| ABC | absolute basophil count; absolute bone conduction; acalculous biliary colic; acid balance control; a... |
|---|---|
| CD4 | HIV helper cell count |
| ACD | absolute cardiac dullness; absolute claudication distance; acid-citrate-dextrose [solution]; actinom... |
| ACR | abnormally contracting region; absolute catabolic rate; acriflavine; adenomatosis of colon and rectu... |
| AGC | absolute granulocyte count; automatic gain control |
| CD4+ | CD4 positive |
|---|---|
| h-CD4 | human CD4 |
| ALC | Absolute Lymphocyte Count |
| ANC | Absolute Neutrophil Count |
| AGC | absolute granulocyte count |
| absolute CD4 count | The number of helper T-lymphocytes in a cubic millimeter of blood. With HIV, the absolute CD4 count declines as the infection progresses. The absolute CD4 count is frequently used to monitor the extent of immune suppression in persons with HIV. Also called a T4 count. (12 Dec 1998) |
|---|---|
| CD4 count, absolute | The number of helper T-lymphocytes in a cubic millimeter of blood. With HIV, the absolute CD4 count declines as the infection progresses. The absolute CD4 count is frequently used to monitor the extent of immune suppression in persons with HIV. Also called a T4 count. (12 Dec 1998) |
| CD4/CD8 count | The ratio of the number of helper-inducer T lymphocytes to cytotoxic-suppressor T lymphocytes, as measured by monoclonal antibodies to the CD4 surface antigen found on helper-inducer T-cells, and the CD8 surface antigen found on cytotoxic-suppressor T-cells. In healthy individuals, the H/S ratio ranges between 1.6 and 2.2.When the body mounts an immune response, as against a virus or a transplant, the ratio is almost always reduced because of a decrease in the number of circulating helper-inducer cells and an increase in suppressor cells. The CD4/CD8 count has been used to monitor for signs of organ rejection after transplants, and more recently has become a tool for assessing the relative condition of HIV patients. With the CD4 absolute count and the CD4 lymphocyte percentage, it provides a way of gauging the progression from HIV to AIDS. (05 Mar 2000) |
| CD4 cell count | The most commonly used surrogate marker for assessing the state of the immune system. As CD4 cell count declines, the risk of developing opportunistic infections increases. The normal range for CD4 cell counts is 500 to 1500 per cubic millimetre of blood. CD4 count should be rechecked at least every six to twelve months if CD4s are greater than 500/mm3. If the count is lower, testing every three months is advised. (09 Oct 1997) |
| CD4 lymphocyte count | A count of the number of CD4-positive lymphocytes in the blood. Determination requires the use of a fluorescence-activated flow cytometer. (12 Dec 1998) |
| absolute eosinophil count | <haematology, investigation> A measurement (cells per microlitre) of the number of eosinophils in a blood specimen. This measurement is useful in the evaluation of autoimmune disease, allergies, eczema, leukaemia, asthma and hay fever. Normal absolute eosinophil counts are less than 350 cells/mcl (microlitre). (27 Sep 1997) |
| antigens, CD4 | <immunology> 55-kD glycoproteins originally defined as differentiation antigens on T-lymphocytes, but also found on other cells including monocytes/macrophages. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MHC (major histocompatibility complex) class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. Cd4 antigens also serve as HIV receptors, binding directly to the envelope protein gp120 on HIV. The protein structure on the surface of a human cell that allows HIV to attach, enter, and thus infect a cell. CD4 receptors are present on CD4 cells (helper T-cells), macrophages and dendritic cells, among others. Normally, CD4 acts as an accessory molecule, forming part of larger structures (such as the T-cell receptor) through which Tcells and other cells signal each other. (12 Dec 1998) |
| CD4 | <immunology> 55-kD glycoproteins originally defined as differentiation antigens on T-lymphocytes, but also found on other cells including monocytes/macrophages. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MHC (major histocompatibility complex) class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. Cd4 antigens also serve as HIV receptors, binding directly to the envelope protein gp120 on HIV. The protein structure on the surface of a human cell that allows HIV to attach, enter, and thus infect a cell. CD4 receptors are present on CD4 cells (helper T-cells), macrophages and dendritic cells, among others. Normally, CD4 acts as an accessory molecule, forming part of larger structures (such as the T-cell receptor) through which Tcells and other cells signal each other. (12 Dec 1998) |
| CD4:CD8 ratio | The ratio of CD4 to CD8 cells. A common measure of immune system status that is around two in healthy individuals. The ratio of T-lymphocytes that express the CD4 antigen to those that express the CD8 antigen. This value is commonly assessed in the diagnosis and staging of diseases affecting the immune system including HIV infection. (12 Dec 1998) |
| CD4 cell | T helper cells which are targets for HIV infection. (09 Oct 1997) |
| CD4 immunoadhesins | <immunology> Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the fc portion of immunoglobulins. These have potential use in the therapy of aids since they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as the long plasma half-life and fc receptor-binding functions of immunoglobulin. (12 Dec 1998) |
| CD4 lymphocyte | A specific type of lymphocyte, derived from the thymus gland, that plays an important role in cellular immunity. T4 lymphocytes (CD4 cells) are decreased (absolute counts less than 200) in patients with AIDS resulting in compromised immune function. (27 Sep 1997) |
| CD4-positive T-lymphocytes | A critical subpopulation of regulatory T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the t4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes, which includes both the helper-inducer (T-lymphocytes, helper-inducer) and suppressor-inducer (T-lymphocytes, suppressor-inducer) T-cells. (12 Dec 1998) |
| t-lymphocytopenia, idiopathic CD4-positive | Reproducible depletion of CD4+ lymphocytes below 300 per cubic millimeter in the absence of HIV infection or other known causes of immunodeficiency. This is a rare, heterogeneous syndrome and does not appear to be caused by a transmissible agent. (12 Dec 1998) |
| absolute | 1. Loosed from any limitation or condition; uncontrolled; unrestricted; unconditional; as, absolute authority, monarchy, sovereignty, an absolute promise or command; absolute power; an absolute monarch. 2. Complete in itself; perfect; consummate; faultless; as, absolute perfection; absolute beauty. "So absolute she seems, And in herself complete." (Milton) 3. Viewed apart from modifying influences or without comparison with other objects; actual; real; opposed to relative and comparative; as, absolute motion; absolute time or space. Absolute rights and duties are such as pertain to man in a state of nature as contradistinguished from relative rights and duties, or such as pertain to him in his social relations. 4. Loosed from, or unconnected by, dependence on any other being; self-existent; self-sufficing. In this sense God is called the Absolute by the Theist. The term is also applied by the Pantheist to the universe, or the total of all existence, as only capable of relations in its parts to each other and to the whole, and as dependent for its existence and its phenomena on its mutually depending forces and their laws. 5. Capable of being thought or conceived by itself alone; unconditioned; non-relative. It is in dispute among philosopher whether the term, in this sense, is not applied to a mere logical fiction or abstraction, or whether the absolute, as thus defined, can be known, as a reality, by the human intellect. "To Cusa we can indeed articulately trace, word and thing, the recent philosophy of the absolute." (Sir W. Hamilton) 6. Positive; clear; certain; not doubtful. "I am absolute 't was very Cloten." (Shak) 7. Authoritative; peremptory. "The peddler stopped, and tapped her on the head, With absolute forefinger, brown and ringed." (Mrs. Browning) 8. <chemistry> Pure; unmixed; as, absolute alcohol. 9. Not immediately dependent on the other parts of the sentence in government; as, the case absolute. See Ablative absolute, under Ablative. <geometry> Absolute curvature, the sum of the optic and eccentric equations. <physics> Absolute space, space considered without relation to material limits or objects. Absolute terms. <mathematics> The be ginning, or zero point, in the scale of absolute temperature. It is equivalent to -273 deg centigrade or -459.4 deg Fahrenheit. Synonym: Positive, peremptory, certain, unconditional, unlimited, unrestricted, unqualified, arbitrary, despotic, autocratic. Origin: L. Absolutus, p. P. Of absolvere: cf. F. Absolu. See Absolve. <geometry> In a plane, the two imaginary circular points at infinity; in space of three dimensions, the imaginary circle at infinity. Source: Websters Dictionary (01 Mar 1998) |
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