| melanocyte |
any of the dendritic clear cells of the epidermis that synthesize tyrosinase and, within their melanosomes, the pigment melanin; the melanosomes are then transferred from melanocytes to keratinocytes.
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| melanocyte s. |
pigmentary s.
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| melanocyte-stimulating h. |
a melanotropic peptide secreted by the pituitary glands of certain other animals but not humans; it is derived from pro-opiomelanocortin. Types are designated α, β, and γ1 to γ3; α-MSH and β-MSH are released by the pars intermedia of the adenohypophysis in fish and amphibians. The acylated forms cause dispersion of pigment granules of melanocytes, producing a rapid change in skin coloration, while the non-acylated forms are neurotransmitters. α-MSH is identical to the N-terminal 13 residues of corticotropin, and β-MSH to the C-terminal 18 residues of γ-lipotropin. Immunoreactive “β-MSH” in humans consists of β- and γ-lipotropin. Administration of α-MSH or elevation of corticotropin in humans causes a slight increase in melanization. Called also intermedin and melanotropin.
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| melanocytic |
pertaining to or composed of melanocytes.
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| melanocytic n. |
a usually pigmented nevus, acquired or hereditary, caused by a disorder of melanocytes.
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