| Coronaviridae | <virology> Family of single stranded RNA viruses responsible for respiratory diseases. The outer envelope of the virus has club shaped projections that radiate outwards and give a charateristic corona appearance to negatively stained virions. (18 Nov 1997) |
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| coronaviridae infections | Virus diseases caused by coronaviridae. (12 Dec 1998) |
Synonyms :
Synonyms : Infections, Coronaviridae, Coronaviridae Infection, Infection, Coronaviridae
| Coronaviridae |
the coronaviruses and toroviruses: a family of RNA viruses having a pleomorphic virion 120160 nm in diameter consisting of a lipid-containing membrane, with large peplomers, surrounding a helical (for coronaviruses) or tubular (for toroviruses) nucleocapsid. The genome consists of a single molecule of positive-sense single-stranded polyadenylated RNA (MW 5.56.1 × 106, size about 30 kb for coronaviruses and 20 kb for toroviruses). Viruses contain three major structural polypeptides and are resistant to trypsin but sensitive to lipid solvents, detergents, ultraviolet radiation, disinfectants, and heat. Replicating occurs in the cytoplasm and assembly is by budding, usually through intracytoplasmic membranes; virions are released by exocytosis or by cell destruction. Transmission is mechanical, including airborne particles, contaminated equipment, and contact with infected persons. Included here are the genera Coronavirus and Torovirus.
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