| MAD | major affective disorder; mandibulo-acral dysplasia; maximum allowable dose; methylandrostenediol; m... |
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| MHD | maintenance hemodialysis; mean hemolytic dose; mental health department; minimum hemolytic dilution;... |
| MPD | main pancreatic duct; maximum permissible dose; mean population doubling; membrane potential differe... |
| MTD | maximum tolerated dose; mean total dose; metastatic trophoblastic disease; Midwife Teacher's Diploma... |
| PD | Doctor of Pharmacy; Dublin Pharmacopoeia; interpupillary distance; Paget disease; pancreatic duct; p... |
| minimal lethal dose | <pharmacology> The minimal dose of a toxic substance or infectious agent that is lethal, as assayed in various experimental animals (e.g., the least amount of diphtheria toxin that, on an average, kills a 250-g guinea pig within 96 hours after subcutaneous inoculation). When followed by a subscript (generally "MLD50"), denotes the minimal dose that is lethal to a certain percentage (e.g., 50%) of animals so assayed, LD05. See: lethal dose. (05 Mar 2000) |
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| minimal reacting dose | The minimal dose of a toxic substance causing a reaction, as manifested in the skin of a series of susceptible test animals; the assay is based on the development of a characteristic, minimal but definite, "standard," focal inflammation (congestion and oedema, induration, degenerative changes, and desquamation of epidermal cells). (05 Mar 2000) |
| cumulative dose | The total dose resulting from repeated exposures to radiation of the same part of the body or of the whole body. (05 Mar 2000) |
| curative dose | The quantity of any substance required to effect the cure of a disease or that will correct the manifestations of a deficiency of a particular factor in the diet, effective dose used with therapeutically applied compounds. Synonym: therapeutic dose. (05 Mar 2000) |
| preventive dose | The smallest amount of any substance that will prevent occurrence of symptoms of a disease or the consequences of a lack of a particular factor in the diet. (05 Mar 2000) |
| high dose tolerance | The induction of tolerance by exposure to high doses of antigen. (05 Mar 2000) |
| sensitizing dose | In experimental anaphylaxis, the antigenic inoculum that renders an animal susceptible (sensitive) to anaphylactic shock following a subsequent inoculum (shocking dose) of the same antigen (anaphylactogen). (05 Mar 2000) |
| shocking dose | In experimental anaphylaxis, the inoculum of antigen that causes anaphylactic shock in an animal sensitised by a previous inoculum (sensitizing dose) of the same antigen. (05 Mar 2000) |
| skin dose | The quantity of radiation delivered to the skin surface. (05 Mar 2000) |
| daily dose | The total amount of a remedy that is to be taken within 24 hours. (05 Mar 2000) |
| depth dose | The dose of radiation at a distance beneath the surface, including secondary radiation or scatter, in proportion to the dose at the surface. (05 Mar 2000) |
| divided dose | A definite fraction of a full dose; given repeatedly at short intervals so that the full dose is taken within a specified period, usually one day. Synonym: fractional dose. (05 Mar 2000) |
| dose | 1. <pharmacology> A quantity to be administered at one time, such as a specified amount of medication. 2. <radiobiology> A general term denoting the quantity of radiation or energy absorbed. For special purposes it must be appropriately qualified. If unqualified, it refers to absorbed dose. Unit of absorbed dose is the rad. The SI unit is the gray (1 Gy = 1 J kg-1 = 100 R). Origin: Gr. Dosis = a giving (16 Dec 1997) |
| dose-effect curve | This is a graph drawn to show the relationship between the dose of a drug or other chemical and the magnitude of the graded effect that it produces. (09 Oct 1997) |
| dose-escalation | A preliminary clinical trial in which the amount of the drug is either periodically increased or increased with each new trial arm that is added. Used to determine how a drug is tolerated in people. (09 Oct 1997) |