| 영문 | alkylating agent | 한글 | 알킬화약물 |
|---|---|---|---|
| 설명 | 항암제의 일종. 이상적인 항암제는 정상적인 세포에는 해를 주지 않고 단지 암세포에만 치명적인 효과를 나타내야 한다. 이렇게 하려면 암세포만의 특이한 특성을 이해하고 그곳에만 작용하는 약물을 개발해야 한다. 현재 대부분의 항암제는 암세포가 정상 세포에 비하여 월등히 증식을 빨리한다는 특성을 이용하고 있다. 증식이 빠르다는 것은 다시 말하면 유전 정보를 가지고 있는 DNA의 복제가 빠르다는 것을 의미한다. 만약 DNA의 복제를 방해한다면 증식이 아주 빠른 암세포에게는 치명적이지만 영원히 증식을 하지 않는 DNA의 복제가 거의 필요없는)신경세포나 증식이 암세포에 비해서 아주 느린 정상세포에는 거의 영향을 주지 못한다. 하지만 신체에서도 증식이 암세포와 비슷한 수준으로 일어나는 정상적인 세포가 있는데 그것은 머리카락을 만드는 모낭세포와 소화관의 점막을 이루는 세포와 혈액의 세포를 만드는 골수 세포이다. 그러므로 항암제를 사용할 경우 암세포와 마찬가지로 이들 세포도 함께 치명적인 영향을 입을 것은 당연하다(그래서 항암제 치료시엔 머리가 빠지고 소화불량이 잘 온다). 알칼화약물의 경우에는 DNA와 직접 결합을 하여 DNA의 복제를 억제함으로써 항암제의 역할을 수행한다. |
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| DTIC | Dimethyl Triazeno Imidazole Carboxamide ; Alkylating Agent |
|---|---|
| AAT | Aachen Aphasia Test; academic aptitude test; alanine aminotransferase; alkylating agent therapy; alp... |
| ALK, alk | alkaline; alkylating |
| OHA | Oral Hypoglycemic Agents |
| CTA | Canadian Tuberculosis Association; chemotactic activity; chromotropic acid; Committee on Thrombolyti... |
| AA | alkylating agent |
|---|---|
| CWA | Chemical warfare agents |
| DBA | Dentin bonding agents |
| NSAID | non steroidal anti-inflammatory agents |
| NSAIA | Non-steroidal anti-inflammatory agents |
cactus grandiflorus
| antineoplastic agent, alkylating | A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumour efficacy and the presence in their chemical structures of n-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumour cells are not completely understood. (12 Dec 1998) |
|---|---|
| alkylating agents | Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agent, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases. (12 Dec 1998) |
| antineoplastic and immunosuppressive agents | Collective grouping for substances used to arrest the proliferation of malignant cells and those that suppress the immune response. (12 Dec 1998) |
| alkylating agent | <oncology, pharmacology> A reagent that places an alkyl group, for example propyl in place of a nucleophilic group in a molecule. Alkylating reagents include a number of cytotoxic drugs some of which react fairly specifically with N7 of the purine ring and lead to depurination of DNA, for example the agent ethyl ethanesulphonic acid and thus to mutagenesis. The drugs interaction with DNAand prevents the division of the cells. Examples of drugs include: busulphan, chlorambucil, cyclophosphamide, melphalan. (29 Sep 1997) |
| antibiotics, antineoplastic | Chemical substances, produced by microorganisms, inhibiting or preventing the development of neoplasms. (12 Dec 1998) |
| antimetabolites, antineoplastic | Antimetabolites that are useful in cancer chemotherapy. (12 Dec 1998) |
| antineoplastic | Inhibiting or preventing the development of neoplasms, checking the maturation and proliferation of malignant cells. Origin: Gr. Plassein = to form (18 Nov 1997) |
| antineoplastic agent | Agents inhibiting or preventing the growth of neoplasms, checking the maturation and proliferation of malignant cells. (12 Dec 1998) |
| antineoplastic agent, combined | The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form. (12 Dec 1998) |
| antineoplastic agent, hormonal | Antineoplastic agent that are used to treat hormone-sensitive tumours. Hormone-sensitive tumours may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumour regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumours may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukaemias. (12 Dec 1998) |
| antineoplastic agent, phytogenic | Agents, obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (12 Dec 1998) |
| antineoplastic drug | A drug that stops or slows the maturation and spread of tumour cells (benign or malignant). (09 Oct 1997) |
| abortifacient agents | Chemical substances that interrupt pregnancy after implantation. (12 Dec 1998) |
| abortifacient agents, non-steroidal | Non-steroidal chemical compounds with abortifacient activity. (12 Dec 1998) |
| abortifacient agents, steroidal | Steroidal compounds with abortifacient activity. (12 Dec 1998) |
Synonyms : Alkylating Antineoplastic Agents, Alkylating Antineoplastic Drugs, Alkylating Antineoplastics, Alkylating Drugs, Antineoplastic, Antineoplastic Alkylating Agents, Antineoplastic Drugs, Alkylating, Antineoplastics, Alkylating, Antineoplastic Alkylating Drugs
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|