Synonyms : 5, 10-Methylenetetrahydrofolate Reductase (FADH)
| 5,10-methylenetetrahydrofolate |
a doubly methylated, reduced derivative of folic acid occurring as an intermediate in the transfer of methyl groups to methionine, receiving them from formaldehyde, serine, and glycine.
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| 5,10-methylenetetrahydrofolate reductase (FADH2) |
[EC 1.7.99.5] an enzyme of the oxidoreductase class that catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahdyrofolate, using FADH2 and NADH as primary and secondary electron donors, respectively. The reaction is the means by which methyl groups are generated de novo for methylation reactions. Deficiency of the enzyme, an autosomal recessive trait, results in homocystinuria due to deficiency of 5-methyltetrahydrofolatehomocysteine S-methyltransferase; hypomethioninemia and neurologic abnormalities are present but megaloblastic anemia is absent.
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