| collagen fibre | An individual fibre that varies in diameter from less than 1 um to about 12 um and is composed of fibrils; the fibre's, which are usually arranged in bundles, undergo some branching and are of indefinite length; chemically the fibre is a glycoprotein, collagen, which yields gelatin upon boiling; they make up the principal element of irregular connective tissue, tendons, aponeuroses, and most ligaments, and occur in the matrix of cartilage and osseous tissue. Synonym: white fibre. (05 Mar 2000) |
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| collagen fibrils | The fibril's that comprise a collagen fibre, ranging from 20 to 200 nm and averaging about 100 nm in diameter (substantially larger in tendons), with cross-striations averaging 64 nm. Synonym: collagen fibrils. (05 Mar 2000) |
| collagen injection | Correction of superficial soft tissue deformities, acne scars, or age-related skin changes by injection (implantation) of collagen; bovine collagen preparations are commonly used. Prior intradermal testing is necessary to exclude hypersensitivity. (05 Mar 2000) |
| collagen telopeptidase | <enzyme> Neutral metalloproteinase from porcine gingiva; removes the extra-helical extension peptides proximal to the lysyl residue at position 17 Registry number: EC 3.4.24.- Synonym: collagen depolymerase (26 Jun 1999) |
| collagen-vascular diseases | A group of generalised disease's affecting connective tissue and frequently characterised by fibrinoid necrosis or vasculitis; in some collagen disease's, auto-immunization, particularly antinuclear antibodies, has been shown and circulating immune complexes are found. The term is not entirely acceptable because there is no evidence that collagen is primarily involved; "collagen" was once synonymous with "connective tissue" rather than describing a specific fibrinous protein in that tissue. See: connective-tissue diseases. (05 Mar 2000) |
| collagenase | <enzyme> Proteolytic enzyme capable of breaking native collagen. Once the initial cleavage is made, less specific proteases will complete the degradation. Collagenases from mammalian cells are metallo enzymes and are collagen type specific. May be released in latent (proenzyme) form into tissues and require activation by other proteases before they will degrade fibrillar matrix. Bacterial collagenases are used in tissue disruption for cell harvesting. (18 Nov 1997) |
| collagenase A | <enzyme> An enzyme that catalyses the hydrolysis of collagen, preferentially at peptide bonds on the amino side of a glycylprolyl sequence. Synonym: clostridiopeptidase A, collagenase A, collagenase I. (05 Mar 2000) |
| collagenases | <enzyme> Enzymes that catalyze the degradation of collagen by acting on the peptide bonds. Registry number: EC 3.4.24.- (12 Dec 1998) |
| collagenation | 1. Replacement of tissues or fibrin by collagen. 2. Synthesis of collagen by fibroblasts. Synonym: collagenation. (05 Mar 2000) |
| collagenic | Producing or containing collagen. Synonym: collagenic. (05 Mar 2000) |
| collagenization | 1. Replacement of tissues or fibrin by collagen. 2. Synthesis of collagen by fibroblasts. Synonym: collagenation. (05 Mar 2000) |
| collagenolytic | Causing the lysis of collagen, gelatin, and other proteins containing proline. Origin: collagen + G. Lysis, dissolving (05 Mar 2000) |
| collagenosis | See: collagen diseases. (05 Mar 2000) |
| collagenous | Producing or containing collagen. Synonym: collagenic. (05 Mar 2000) |
| collagenous colitis | Colitis occurring mostly in middle-aged women and characterised by persistent watery diarrhoea and a deposit of a band of collagen beneath the basement membrane of colon surface epithelium. (05 Mar 2000) |