| 5-oxoproline | A keto derivative of proline that is formed nonenzymatically from glutamate, glutamine, and gamma-glutamylated peptides; it is also produced by the action of gamma-glutamylcyclotransferase; elevated levels of 5-oxoproline are often associated with problems of glutamine or glutathione metabolism. Synonym: 5-pyrrolidone-2-carboxylic acid, pyroglutamic acid, pyrrolidone-5-carboxylate. (05 Mar 2000) |
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| 5-oxoproline |
a ninhydrin-negative, acidic lactam of glutamic acid occurring at the N-terminus of several peptides and proteins. Called also pyroglutamic acid or pyroglutamate.
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