| ICT | icteric, icterus; indirect Coombs test; inflammation of connective tissue; insulin coma therapy; int... |
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| IDM | idiopathic disease of myocardium; immune defense mechanism; indirect method; infant of diabetic moth... |
| IF | idiopathic fibroplasia; idiopathic flushing; immersion foot; immunofluorescence; indirect fluorescen... |
| IH | idiopathic hirsutism; idiopathic hypercalciuria; immediate hypersensitivity; incompletely healed; in... |
| IIF | immune interferon; indirect immunofluorescence |
| hybrid antibody | <immunology> Artificially produced antibody made by fusing hybridomas producing two different antibodies, the hybrid cells produce three different antibodies, only one of which is a heterophilic antibody. Can also be prepared chemically from two antibodies. (18 Nov 1997) |
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| hyperimmune antibody | An antibody which occurs in a hyperimmune individual and which targets the antigen that has brought on the hyperimmunity. (09 Oct 1997) |
| natural antibody | Antibody demonstrable in the serum or plasma of various persons or animals not known to have been stimulated by specific antigen, either artificially or as the result of naturally occurring contact. Synonym: natural antibody. (05 Mar 2000) |
| neutralizing antibody | A form of antibody that reacts with an infectious agent (usually a virus) and destroys or inhibits its infectivity and virulence; may be demonstrated by means of mixing serum with the suspension of infectious agent, and then injecting the mixture into animals or cell cultures that are susceptible to the agent in question. (05 Mar 2000) |
| nonprecipitable antibody | Antibody that, under conditions normally employed in precipitin tests, is refractory to precipitation by specific antibody, demonstrable when antigen is added serially in small amounts; nonprecipitating antibody will precipitate under special conditions such as addition of complement. Synonym: nonprecipitable antibody. (05 Mar 2000) |
| nonprecipitating antibody | Antibody that, under conditions normally employed in precipitin tests, is refractory to precipitation by specific antibody, demonstrable when antigen is added serially in small amounts; nonprecipitating antibody will precipitate under special conditions such as addition of complement. Synonym: nonprecipitable antibody. (05 Mar 2000) |
| normal antibody | Antibody demonstrable in the serum or plasma of various persons or animals not known to have been stimulated by specific antigen, either artificially or as the result of naturally occurring contact. Synonym: natural antibody. (05 Mar 2000) |
| syndrome, antiphospholipid antibody | An immune disorder characterised by the presence of abnormal antibodies in the blood associated with certain medical conditions including abnormal blood clotting, migraine headaches, premature miscarriage, and low blood platelet counts (thrombocytopenia). (12 Dec 1998) |
| double antibody immunoassay | A method of separating antibody-bound antigen (e.g., insulin) from free antigen by precipitating the former with antibody specific for immunoglobulin. Synonym: double antibody immunoassay, double antibody method. (05 Mar 2000) |
| double antibody method | A method of separating antibody-bound antigen (e.g., insulin) from free antigen by precipitating the former with antibody specific for immunoglobulin. Synonym: double antibody immunoassay, double antibody method. (05 Mar 2000) |
| double antibody precipitation | A method of separating antibody-bound antigen (e.g., insulin) from free antigen by precipitating the former with antibody specific for immunoglobulin. Synonym: double antibody immunoassay, double antibody method. (05 Mar 2000) |
| double antibody sandwich assay | For antigen; an application of the ELISA method in which material being tested for antigen is added to wells coated with known antibody; the presence of antigen fixed to the antibody coat can be determined either directly, by adding human antibody linked to the enzyme of the indicator system, or indirectly, by first adding unlabelled known antibody, the attachment of which to the antigen can be demonstrated by addition of immunoglobulin-specific antibody linked to the enzyme. (05 Mar 2000) |
| idiotype antibody | <immunology> An antibody directed against the antigen specific part of the sequence of an antibody or T-cell receptor and thus recognise the binding sites of other antibodies. In principle an anti-idiotype antibody should inhibit a specific immune response and they are important to the regulation of the immune system. (13 Nov 1997) |
| IgM antibody capture ELISA | Developed to impart significant improvement in assay specificity to indirect ELISA procedures for IgM isotype antibodies. Solid-phase support (usually microtitre plate wells) are coated with anti-human IgM antibodies capable of binding all IgM isotype antibodies present in the specimen. Reagent antigen is then added, followed by enzyme-labelled antigen-specific antibodies. If IgM antibodies specific for the antigen in question are present, the "sandwich" complex will result in enzymatic colour-change proportional to the concentration of IgM-specific antibody present. This technique appears to be the method of choice in many highly specific and more sensitive assays for IgM infectious disease antibodies. Acronym: MAC ELISA (05 Mar 2000) |
| immobilizing antibody | Antibody, evoked during syphilitic infections, possessing specific affinity for Treponema pallidum, and which in the presence of complement immobilises the organism. Synonym: immobilizing antibody, treponemal antibody. (05 Mar 2000) |