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CD4 HIV helper cell count
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ICL Idiopathic CD4 + T Lymphocytopenia
ICL idiopathic CD4 T-cell lymphocytopenia; iris-clip lens; isocitrate lyase
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CD4+ CD4 positive
CD40L CD40
CD40L CD40 Ligand
CD40L CD40-CD40 ligand
CD44-S CD44
CD44S CD44 standard
CD44v CD44
CD44v CD44 variant
CD44v CD44 variant isoform
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h-CD4 human CD4
ICL Idiopathic CD4 T lymphocytopenia
rCD4 Recombinant CD4
rsCD4 Recombinant soluble CD4
sCD4 Soluble CD4
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CD4 <immunology> 55-kD glycoproteins originally defined as differentiation antigens on T-lymphocytes, but also found on other cells including monocytes/macrophages. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MHC (major histocompatibility complex) class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. Cd4 antigens also serve as HIV receptors, binding directly to the envelope protein gp120 on HIV.
The protein structure on the surface of a human cell that allows HIV to attach, enter, and thus infect a cell. CD4 receptors are present on CD4 cells (helper T-cells), macrophages and dendritic cells, among others. Normally, CD4 acts as an accessory molecule, forming part of larger structures (such as the T-cell receptor) through which Tcells and other cells signal each other.
(12 Dec 1998)
CD4 cell T helper cells which are targets for HIV infection.
(09 Oct 1997)
CD4 cell count The most commonly used surrogate marker for assessing the state of the immune system. As CD4 cell count declines, the risk of developing opportunistic infections increases. The normal range for CD4 cell counts is 500 to 1500 per cubic millimetre of blood. CD4 count should be rechecked at least every six to twelve months if CD4s are greater than 500/mm3. If the count is lower, testing every three months is advised.
(09 Oct 1997)
CD4 count, absolute The number of helper T-lymphocytes in a cubic millimeter of blood. With HIV, the absolute CD4 count declines as the infection progresses. The absolute CD4 count is frequently used to monitor the extent of immune suppression in persons with HIV. Also called a T4 count.
(12 Dec 1998)
CD4 immunoadhesins <immunology> Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the fc portion of immunoglobulins. These have potential use in the therapy of aids since they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as the long plasma half-life and fc receptor-binding functions of immunoglobulin.
(12 Dec 1998)
CD4 lymphocyte A specific type of lymphocyte, derived from the thymus gland, that plays an important role in cellular immunity. T4 lymphocytes (CD4 cells) are decreased (absolute counts less than 200) in patients with AIDS resulting in compromised immune function.
(27 Sep 1997)
CD4 lymphocyte count A count of the number of CD4-positive lymphocytes in the blood. Determination requires the use of a fluorescence-activated flow cytometer.
(12 Dec 1998)
CD4-positive T-lymphocytes A critical subpopulation of regulatory T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the t4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes, which includes both the helper-inducer (T-lymphocytes, helper-inducer) and suppressor-inducer (T-lymphocytes, suppressor-inducer) T-cells.
(12 Dec 1998)
CD4/CD8 count The ratio of the number of helper-inducer T lymphocytes to cytotoxic-suppressor T lymphocytes, as measured by monoclonal antibodies to the CD4 surface antigen found on helper-inducer T-cells, and the CD8 surface antigen found on cytotoxic-suppressor T-cells. In healthy individuals, the H/S ratio ranges between 1.6 and 2.2.When the body mounts an immune response, as against a virus or a transplant, the ratio is almost always reduced because of a decrease in the number of circulating helper-inducer cells and an increase in suppressor cells. The CD4/CD8 count has been used to monitor for signs of organ rejection after transplants, and more recently has become a tool for assessing the relative condition of HIV patients. With the CD4 absolute count and the CD4 lymphocyte percentage, it provides a way of gauging the progression from HIV to AIDS.
(05 Mar 2000)
CD40 <immunology> Differentiation antigens found on all mature B-lymphocytes and some epithelial cells, carcinomas, and lymphoid dendritic cells. This is a member of the tumour necrosis factor superfamily. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centres.
(12 Dec 1998)
CD44 <immunology> Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. Cd44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules.
(12 Dec 1998)
CD45 <immunology> High-molecular weight glycoproteins uniquely expressed on the surface of all leukocytes and their haemopoietic progenitors. The CD45 family consists of multiple members that are all products of a single gene. Cd45 expression is necessary for signalling through the T-cell receptor.
(12 Dec 1998)
CD45 phosphatase <enzyme> Reverses glycoprotein cd3-induced microtubule-associated protein-2 kinase activity in jurkat t-cells
Registry number: EC 3.1.3.-
Synonym: glycoprotein-cd45 phosphatase, cd45 ptpase, cd45 phosphotyrosine phosphatase
(26 Jun 1999)
CD4:CD8 ratio The ratio of CD4 to CD8 cells. A common measure of immune system status that is around two in healthy individuals. The ratio of T-lymphocytes that express the CD4 antigen to those that express the CD8 antigen. This value is commonly assessed in the diagnosis and staging of diseases affecting the immune system including HIV infection.
(12 Dec 1998)
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absolute CD4 count The number of helper T-lymphocytes in a cubic millimeter of blood. With HIV, the absolute CD4 count declines as the infection progresses. The absolute CD4 count is frequently used to monitor the extent of immune suppression in persons with HIV. Also called a T4 count.
(12 Dec 1998)
antigens, CD4 <immunology> 55-kD glycoproteins originally defined as differentiation antigens on T-lymphocytes, but also found on other cells including monocytes/macrophages. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MHC (major histocompatibility complex) class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. Cd4 antigens also serve as HIV receptors, binding directly to the envelope protein gp120 on HIV.
The protein structure on the surface of a human cell that allows HIV to attach, enter, and thus infect a cell. CD4 receptors are present on CD4 cells (helper T-cells), macrophages and dendritic cells, among others. Normally, CD4 acts as an accessory molecule, forming part of larger structures (such as the T-cell receptor) through which Tcells and other cells signal each other.
(12 Dec 1998)
t-lymphocytopenia, idiopathic CD4-positive Reproducible depletion of CD4+ lymphocytes below 300 per cubic millimeter in the absence of HIV infection or other known causes of immunodeficiency. This is a rare, heterogeneous syndrome and does not appear to be caused by a transmissible agent.
(12 Dec 1998)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 5 ÆäÀÌÁö: 1
  • CD4 Immunoadhesins - »õâ Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc portion of immunoglobulins. These have potential use in the therapy of AIDS since they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as the long plasma half-life and Fc receptor-binding functions of immunoglobulin.
    Synonyms : CD4 IgG
  • CD4 Lymphocyte Count - »õâ The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
    Synonyms : CD4 Cell Counts, CD4 Counts, CD4+ Cell Counts, CD4+ Counts, CD4 Cell Count, CD4 Count, CD4 Lymphocyte Counts, CD4+ Cell Count, CD4+ Count, Count, T4 Lymphocyte, Counts, T4 Lymphocyte, Lymphocyte Count, T4, Lymphocyte Counts, CD4, Lymphocyte Counts, T4
  • CD4-CD8 Ratio - »õâ Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.
    Synonyms : CD4 CD8 Ratio, CD4-CD8 Ratios, T4 T8 Ratio, T4-T8 Ratios
  • CD4-Positive T-Lymphocytes - »õâ A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
    Synonyms : CD4-Positive Lymphocytes, CD4 Positive T Lymphocytes, CD4-Positive Lymphocyte, CD4-Positive T-Lymphocyte, Lymphocyte, CD4-Positive, Lymphocytes, CD4-Positive, T-Lymphocyte, CD4-Positive, T-Lymphocytes, CD4-Positive, T4 Cell, T4 Lymphocyte
  • CD40 Ligand - »õâ A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.
    Synonyms : Antigen, CD154, CD154 Antigen, CD40L, T-B Cell Activating Molecule, TNF Superfamily, Member 5, gp39 Antigen, T-Cell, T-Cell gp39 Antigen, gp39 Antigen, T Cell
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CD4 cluster of differentiation 4: a glycoprotein that is found primarily on the surface of helper T cells; "CD4 is a receptor for HIV in humans"
Ãâó: wordnet.princeton.edu/perl/webwn
CD4 count this is a measure of the strength of the immune system. HIV continually kills CD4 cells. Over time, the body can not replace these lost CD4 cells and their number declines. When this happens the body will be more susceptible to infections. A normal CD4 count is 1000. The body starts to get more frequent common infections at around a count of 400. At around a CD4 count of 200 the body becomes susceptible to many unusual infections. ...
Ãâó: depts.washington.edu/madclin/patients/glossary.htm...
CD4 the cell surface protein CD4 is important for recognition by the T cell receptor of antigenic peptides bound to MHC class II molecules. It acts as a co-receptor by binding to the lateral face of MHC class II molecules.
Ãâó: www.sabin.org/vaccine_science_GlossaryB_D.htm
CD4 Another name for a "helper" T-cell.
Ãâó: www.epidemic.org/glossaryText/glossaryC.html
CD4 1. A glycoprotein predominantly found on the surface of helper T cells. In humans, it is a receptor for HIV, enabling the virus to gain entry into its host. 2. A cell bearing the CD4 surface receptor.
Ãâó: student.biology.arizona.edu/honors2002/group09/glo...
WordNet ÀÏ¹Ý ¿µ¿µ »çÀü °Ë»ö °á°ú : 2 ÆäÀÌÁö: 1
CD4 T cell with CD4 receptor that recognizes antigens on the surface of a virus-infected cell and secretes lymphokines that stimulate B cells and killer T cells
CD4 T cell with CD4 receptor that recognizes antigens on the surface of a virus-infected cell and secretes lymphokines that stimulate B cells and killer T cells
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