| REV | reticuloendotheliosis virus |
|---|---|
| ReV | regulator of virion |
| rev | reverse; review; revolution |
| ECG | Electro-Cardio-Graphy(-Gram); ½ÉÀüµµ = EKG 1. Conducting System Structu... |
| AAPL | American Academy of Psychiatry and the Law |
| RRE | REV response element |
|---|---|
| REV | Reticuloendotheliosis virus |
| REV-T | Reticuloendotheliosis virus strain T |
| RRE | Rev Responsive Element |
| REV | reverse phase evaporation |
| anaemia, Cooley's | Better known today as thalassaemia (or as beta thalassaemia or thalassaemia major).The clinical picture of this important type of anaemia was first described in 1925 by the paediatrician Thomas Benton Cooley. Another name for the disease is Mediterranean anaemia. The name thalassaemia was coined by the Nobel Prise winning pathologist George Whipple and the professor of paediatrics Wm Bradford at Univ. Of Rochester because thalassa in Greek means the sea (like the Mediterrranean Sea) + -aemia means in the blood so thalassaemia means sea in the blood. Thalassaemia is not just one disease. It is a complex contingent of genetic (inherited) disorders all of which involve underproduction of haemoglobin, the indispensable molecule in red blood cells that carries oxygen. The globin part of normal adult haemoglobin is made up of 2 alpha and 2 beta polypeptide chains. In beta thalassaemia, there is a mutation (change) in both beta globin chains leading to underproduction (or absence) of beta chains, underproduction of haemoglobin, and profound anaemia. The gene for beta thalassaemia is relatively frequent in people of Mediterranean origin (for example, from Italy and Greece). Children with this disease inherit one gene for it from each parent. The parents are carriers (heterozygotes) with just one thalassaemia gene, are said to have thalassaemia minor, and are essentially normal. Their children affected with beta thalassaemia seem entirely normal at birth because at birth we still have predominantly foetal haemoglobin which does not contain beta chains. The anaemia surfaces in the first few months after birth and becomes progressively more severe leading to pallor and easy fatiguability, failure to thrive (grow), bouts of fever (due to infections) and diarrhoea. Treatment based on blood transfusions is helpful but not curative. Gene therapy will, it is hoped, be applicable to this disease. (12 Dec 1998) |
|---|---|
| gene products, rev | Trans-acting nuclear proteins whose functional expression are required for HIV viral replication. Specifically, the rev gene products are required for processing and translation of the HIV gag and env mRNAs, and thus rev regulates the expression of the viral structural proteins. Rev can also regulate viral regulatory proteins. A cis-acting antirepression sequence (car) in env, also known as the rev-responsive element (rre), is responsive to the rev gene product. Rev is short for regulator of virion. (12 Dec 1998) |
| genes, rev | DNA sequences that form the coding region for a protein that regulates the expression of the viral structural and regulatory proteins in human immunodeficiency virus (HIV). Rev is short for regulator of virion. (12 Dec 1998) |
| rev | <molecular biology> A regulatory protein produced by HIV within infected cells. Rev helps transport HIV RNA sequences (messenger RNA) out from the nucleus into the cells cytoplasm, where it directs construction of proteins for new virus particles. (11 Jan 1998) |
| Cooley's anaemia | <haematology> A genetic disease that results when there is a defect in the synthesis of one (or more) of the subunits of haemoglobin. The subunits are referred to as alpha or beta globin chains. As a result of a genetic defect red blood cells are small and hypochromic (low haemoglobin in the cell). Anaemia is common. Incidence is approximately 4 out of 100,000 individuals. Genetic testing is recommended in pregnant females of Mediterranean descent for the purpose of identifying carriers of this potentially serious genetic disease. Origin: Gr. Haima = blood (27 Sep 1997) |
| Cooley, Thomas | <person> U.S. Paediatrician, 1871-1945. See: Cooley's anaemia. (05 Mar 2000) |
| Abbe's law of limiting resolution | <physics> For a periodic structure of units separated by distance d and obliquely illuminated by the unrefracted ray and one of the two diffracted rays (extremely oblique illumination). Abbe applied the law of diffraction: d = 0.5 lambda /NA, where: lambda = wavelength of the monochromic light or shortest of mixed wavelengths NA = the limiting numerical aperture (NA) of objective or condenser. (05 Aug 1998) |
| all or none law | Consistently total response to any effective stimulus. Synonym: all or none law. (05 Mar 2000) |
| American Law Institute formulation | Used in certain jurisdictions to determine criminal responsibility in legal proceedings. See: criminal insanity. (05 Mar 2000) |
| American Law Institute rule | A test of criminal responsibility (1962): "a person is not responsible for criminal conduct if at the time of such conduct as a result of mental disease or defect he lacks substantial capacity either to appreciate the wrongfulness of his conduct or to conform his conduct to the requirements of law." (05 Mar 2000) |
| Ampere's law | <physics> General equation in electromagnetism relating the magnetic field and the currents generating it. The various forms of the equation can be found in an introductory electromagnetism text. (09 Oct 1997) |
| Angstrom's law | A substance absorbs light of the same wavelength as it emits when luminous. (05 Mar 2000) |
| Arndt's law | An obsolete law stating that weak stimuli excite physiologic activity, moderately strong ones favour it, strong ones retard it, and very strong ones arrest it. (05 Mar 2000) |
| Arrhenius law | The theory of electrolytic dissociation (1887) that became the basis of our modern understanding of electrolytes: in an electrically conductive solution (e.g., acid, base, or salt), free ions are present before electrolysis, and the proportion of molecules dissociated into ions can be calculated from measurements of electrical conductivity as well as of osmotic pressure. Synonym: Arrhenius law. (05 Mar 2000) |
| Avogadro's law | Equal volumes of gases contain equal numbers of molecules, the conditions of pressure and temperature being the same. Synonym: Ampere's postulate, Avogadro's hypothesis, Avogadro's postulate. (05 Mar 2000) |
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