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AFL Atrial flutter
  = Af
AFL antifibrinolysin; artificial limb; atrial flutter
AFLNH angiofollicular lymph node hyperplasia
AFLP acute fatty liver of pregnancy
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Af Atrial flutter
  = AFL
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AFL Aflatoxicol
AFL Atrial flutter
AFLP Acute fatty liver of pregnancy
AFLP Amplified Fragment Length Polymorphism
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  • JrId: 335
    JournalTitle: The AFL-CIO American federationist. AFL-CIO
    MedAbbr: AFL CIO Am Fed
    ISSN: 0149-2489
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    NlmId: 9877748
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aflatoxicosis A disease caused by ingestion of aflatoxin.
(05 Mar 2000)
aflatoxin <chemical, microbiology, oncology> A fungal toxin which is a powerful liver carcinogen, found particularly in undeveloped and developing countries.
A group of closely related toxic metabolites that are designated mycotoxins. They are produced by aspergillus flavus and a. Parasiticus. Members of the group include aflatoxin b1, aflatoxin b2, aflatoxin g1, aflatoxin g2, aflatoxin m1, and aflatoxin m2.
Pharmacological action: carcinogens, mutagens, teratogens.
(27 Jun 1999)
aflatoxin b1 <chemical> A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals.
It is found as a contaminant in peanuts, cotton seed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin b1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin m1 and q1.
Pharmacological action: carcinogens, mutagens, teratogens.
Chemical name: Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-
(27 Jun 1999)
aflatoxin B1 aldehyde reductase <enzyme> Catalyses the conversion of the dialdehydic form of aflatoxin b1-dihydrodiol to the dialcohol form
Registry number: EC 1.1.1.-
Synonym: aflatoxin b1-aldehyde reductase, afb1-ar
(26 Jun 1999)
aflatoxin B1 hydroxylase <enzyme> Hydroxylases may be replaced by mixed function oxidases as appropriate
Registry number: EC 1.14.-
Synonym: aflatoxin b1 4-hydroxylase
(26 Jun 1999)
aflatoxin B1 reductase <enzyme> Reduces the cyclopentenone ring of aflatoxin b1 to aflatoxicol; requires NADPH as cofactor
Registry number: EC 1.1.1.-
(26 Jun 1999)
aflatoxin G2a reductase <enzyme> Has broad substrate specificity in cell-free extracts from aspergillus parasiticus; versicolorin a hemiacetal is reduced to versicolorin c; 17-hydroxy-16,17-dihydrosterigmatocystin is reduced to a 14,17-hydrated derivative; aflatoxin g2a is converted to a 13,16-hydrated derivative of afg2
Registry number: EC 1.1.1.-
(26 Jun 1999)
aflatoxin m1 <chemical> Highly toxic 4-hydroxylated metabolite of aflatoxin b1 found in the milk of cows fed toxic meal.
It has mutagenic, carcinogenic, and teratogenic activity. It is formed by the enzymatic hydroxylation of aflatoxin b1 by aflatoxin b1 4-hydroxylase, a cytochrome p-450-dependent enzyme.
Pharmacological action: carcinogens, mutagens, teratogens.
Chemical name: Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-
(27 Jun 1999)
AFLP <technique> Invented by KeyGene, a Dutch biotech company based in Wageningen, Holland. The technique is now merchandised under licence agreement by Perkin Elmer.
Selected markers are amplified in a PCR, which makes amplified fragment length polymorphism an easy and fast tool for strain identification in agriculture, botany, microbiology and animal breeding.
Acronym: AFLP
(05 Feb 1998)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 3 ÆäÀÌÁö: 1
  • Aflatoxin B1 - »õâ A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
    Synonyms : Aflatoxin B, Aflatoxin B1 Dihydrochloride, (6aR-cis)-Isomer, Aflatoxin B1, (6aR-cis)-Isomer, 14C-Labeled, Aflatoxin B1, (6aR-cis)-Isomer, 2H-Labeled, Aflatoxin B1, (6aR-cis)-Isomer, 3H-Labeled, Aflatoxin B1, cis(+, -)-Isomer, HSDB-3453, NSC-529592
  • Aflatoxin M1 - »õâ A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
    Synonyms : 4-Hydroxyaflatoxin B1, Aflatoxin M, Aflatoxin M1, cis(+-)-Isomer, 4 Hydroxyaflatoxin B1
  • Aflatoxins - »õâ Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.
    Synonyms : Aflatoxin
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AFl American Federation of Labor: a federation of North American labor unions that merged with the Congress of Industrial Organizations in 1955
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aflatoxin a potent carcinogen from the fungus Aspergillus; can be produced and stored for use as a bioweapon
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AFL a federation of North American labor unions that merged with the Congress of Industrial Organizations in 1955
AFL the largest federation of North American labor unions
AFL (especially of the face) reddened or suffused with or as if with blood from emotion or exertion
AFL lighted up by or as by fire or flame
AFL keenly excited (especially sexually) or indicating excitement
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AFL streaming or flapping or spreading wide as if in a current of air
AFL a nonsteroidal anti-inflammatory drug (trademarks Aleve and Anaprox and Aflaxen)
AFL shining unsteadily
AFL borne on the water
AFL covered with water
AFL aimlessly drifting
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