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BCL basic cycle length; B-cell leukemia/lymphoma
BCLL B-cell chronic lymphocytic leukemia
BCLP bilateral cleft of lip and palate
BCLS basic cardiac life support
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BCL B cell lymphoma
BCL Basic Cycle Length
BCL1 B cell leukemia
BCLP bilateral cleft lip and palate
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BH BCL-2 homology
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  • bcl gene
    bcl À¯ÀüÀÚ
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bcl <oncogene> Two variants of this oncogene are recognised.
1. Bcl-2: A proto-oncogene, activated by chromosome translocation in human B-cell lymphomas (hence bcl). Encodes a plasma membrane protein. The gene product inhibits programmed cell death (apoptosis) and is homologous with the worm gene ced 9.
See: ced mutant.
2. Bcl-3: An oncogene associated with some cases of B-cell chronic lymphocytic leukaemias. The protein product contains seven ankyrin repeats very similar to those found in I kappa B. Seems to interfere with binding of 50 kD subunit of NF kappa B to DNA.
(24 Mar 1998)
bcl-2 <oncogene> Two variants of this oncogene are recognised.
1. Bcl-2: A proto-oncogene, activated by chromosome translocation in human B-cell lymphomas (hence bcl). Encodes a plasma membrane protein. The gene product inhibits programmed cell death (apoptosis) and is homologous with the worm gene ced 9.
See: ced mutant.
2. Bcl-3: An oncogene associated with some cases of B-cell chronic lymphocytic leukaemias. The protein product contains seven ankyrin repeats very similar to those found in I kappa B. Seems to interfere with binding of 50 kD subunit of NF kappa B to DNA.
(24 Mar 1998)
bcl-3 <oncogene> Two variants of this oncogene are recognised.
1. Bcl-2: A proto-oncogene, activated by chromosome translocation in human B-cell lymphomas (hence bcl). Encodes a plasma membrane protein. The gene product inhibits programmed cell death (apoptosis) and is homologous with the worm gene ced 9.
See: ced mutant.
2. Bcl-3: An oncogene associated with some cases of B-cell chronic lymphocytic leukaemias. The protein product contains seven ankyrin repeats very similar to those found in I kappa B. Seems to interfere with binding of 50 kD subunit of NF kappa B to DNA.
(24 Mar 1998)
CancerWEB ¿µ¿µ ÀÇÇлçÀü À¯»ç °Ë»ö °á°ú : 3 ÆäÀÌÁö: 1
genes, bcl-1 The B-cell leukaemia/lymphoma-1 genes, associated with various neoplasms when overexpressed. Overexpression results from the t(11;14) translocation, which is characteristic of mantle zone-derived B-cell lymphomas. The human c-bcl-1 gene is located at 11q13 on the long arm of chromosome 18.
(12 Dec 1998)
genes, bcl-2 The B-cell leukaemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.
(12 Dec 1998)
proto-oncogene proteins c-bcl-2 Membrane proteins encoded by the bcl-2 genes and serving as a potent inhibitor of cell death by apoptosis. The proteins are found on mitochondrial, microsomal, and nuclear membrane sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
(12 Dec 1998)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 4 ÆäÀÌÁö: 1
  • bcl-2 Homologous Antagonist-Killer Protein - »õâ A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.
    Synonyms : N-Bak Protein, bcl2 Homologous Antagonist-Killer Protein, bcl 2 Homologous Antagonist Killer Protein, bcl2 Homologous Antagonist Killer Protein
  • bcl-2-Associated X Protein - »õâ A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.
    Synonyms : Bax Apoptosis Regulator Protein, Bax-beta Protein, Bax-delta Protein, bcl2-Associated X Protein, bcl2-Associated X Protein Isoform alpha, bcl2-Associated X Protein Isoform beta, bcl2-Associated X Protein Isoform delta, bcl2-Associated X Protein Isoform omega
  • bcl-Associated Death Protein - »õâ A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. Unphosphorylated Bad protein inhibits the activity of BCL-XL PROTEIN.
    Synonyms : Bad Protein, bcl2-Antagonist of Cell Death Protein, Death Protein, bcl-Associated, bcl Associated Death Protein, bcl2 Antagonist of Cell Death Protein
  • bcl-X Protein - »õâ A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL.
    Synonyms : bcl-X(L) Protein, bcl-X(S) Protein, bcl-Xa Protein, bcl-Xalpha Protein, bcl-Xb Protein, bcl-Xbeta Protein, bcl-Xlong Protein, bcl-Xshort Protein, bcl-x(beta) Protein, bcl2-Like 1 Protein, bcl2L1 Protein, bcl X Protein, bcl XL Protein, bcl XS Protein, bcl Xa Protein
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BCL2 An anti-apoptotic protein. It is the founding member of the BCL2 family of pro- and anti-apoptotic proteins.
Ãâó: www.nature.com/nrm/journal/v5/n10/glossary/nrm1491...
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