| succinate-CoA ligases | <enzyme> Enzymes that catalyze the first step leading to the oxidation of succinic acid by the reversible formation of succinyl-CoA from succinate and CoA with the concomitant cleavage of ATP to ADP (ec 6.2.1.5) or GTP to GDP (ec 6.2.1.4) and orthophosphate. Itaconate can act instead of succinate and itp instead of GTP.ec 6.2.1.-. Chemical name: Succinate:CoA ligase (GDP- or ADP-forming) Registry number: EC 6.2.1.- (12 Dec 1998) |
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| D-3-hydroxyacyl CoA dehydratase | <enzyme> From rat liver peroxisomes; catalyses the epimerization of d-3-hydroxyacyl CoA by the dehydration of 3-hydroxyacyl-CoA to 2-trans-enoyl-CoA followed by the hydration of the latter enzyme to l-3-hydroxyacyl-CoA by enoyl-CoA hydratase (EC 4.2.1.17); is not active on 2-cis-enoyl CoA; consider also EC 4.2.1.74 Registry number: EC 4.2.1.- Synonym: d-3-hydroxyacyl coenzyme a dehydratase, beta-hydroxyacyl-CoA dehydratase (26 Jun 1999) |
| delta(3,5),delta(2,4)-dienoyl-CoA isomerase | <enzyme> Catalyses the isomerization of 3,5-octadienoyl-CoA to 2,4-octadienoyl-CoA Registry number: EC 5.3.3.- Synonym: ddd-CoA-isomerase, delta(3,5),t(2,4)-dienoyl-CoA isomerase (26 Jun 1999) |
| deoxycholoyl-CoA synthetase | <enzyme> Catalyses the synthesis of deoxycholoyl-CoA from deoxycholic acid in rat liver Registry number: EC 6.2.1.- Synonym: deoxycholic acid CoA ligase, deoxycholate CoA ligase, deoxycholoyl-coenzyme a synthetase (26 Jun 1999) |
| dicarboxylic acid-CoA oxidase | <enzyme> Oxidises dicarboxylic acid CoA esters using molecular oxygen and producing hydrogen peroxide, ultimately producing a dicarboxylic acid with 2 fewer carbon atoms Registry number: EC 1.3.3.- Synonym: dicarboxylyl-CoA oxidase, dicarboxylic acid-coenzyme a oxidase (26 Jun 1999) |
| dicarboxylic acid-CoA synthetase | <enzyme> Converts dicarboxylic acids (c5-c16) into their mono-CoA esters in the presence of ATP Registry number: EC 6.2.1.- Synonym: dicarboxylyl-CoA ligase, dicarboxylic acid-coenzyme a synthetase (26 Jun 1999) |
| dodecanoyl-CoA synthetase | <enzyme> Fatty acid thiokinase (long-chain), a ligase forming acyl-CoA, AMP, and pyrophosphate from long-chain fatty acids, ATP, and coenzyme A. Activity is independent of phosphatidylcholine Registry number: EC 6.2.1.3 Synonym: acyl-activating enzyme, dodecanoyl-CoA synthetase, fatty acid thiokinase (long chain), acid-coenzyme a ligase, fatty acid-CoA ligase, acyl-CoA synthetase, acyl-CoA ligase, coash ligase, ciprofibroyl-CoA synthetase, pristanoyl-CoA synthetase, palmityl CoA synthetase, palmitoyl CoA synthetase, palmitoyl CoA ligase, fatty acyl-CoA synthetase, very long chain fatty acid acyl-CoA synthetase, vlcfa acyl-CoA synthetase, nafenopin-CoA ligase, palmitoyl-CoA synthase, faa2 gene product, faa2p protein, vlacs enzyme (26 Jun 1999) |
| isobutyryl-CoA mutase | <enzyme> Catalyses conversion of butyryl-CoA to isobutyryl-CoA Registry number: EC 5.4.99.- (26 Jun 1999) |
| isovaleryl-CoA | The condensation product of isovaleric acid and coenzyme A; an intermediate in the catabolism of l-leucine. Synonym: isovalerylcoenzyme A. Isovaleryl-CoA dehydrogenase, an enzyme that participates in the catabolism of l-leucine; it converts isovaleryl-CoA to 3-methylcrotonyl-CoA using FAD; a deficiency in this enzyme will result in isovaleric acidemia. (05 Mar 2000) |
| octanoyl-CoA synthetase | Fatty acid thiokinase (medium chain), a ligase forming acyl-CoA's from medium-chain fatty acids and CoA with the conversion of ATP to AMP and PPi. A key step in activation of fatty acids. Synonym: acyl-activating enzyme, butyryl-CoA synthetase, octanoyl-CoA synthetase. (05 Mar 2000) |
| oleyl-CoA | A product of the d9-desaturase enzyme system in the biosynthesis of monounsaturated fatty acids. Synonym: oleyl-coenzyme A. (05 Mar 2000) |
| oxalyl CoA decarboxylase | <enzyme> Catalyses the thiamine ppi-dependent decarboxylation of oxalyl-CoA to formate and carbon dioxide Registry number: EC 4.1.1.8 Synonym: oxalyl coenzyme a decarboxylase (26 Jun 1999) |
| tigloyl-CoA-13-hydroxymultiflorine-13-hydroxyupanine O-tigloyltransferase | <enzyme> Catalyses the tigloyl transfer from tigloyl-CoA to 13-hydroxymultiflorine and 13-hydroxyupanine Registry number: EC 2.3.1.- Synonym: hmt-hltase (26 Jun 1999) |
| tiglyl-CoA | CH3-CH==C(CH3)-COSCoA;an intermediate in the degradation of l-isoleucine. Synonym: tiglyl-coenzyme A. (05 Mar 2000) |
| enoyl-CoA hydratase | <enzyme> An enzyme that catalyses reversibly the hydration of unsaturated fatty acyl-CoA to yield beta-hydroxyacyl-CoA. It plays a role in the oxidation of fatty acids and in mitochondrial fatty acid synthesis, has broad specificity, and is most active with crotonyl-CoA. Chemical name: (3S)-3-Hydroxyacyl-CoA hydro-lyase Registry number: EC 4.2.1.17 (12 Dec 1998) |