| 5-methyltetrahydrofolate-homocysteine s-methyltransferase | <enzyme> An enzyme that catalyses the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. Chemical name: 5-Methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase Registry number: EC 2.1.1.13 (12 Dec 1998) |
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Synonyms : Methionine Synthase, Vitamin B12-Dependent Methionine Synthase, Vitamin B12-Independent Methionine Synthase, Homocysteine Methyltransferase, Methyltetrahydrofolate, Methyltransferase, Methyltetrahydrofolate Homocysteine, Synthase, Methionine
| 5-methyltetrahydrofolate |
a substituted, reduced derivative of folic acid, occurring as a source of methyl groups for the regeneration of methionine; it is formed by reduction of 5,10-methylenetetrahydrofolate and is the principal form of folic acid during transport and storage in the body.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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| 5-methyltetrahydrofolate–homocysteine S |
[EC 2.1.1.13] an enzyme of the oxidoreductase class that catalyzes the remethylation of homocysteine to form methionine, using 5-methyltetrahydrofolate as a methyl donor and requiring methylcobalamin as a coenzyme; the reaction also regenerates tetrahydrofolate. Deficiency of enzyme activity can result from any of several defects, including deficiency of the apoenzyme, inability to convert cobalamin specifically to methylcobalamin or, more generally, to either of the cobalamin-containing coenzymes, deficiency of 5,10-methylenetetrahydrofolate reductase activity, familial megaloblastic anemia or other defect in absorption or transport of vitamin B12, or nutritional deficiency of vitamin B12 or folate; it results in homocystinuria, with developmental delay and neurologic abnormalities, and hypomethioninemia. Defects in cobalamin metabolism are characterized additionally by hematologic abnormalities and some also by methylmalonicacidemia (q.v.).
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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