| CR | calculation rate; calculus removed; calorie-restricted; cardiac rehabilitation; cardiac resuscitatio... |
|---|---|
| AIDSDRUGS | clinical trials of acquired immunodeficiency drugs [MEDLARS data base] |
| AIDSTRIALS | clinical trials of acquired immunodeficiency syndrome drugs [MEDLARS data base] |
| CTN | calcitonin; clinical trials notification; computer tomography number; continuous noise |
| CTS | carpal tunnel syndrome; clinical trials support [program]; composite treatment score; computed tomog... |
| CCTs | Controlled clinical trials |
|---|---|
| RCT | Randomized controlled clinical trials |
| ACTG | AIDS Clinical Trials Group |
| PACTG | Paediatric AIDS Clinical Trials Group |
| CCTR | Cochrane Controlled Trial Register |
| controlled clinical trials | Clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterised as randomised controlled trials. However, trials employing treatment allocation methods such as coin flips, odd-even numbers, patient social security numbers, days of the week, medical record numbers, or other such pseudo- or quasi-random processes, are simply designated as controlled clinical trials. (12 Dec 1998) |
|---|---|
| randomised controlled trials | Clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table. Treatment allocations using coin flips, odd-even numbers, patient social security numbers, days of the week, medical record numbers, or other such pseudo- or quasi-random processes, are not truly randomised and trials employing any of these techniques for patient assignment are designated simply controlled clinical trials. (12 Dec 1998) |
| clinical research trials | Evaluating the safety and effectiveness of medications or medical devices by monitoring their effects on large groups of people. Clinical medical trials sponsored by the U. S. Government are listed on a web site of the National Institutes of Health (NIH). The NIH Clinical Centre intends to make details of current clinical research studies for various diseases available over the Internet to increase opportunities for patients and physicians to participate in clinical investigations. (12 Dec 1998) |
| clinical trials | Medical research studies conducted with volunteers. Each study is designed to answer scientific questions and to find better ways to prevent, detect, or treat cancer. (12 Dec 1998) |
| clinical trials, phase I | Studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the u.s. And in other countries. (12 Dec 1998) |
| clinical trials, phase II | Studies that are usually controlled to assess the effectiveness and dosage (if appropriate) of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques. These studies are performed on several hundred volunteers, including a limited number of patients with the target disease or disorder, and last about two years. This concept includes phase II studies conducted in both the u.s. And in other countries. (12 Dec 1998) |
| clinical trials, phase III | Comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the u.s. And in other countries. (12 Dec 1998) |
| clinical trials, phase IV | Planned post-marketing studies of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale. These studies are often conducted to obtain additional data about the safety and efficacy of a product. This concept includes phase IV studies conducted in both the u.s. And in other countries. (12 Dec 1998) |
| controlled clinical trial | A clinical trial involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicine, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trial is characterised as a randomised controlled trial. However, trials employing treatment allocation methods such as coin flips, odd-even numbers, patient social security numbers, days of the week, medical record numbers, or other such pseudo- or quasi-random processes are simply designated as controlled clinical trials. (12 Dec 1998) |
| analgesia, patient-controlled | Relief of pain, without loss of consciousness, through an analgesic agent administered by the patient. It has been used successfully to control postoperative pain, during labour, after burns, and in terminal care. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimised by combining small bolus doses with a mandatory interval between successive doses (lockout interval). (12 Dec 1998) |
| randomised controlled trial | A clinical trial that involves at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table. Treatment allocations using coin flips, odd-even numbers, patient social security numbers, days of the week, medical record numbers, or other such pseudo- or quasi-random processes, are not truly randomised and a trial employing any of these techniques for patient assignment is designated simply a controlled clinical trial. (12 Dec 1998) |
| patient controlled analgesia | <anaesthetics, procedure> Self-administration of analgesics by a patient instructed in doing so, usually refers to self-dosing with intravenous opioid (for example, morphine) administered by means of a programmable pump. (16 Dec 1997) |
| vocabulary, controlled | A means of access to information (including bibliographic records, factual data, images, collections, etc.) limited to a specified list of terms with a fixed and unalterable meaning, and from which a selection is made when cataloging, indexing, or searching books, journals, and other documents. The control is intended to avoid the scattering of related subjects under different headings. The list may be altered or extended only by the publisher or issuing agency. (12 Dec 1998) |
| research, controlled | The first controlled clinical research was probably done in 1875 by the british naval surgeon james lind who, on board the hms salisbury, gave sailors with scurvy either oranges or lemons or cider or vinegar or nutmeg (or another treatment) and after just six days discovered that the citrus-consuming sailors had recovered from scury, until then the scourge of extended sea voyages, while the sailors who had been given the other treatments remained uncured. (12 Dec 1998) |
| volume-controlled respirator | A respirator that provides a predetermined volume of gases during inhalation, with the pressure required to move that volume remaining variable, depending upon resistance. (05 Mar 2000) |
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