Uses: Control ventricular response with atrial fibrillation Dose: 0.25 mg/kg IV over 2 minutes May repeat at 0.35 mg/kg after 15 minutes. Maintenance infusion at 5 - 15 mg/hr. Potential complications: Less hypotension than with verapamil since less vasodilation and myocardial depression; bradycardia; may exacerbate AV block; synergistic interaction with beta blockers; relatively contraindicated with congestive heart failure. Note: Diltiazem can accelerate heart rate and decrease blood pressure, especially in patients with Wolff-Parkinson-White or wide-complex tachycardia. (15 Mar 2000) |
|---|---|
| diltiazem hydrochloride | 1,5-Benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-monohydrochloride, (+)-cis-;a calcium channel blocking agent used as a coronary vasodilator and antihypertensive. (05 Mar 2000) |
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