| homoserine dehydrogenase | <enzyme> An enzyme that catalyses the reduction of aspartic beta-saemialdehyde to homoserine, which is the branch point in biosynthesis of methionine, lysine, threonine and leucine from aspartic acid. Chemical name: L-Homoserine:NAD(P)+ oxidoreductase Registry number: EC 1.1.1.3 (12 Dec 1998) |
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| pyridoxine 4-dehydrogenase | <enzyme> Chemical name: dehydrogenase, pyridoxol 4- Registry number: EC 1.1.1.65 Synonym: pyridoxine phosphate dehydrogenase, pyridoxal reductase (26 Jun 1999) |
| pyruvate dehydrogenase | <enzyme> A complex multienzyme system that catalyses the conversion of (pyruvate + CoA + NAD) to (acetyl CoA + CO2 + NAD). (18 Nov 1997) |
| pyruvate dehydrogenase complex | <enzyme> A complex multienzyme system that catalyses the conversion of (pyruvate + CoA + NAD) to (acetyl CoA + CO2 + NAD). (18 Nov 1997) |
| pyruvate dehydrogenase complex deficiency | An autosomal recessive pyruvate metabolism disorder resulting from deficient enzyme activity in one of several proteins of pyruvate dehydrogenase complex, resulting in deficiency of acetyl CoA. Deficiency in acetyl CoA product reduces the synthesis of acetylcholine, thereby causing neurological abnormalities. Clinical presentations include lactic acidosis, mental retardation, and ataxia. (12 Dec 1998) |
| pyruvate dehydrogenase complex inactivase | <enzyme> Pharmacological action: enzyme inhibitor Registry number: EC 3.4.- (26 Jun 1999) |
| pyruvate dehydrogenase (cytochrome) | An oxidoreductase catalyzing reaction between ferricytochrome b1 and pyruvate to yield acetate and CO2, and ferrocytochrome b1. (05 Mar 2000) |
| pyruvate dehydrogenase (lipoamide) | An oxidoreductase catalyzing conversion of pyruvate and (oxidised) lipoamide to CO2 and S6-acetyldihydrolipoamide in two successive reactions: the first between pyruvate and thiamin pyrophosphate to yield CO2 and alpha-hydroxyethylthiamin pyrophosphate (active pyruvate); the second between the last named and lipoamide to regain the thiamin pyrophosphate and yield S6-acetylhydrolipoamide. Compare: alpha-ketodecarboxylase. (05 Mar 2000) |
| pyruvate dehydrogenase (lipoamide)-phosphatase | <enzyme> (pyruvate dehydrogenase (lipoamide))-phosphate phosphohydrolase. A mitochondrial enzyme that catalyses the hydrolytic removal of a phosphate on a specific seryl hydroxyl group of pyruvate dehydrogenase, reactivating the enzyme complex. Registry number: EC 3.1.3.43 (12 Dec 1998) |
| hydrogen dehydrogenase | <enzyme> Hoxf, hoxh, hoxu, and hoxy from rhodococcus opacus encode the alpha-, beta-, gamma-, and delta-subunits, respectively Registry number: EC 1.12.1.2 Synonym: hydrogen-nad+ oxidoreductase, nad-reducing hydrogenase, hoxf gene product, hoxu gene product, hoxy gene product, hoxh gene product (26 Jun 1999) |
| shikimate dehydrogenase | An oxidoreductase reversibly reacting 3-dehydroshikimic acid with NADPH acid to produce shikimic acid and NADP+ in l-phenylalanine and l-tyrosine biosynthesis. (05 Mar 2000) |
| hydroxybutyrate dehydrogenase | <enzyme> Chemical name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase Registry number: EC 1.1.1.30 (12 Dec 1998) |
| hydroxyisovalerate dehydrogenase | <enzyme> Catalyses the reversible reaction of 2-ketoisovalerate to d-hydroxyisovalerate; consists of a single peptide, mw 53 kD; a highly specific dehydrogenase from fusarium sambucinum Registry number: EC 1.1.1.- Synonym: d-hydroxyisovalerate dehydrogenase, d-hiv dehydrogenase (26 Jun 1999) |
| short-chain acyl-CoA dehydrogenase | See: acyl-CoA dehydrogenase (NADPH+). (05 Mar 2000) |
| N-acyl-D-mannosamine dehydrogenase | <enzyme> Catalyses the conversion of n-acetyl-d-mannosamine and nad+ to n-acetyl-d-mannosaminic acid and NADH Registry number: EC 1.1.1.- Synonym: nadm-dehydrogenase, n-acylmannosamine dehydrogenase (26 Jun 1999) |