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opiate a. any of a class of compounds that bind with a number of closely related specific receptors (opioid receptors) in the central nervous system to block the perception of pain or affect the emotional response to pain; such compounds include opium and its derivatives, as well as a number of synthetic compounds, and are used for moderate to severe pain. Chronic administration or abuse may lead to dependence.
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opiate r. any of a number of types of receptors for opiates and opioids; at least seven different types are postulated at different locations in the body, grouped into three major classes (δ, κ, and μ) according to the specific substances they bind and to the specific physiological effect(s) (e.g., analgesia, respiratory depression, or a psychotomimetic effect) that binding causes or inhibits. See accompanying table.
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Opie p. necrotizing local anaphylaxis sometimes acts as a specific protective mechanism.
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opioid p. opioid (def. 2).
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opipramol hydrochloride a tricyclic antidepressant with mild tranquilizing properties; administered orally.
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