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CMO Corticosteroid Methyl-Oxidase
17-OHCS 17-OH(Hydroxy)-Corticosteroid
CBG capillary blood gases; coronary bypass graft; corticosteroid-binding globulin; cortisol-binding glob...
CBGv corticosteroid-binding globulin variant
CS calf serum; campomelic syndrome; carcinoid syndrome; cardiogenic shock; caries-susceptible; carotid ...
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11-OHCS 11-hydroxy-corticosteroid
17-OHCS 17-hydroxy-corticosteroid
C Corticosteroid
CBG Corticosteroid Binding Globulin
CR Corticosteroid-resistant
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corticosteroid <drug, endocrinology, pharmacology> Any of the steroids elaborated by the adrenal cortex (excluding the sex hormones of adrenal origin) in response to the release of adrenocorticotrophin or adrenocorticotropic hormone (ACTH) by the pituitary gland, to any of the synthetic equivalents of these steroids or to angiotensin II.
They are divided, according to their predominant biological activity, into three major groups: glucocorticoids (e.g. Cortisol, cortisone), chiefly influencing carbohydrate, fat and protein metabolism, mineralocorticoids (for example aldosterone), affecting the regulation of electrolyte and water balance and C19 androgens.
Some corticosteroids exhibit both types of activity in varying degrees and others exert only one type of effect.
The corticosteroids are used clinically for hormonal replacement therapy, for suppression of ACTH secretion by the anterior pituitary, as antineoplastic, antiallergic and anti-inflammatory agents and to suppress the immune response.
Synonym: adrenocortical hormone, corticoid.
(13 Nov 1997)
corticosteroid-binding globulin <chemical> Chemical name: Transcortins
(12 Dec 1998)
corticosteroid-binding protein <chemical> Chemical name: Transcortins
(12 Dec 1998)
corticosteroid cream <drug, pharmacology> This is a large group of trade name medications that contain an anti-inflammatory steroid. These cream based medications all contain either hydrocortisone in varying concentrations or a synthetic steroid with much greater potency. This type of medications is useful in the treatment of a large number of inflammatory rashes. Caution: higher potency creams can cause side effects.
Examples include hydrocortisone, dexamethasone, flunisolide, fluocinonide, fluprednisolone, Aclovate, Alphatrex, Aristocort, Betatrex, Cortone, Diprolene, Valisone, Halog, Hytone, Kenalog, Lidex, Lotrisone, Synalar, Synemol, Topicort, Vytone, Westcort and Vioform.
(27 Sep 1997)
corticosteroid-induced acne The exacerbation of acne after corticosteroid use is a common drug reaction seen in adolescents. Lessening the dose of the corticosteroid will often diminish this effect.
(27 Sep 1997)
corticosteroid-induced glaucoma <ophthalmology> Glaucoma caused by a hereditary predisposition in which local instillation of eyedrops containing corticosteroid causes increased intraocular pressure.
(05 Mar 2000)
corticosteroid-induced striae <dermatology> High-dose glucocorticoid therapy causes atrophy of the skin and a failure of the normal regenerative process. Purple striae often develop over the individual's trunk or thighs. The colour fades when the drug is stopped, but the dermal atrophy remains.
(27 Sep 1997)
corticosteroid side-chain-isomerase <enzyme> Converts 11-deoxycorticosterone to 20-hydroxy-3-oxypregn-4-en-21-al; also acts as an epimerase at c-20
Registry number: EC 5.3.1.21
Synonym: corticosteroid side chain isomerase, ccsci
(26 Jun 1999)
allergy 1. <immunology> A state of hypersensitivity induced by exposure to a particular antigen (allergen) resulting in harmful immunologic reactions on subsequent exposures, the term is usually used to refer to hypersensitivity to an environmental antigen (atopic allergy or contact dermatitis) or to drug allergy.
The original meaning, now obsolete, included all states of altered immunologic reactivity, immunity as well as hypersensitivity. Gell and Coombs used the term allergic reaction to mean any harmful immunologic reaction causing tissue injury.
2. <study> The medical specialty dealing with diagnosis and treatment of allergic disorders.
(18 Nov 1997)
allergy and immunology A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.
(12 Dec 1998)
allergy desensitization Stimulation of the immune system with gradually increasing doses of the substances to which a person is allergic, the aim being to modify or stop the allergy war (by reducing the strength of the IgE and its effect on the mast cells). This form of treatment is very effective for allergies to pollen, mites, cats, and especially stinging insects (e.g., bees, hornets, yellowjackets, wasps, velvet ants, fire ants). Allergy immunotherapy usually takes 6 months to a year to become effective and injections ( shots ) are usually required for 3-5 years.
(12 Dec 1998)
allergy shots See Allergy desensitization.
(12 Dec 1998)
allergy skin test Test done on the skin to identify the allergy substance (allergen) triggering the allergic reaction. A small amount of the suspected allergy substance is placed on the skin. The skin is then gently scratched through the small drop with a special sterile needle. If the skin reddens and, more importantly, swells, then allergy to that substance is probable.
(12 Dec 1998)
allergy testing <investigation> A common method of screening a patient for potential allergies. May be given as a patch or a skin test (injection).
(27 Sep 1997)
atopic allergy <immunology> An allergic reaction with strong family tendencies.
(09 Oct 1997)
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