| BCL | basic cycle length; B-cell leukemia/lymphoma |
|---|---|
| BCLL | B-cell chronic lymphocytic leukemia |
| BCLP | bilateral cleft of lip and palate |
| BCLS | basic cardiac life support |
| BCL | B cell lymphoma |
|---|---|
| BCL | Basic Cycle Length |
| BCL1 | B cell leukemia |
| BCLP | bilateral cleft lip and palate |
| BH | BCL-2 homology |
|---|
| bcl | <oncogene> Two variants of this oncogene are recognised. 1. Bcl-2: A proto-oncogene, activated by chromosome translocation in human B-cell lymphomas (hence bcl). Encodes a plasma membrane protein. The gene product inhibits programmed cell death (apoptosis) and is homologous with the worm gene ced 9. See: ced mutant. 2. Bcl-3: An oncogene associated with some cases of B-cell chronic lymphocytic leukaemias. The protein product contains seven ankyrin repeats very similar to those found in I kappa B. Seems to interfere with binding of 50 kD subunit of NF kappa B to DNA. (24 Mar 1998) |
|---|---|
| bcl-2 | <oncogene> Two variants of this oncogene are recognised. 1. Bcl-2: A proto-oncogene, activated by chromosome translocation in human B-cell lymphomas (hence bcl). Encodes a plasma membrane protein. The gene product inhibits programmed cell death (apoptosis) and is homologous with the worm gene ced 9. See: ced mutant. 2. Bcl-3: An oncogene associated with some cases of B-cell chronic lymphocytic leukaemias. The protein product contains seven ankyrin repeats very similar to those found in I kappa B. Seems to interfere with binding of 50 kD subunit of NF kappa B to DNA. (24 Mar 1998) |
| bcl-3 | <oncogene> Two variants of this oncogene are recognised. 1. Bcl-2: A proto-oncogene, activated by chromosome translocation in human B-cell lymphomas (hence bcl). Encodes a plasma membrane protein. The gene product inhibits programmed cell death (apoptosis) and is homologous with the worm gene ced 9. See: ced mutant. 2. Bcl-3: An oncogene associated with some cases of B-cell chronic lymphocytic leukaemias. The protein product contains seven ankyrin repeats very similar to those found in I kappa B. Seems to interfere with binding of 50 kD subunit of NF kappa B to DNA. (24 Mar 1998) |
| genes, bcl-1 | The B-cell leukaemia/lymphoma-1 genes, associated with various neoplasms when overexpressed. Overexpression results from the t(11;14) translocation, which is characteristic of mantle zone-derived B-cell lymphomas. The human c-bcl-1 gene is located at 11q13 on the long arm of chromosome 18. (12 Dec 1998) |
|---|---|
| genes, bcl-2 | The B-cell leukaemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18. (12 Dec 1998) |
| proto-oncogene proteins c-bcl-2 | Membrane proteins encoded by the bcl-2 genes and serving as a potent inhibitor of cell death by apoptosis. The proteins are found on mitochondrial, microsomal, and nuclear membrane sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. (12 Dec 1998) |
Synonyms : N-Bak Protein, bcl2 Homologous Antagonist-Killer Protein, bcl 2 Homologous Antagonist Killer Protein, bcl2 Homologous Antagonist Killer Protein
Synonyms : Bax Apoptosis Regulator Protein, Bax-beta Protein, Bax-delta Protein, bcl2-Associated X Protein, bcl2-Associated X Protein Isoform alpha, bcl2-Associated X Protein Isoform beta, bcl2-Associated X Protein Isoform delta, bcl2-Associated X Protein Isoform omega
Synonyms : Bad Protein, bcl2-Antagonist of Cell Death Protein, Death Protein, bcl-Associated, bcl Associated Death Protein, bcl2 Antagonist of Cell Death Protein
Synonyms : bcl-X(L) Protein, bcl-X(S) Protein, bcl-Xa Protein, bcl-Xalpha Protein, bcl-Xb Protein, bcl-Xbeta Protein, bcl-Xlong Protein, bcl-Xshort Protein, bcl-x(beta) Protein, bcl2-Like 1 Protein, bcl2L1 Protein, bcl X Protein, bcl XL Protein, bcl XS Protein, bcl Xa Protein
| BCL2 |
An anti-apoptotic protein. It is the founding member of the BCL2 family of pro- and anti-apoptotic proteins.
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