| 영문 | Cushing's syndrome | 한글 | 쿠싱증후군 |
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| 설명 | 쿠싱증후군이란 글루코코르티코이드가 만성적으로 과잉분비에 의해서 일어나는 병을 말한다. 원인으로 ① 뇌하수체에서 ACTH가 과잉 분비되는 경우: 뇌하수체에서 ACTH가 너무나 많이 분비되는 경우에 부신겉질을 자극해서 많은 양의 글루코코르티코이드가 분비된다. ② 뇌하수체 이외의 부분에서 ACTH가 많이 분비되는 경우: 폐암, 난소암 등의 종양에서 ACTH를 생산하는 경우가 있다. 이 경우에도 역시 부신피질이 자극이 되어서 많은 양의 글루코코르티코이드가 분비된다. ③ ACTH의 자극이 없이 부신에서 많은 양의 글루코코르티코이드가 나오는 경우. ACTH자극에 관계없이 부신피질의 과잉성장, 종양에 의해서 많은 양의 글루코코르티코이드가 분비되는 경우. ④ 외인성, 의인성: 치료를 위해서 많은 양의 글루코코르티코이드를 장기 투여할 경우에 생기는 쿠싱증후군 쿠싱증후군에서 특히 ①번에 해당하는 것을 쿠싱병라고 한다. 증상은 뚱뚱하고 얼굴이 달덩이처럼 둥글고 살이 쪘지만 팔, 다리는 가늘고 대신에 몸에 많은 살이 붙어있다. 목뒤에 많은 살이 있어서 그것이 덩어리를 형성하기도 한다. 이것은 원래 글루코코르티코이드가 지방을 분해하는 역할을 하지만 병적으로 많이 나올 경우에는 지방의 분포를 변화시키는 역할을 하기 때문이다. 즉 팔, 다리 등의 온몸에 퍼져있는 지방을 몸통쪽으로 모두 이동시킨다. 잔털이 온몸에 걸쳐서 많이 나있고 여드름이 많고 배에 자주색 선조가 있는 경우가 많다. 그리고 글루코코르티코이드가 단백질을 분해해서 당류를 만드는 역할을 하여 근육이나 뼈대의 심한 소실이 있다. 그래서 근육이 거의 없어지고 뼈는 아주 부러지기 쉽게 된다. 대개 고혈압인 경우가 많고 심리적으로 우울증이나 과민성 등이 있을 수도 있고 심한 경우에는 정신병증세를 보이기도 한다. |
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| ECG | Electro-Cardio-Graphy(-Gram); 심전도 = EKG 1. Conducting System Structu... |
|---|---|
| AER | abduction/external rotation; acoustic evoked response; acute exertional rhabdomyolysis; agranular en... |
| SR | sarcoplasmic reticulum; saturation recovery; scanning radiometer; screen; secretion rate; sedimentat... |
| CS | calf serum; campomelic syndrome; carcinoid syndrome; cardiogenic shock; caries-susceptible; carotid ... |
| ERA | electrical response activity; electroencephalic response audiometry; Electroshock Research Associati... |
| CD | Cushing disease |
|---|---|
| CS | Cushing syndrome |
| TRE | 12-(O-tetradecanoylphorbol-13-acetate response element |
| APRF | 3/acute phase response factor |
| CREB | 4/cAMP response element-binding protein |
| Cushing response | A rise in systemic blood pressure when the intracranial pressure acutely increases, usually in excess of 50% of the systolic arterial pressure. Synonym: Cushing effect, Cushing response. (05 Mar 2000) |
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| cushing disease | <radiology> CNS disease resulting in Cushing syndrome, pituitary: corticotrophic adenoma, hypothalamic abnormality (12 Dec 1998) |
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| Cushing effect | A rise in systemic blood pressure when the intracranial pressure acutely increases, usually in excess of 50% of the systolic arterial pressure. Synonym: Cushing effect, Cushing response. (05 Mar 2000) |
| Cushing, Harvey | <person> This leader of neurosurgery was born in Cleveland, Ohio, graduated from Harvard in 1895, remained at Massachusetts General Hospital for one year, spent 15 years at Johns Hopkins, returned to Harvard as Professor of Surgery, and retired in new Haven where he continued actively until his death. Cushing's accomplishments in neurosurgery were amazing. In 1906, he demonstrated the relationship between pituitary tumours and sexual infantilism. In 1917, he published a classic, "The Pituitary Body and Its Disorders." Cushing wrote many charming essays, some of which were published as a collection under the title, "Consecratio Medici" in 1928. He was an earnest collector of books and bequeathed his valuable collection to the Yale Library. Among his many publications were a Biography of 0sler, and a Biography of Andreas Vesalius. Lived: 1869-1939. (15 Nov 1997) |
| Cushing, Hayward | <person> U.S. Surgeon, 1854-1934. See: Cushing's suture. (05 Mar 2000) |
| Cushing phenomenon | A rise in systemic blood pressure when the intracranial pressure acutely increases, usually in excess of 50% of the systolic arterial pressure. Synonym: Cushing effect, Cushing response. (05 Mar 2000) |
| Cushing's basophilism | <endocrinology, syndrome> An increased concentration of glucocorticoid hormone (ACTH) in the bloodstream that is being produced by an adrenal gland tumour (adenoma). Ectopic Cushing syndrome refers to the production of ACTH in a location other than the pituitary gland or adrenal gland. Examples of ectopic sites include thymoma, medullary carcinoma of the thyroid, pheochromocytoma, islet cell tumours of the pancreas and oat cell carcinoma of the lung. Symptoms include weight gain, central obesity, moon face, weakness, fatigue, backache, headache, increased thirst, increased urination, impotence, mental status changes and muscle atrophy. Treatment varies with cause. If an ACTH secreting tumour is involved then it must be removed surgically. (27 Sep 1997) |
| Cushing's disease | <disease> An increased concentration of glucocorticoid hormone in the bloodstream (produced by the adrenal gland) secondary to a pituitary tumour that is secreting the hormone adrenocorticotropic hormone (ACTH). ACTH serves to stimulate the adrenal gland to produce excess glucocorticoids. (27 Sep 1997) |
| Cushing's pituitary basophilism | <disease> An increased concentration of glucocorticoid hormone in the bloodstream (produced by the adrenal gland) secondary to a pituitary tumour that is secreting the hormone adrenocorticotropic hormone (ACTH). ACTH serves to stimulate the adrenal gland to produce excess glucocorticoids. (27 Sep 1997) |
| Cushing's suture | A running horizontal mattress suture used to approximate two adjacent surfaces. (05 Mar 2000) |
| Cushing's syndrome | <endocrinology, syndrome> An increased concentration of glucocorticoid hormone (ACTH) in the bloodstream that is being produced by an adrenal gland tumour (adenoma). Ectopic Cushing syndrome refers to the production of ACTH in a location other than the pituitary gland or adrenal gland. Examples of ectopic sites include thymoma, medullary carcinoma of the thyroid, pheochromocytoma, islet cell tumours of the pancreas and oat cell carcinoma of the lung. Symptoms include weight gain, central obesity, moon face, weakness, fatigue, backache, headache, increased thirst, increased urination, impotence, mental status changes and muscle atrophy. Treatment varies with cause. If an ACTH secreting tumour is involved then it must be removed surgically. (27 Sep 1997) |
| Cushing's syndrome medicamentosus | A variable number of the signs and symptoms of Cushing's syndrome; produced by the chronic administration of large doses of any steroid that is a potent glucocorticoid. (05 Mar 2000) |
| cushing syndrome | <radiology> Hyperplasia 70%, pituitary 90%, ectopic 10%, adrenal adenoma 20%, carcinoma 10% Findings: retarded bone maturation, osteoporosis (most often axial), excess callus formation, stippled calvarium, demineralised dorsum sellae, CT: normal-sized adrenals in 1/3 of adrenal hyperplasia (12 Dec 1998) |
| Harvey Cushing | <person> This leader of neurosurgery was born in Cleveland, Ohio, graduated from Harvard in 1895, remained at Massachusetts General Hospital for one year, spent 15 years at Johns Hopkins, returned to Harvard as Professor of Surgery, and retired in new Haven where he continued actively until his death. Cushing's accomplishments in neurosurgery were amazing. In 1906, he demonstrated the relationship between pituitary tumours and sexual infantilism. In 1917, he published a classic, "The Pituitary Body and Its Disorders." Cushing wrote many charming essays, some of which were published as a collection under the title, "Consecratio Medici" in 1928. He was an earnest collector of books and bequeathed his valuable collection to the Yale Library. Among his many publications were a Biography of 0sler, and a Biography of Andreas Vesalius. Lived: 1869-1939. (15 Nov 1997) |
| syndrome, cushing's | The constellation of symptoms and signs caused by an excess of cortisol hormone. Cushing syndrome is an extremely complex hormonal condition that involves many areas of the body. Common symptoms are thinning of the skin, weakness, weight gain, bruising, hypertension, diabetes, thin weak bones (osteoporosis), facial puffiness, and in women cessation of periods. Ironically, one of the commonest causes of cushing's syndrome is the administration of cortisol-like medications for the treatment of diverse diseases. All other cases of cushing's syndrome are due to excess production of cortisol by the adrenal gland including 1) an abnormal growth of the pituitary gland, which stimulates the adrenal gland, 2) a benign or malignant growth within the adrenal gland itself, which produces cortisol and 3) production within another part of the body (ectopic production) of a hormone that directly or indirectly stimulates the adrenal gland to make cortisol. Neurosurgeon harvey cushing (1869-1939) described hyperadrenocorticism (excessive production of cortisol by the adrenal gland) due quite specifically to an acth-secreting pituitary adenoma, a benign pituitary tumour that puts out acth (adrenocorticotropic hormone) which, in turn, drives (or overdrives) the adrenal gland to overproduce cortisol. (12 Dec 1998) |
| anamnestic response | <immunology> Archaic term now replaced by such terms as secondary immune response, immune memory. (18 Nov 1997) |
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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