| BPTI | basic pancreatic trypsin inhibitor; basic polyvalent trypsin inhibitor; bovine pancreatic trypsin in... |
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| PI | first meiotic prophase; isoelectric point; pacing impulse; package insert; pancreatic insufficiency;... |
| AK | above knee; acetate kinase; adenosine kinase; adenylate kinase; artificial kidney |
| CK | calf kidney; casein kinase; chicken kidney; cholecystokinin; choline kinase; contralateral knee; cre... |
| TK | thymidine kinase; transketolase; triose-kinase; tyrosine kinase |
| Pak1 | P21-activated kinase 1 |
|---|---|
| PAK | p21-activated protein kinase |
| Ras | p21(ras |
| p21 | p21WAF/CIP1 |
| P21 | post-natal day 21 |
creatine kinase
| MAP kinase kinase kinase | <enzyme> From pc12 cells; reactivates map kinase kinase inactivated by protein phosphatase 2a by phosphorylation of serine residues; tak1 (tgf-beta-activated kinase 1) is a member of the mapkkk family; genbank ab006787 (mouse) Registry number: EC 2.7.10.- Synonym: mapkkk, tak1 mapkkk, ask1 (kinase), apoptosis signal-regulating kinase 1 (26 Jun 1999) |
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| p21(ras) farnesyl-protein transferase | <enzyme> Transfers the farnesyl moiety from farnesyl pyrophosphate to a cysteine in p21(ras) proteins; composed of an alpha and a beta subunit Registry number: EC 2.5.1.- Synonym: farnesyl-protein transferase p21(ras), ras p21 farnesyl-protein transferase, protein-cysteine farnesyltransferase, pc farnesyltransferase, protein farnesyltransferase, p21(ras) farnesyltransferase, farnesyl-protein transferase-alpha, farnesyl-protein transferase-beta, ft alpha, ft beta, caax farnesyltransferase, ftase enzyme (26 Jun 1999) |
| rhoA p21 geranylgeranyltransferase | <enzyme> Transfers geranylgeranyl group to cysteine residue fourth from the c-terminal group of rho p21; no particular requirement for c-terminal amino acid; see also ras protein geranylgeranyl transferase Registry number: EC 2.5.1.- Synonym: geranylgeranyltransferase rhoa p21 (26 Jun 1999) |
| proto-oncogene protein p21(ras) | Cellular protein encoded by the c-ras genes. The protein has GTPase activity and is involved in transmembrane signal transduction as a guanine nucleotide binding protein. Elevated levels of p21 c-ras have been associated with neoplasia. (12 Dec 1998) |
| oncogene protein p21(ras) | Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumours. (12 Dec 1998) |
| AMP-activated protein kinase kinase | <enzyme> An endogenous kinase kinase; reactivates the inactive form of AMP-activated protein kinase (AMP-pk); phosphorylates the 63-kD subunit of AMP-pk Registry number: EC 2.7.1.- Synonym: AMP-pk reactivator, hmg CoA reductase kinase kinase (26 Jun 1999) |
| calmodulin-dependent protein kinase IV kinase | <enzyme> Phosphorylates and activates cam-kinase iv; from brain Registry number: EC 2.7.10.- Synonym: cam-kinase iv kinase (26 Jun 1999) |
| MAPKAP kinase-2 reactivating kinase | <enzyme> A mapk-like enzyme; homologous to p42(mapk) and p44(mapk); activated by phosphorylation of serine/threonine and tyrosine residues Registry number: EC 2.7.1.- Synonym: mapkap kinase-2 rk (26 Jun 1999) |
| ribosomal protein S6 kinase kinase | <enzyme> Isolated from unfertilised xenopus eggs; a 41 kD enzyme that is associated, in vivo, with phosphorylation on threonine and tyrosine residues and, in vitro, with phosphorylation on serine as well Registry number: EC 2.7.1.- Synonym: rsk kinase (26 Jun 1999) |
| protein kinase B kinase | <enzyme> Phosphorylates and activates protein kinase b on threonine-308; requires phosphatidylinositol-3,4,5-trisphosphate Registry number: EC 2.7.10.- Synonym: upstream kinase, pkb kinase (26 Jun 1999) |
| leukocyte tyrosine kinase receptor tyrosine kinase | <enzyme> May be receptor for pre-b lymphocyte growth or differentiation factor; aa sequence given in first source Registry number: EC 2.7.1.- Synonym: ltk receptor tyrosine kinase, ltk receptor tk, ltk protein, leukocyte tyrosine kinase (ltk) (26 Jun 1999) |
| a1-trypsin inhibitor | A glycoprotein that is the major protease inhibitor of human serum, is synthesised in the liver, and is genetically polymorphic due to the presence of over 20 alleles; individuals appropriately homozygous are deficient in a1-trypsin and are predisposed to pulmonary emphysema and juvenile hepatic cirrhosis because of alterations in the amino acid and sialic acid components of the glycoprotein. A1-Antitrypsin also inhibits thrombin. Synonym: a1-trypsin inhibitor, human a1-proteinase inhibitor. (05 Mar 2000) |
| ACE inhibitor | <pharmacology> A group of antihypertensive medications that work by inhibiting an enzyme (angiotensin-converting enzyme) that is important in the regulation of blood pressure. Studies have also indicated that it may help prevent or slow the progression of kidney disease in patients with diabetes. Examples include: captopril, ramipril, enalapril, losartan potassium, bepridil and lisinopril. (12 Mar 1998) |
| aldose reductase inhibitor | <pharmacology> A class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes. Aldose reductase is an enzyme that is normally present in the eye and in many other parts of the body. It helps change glucose (sugar) into a sugar alcohol called sorbitol. Too much sorbitol trapped in eye and nerve cells can damage these cells, leading to retinopathy and neuropathy. Drugs that prevent or slow (inhibit) the action of aldose reductase are being studied as a way to prevent or delay these complications of diabetes. (09 Oct 1997) |
| angiotensin-converting enzyme inhibitor | <pharmacology> A class of drugs used in the treatment of hypertension and heart failure. They exert their haemodynamic effect mainly by inhibiting the renin-angiotensin system and produce a reduction of peripheral arterial resistance. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (14 Aug 2000) |
Synonyms : CDK2-Associated Protein 20 kDa, CDKN1 Protein, CDKN1A Protein, Cdk-Interacting Protein 1, Cdk2 Inhibitor Protein, Cell Cycle Regulator p21, Cyclin Kinase Inhibitor p21, Cyclin-Dependent Kinase Inhibitor 1A Protein, Senescent Cell-Derived Inhibitor Protein 1
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